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Regulation Of Adipose Tissue Metabolism By Nfkb P65 In Transgenic Mice, Tianyi Tang
Regulation Of Adipose Tissue Metabolism By Nfkb P65 In Transgenic Mice, Tianyi Tang
LSU Master's Theses
Inflammation has been widely reported to regulate adipocyte functions in adipose tissue. Our early study suggests that NFkB signaling pathway is activated by inflammation and involved in inhibition of insulin sensitivity in adipocytes. NFkB was found to inhibit PPARg function through several possible mechanisms in 3T3-L1 adipocytes. To test this possibility in vivo, we increased the NFkB activity in adipocytes in transgenic mice by expression of NFkB p65 subunit under the aP2 gene promoter. The phenotype study shows that the food intake, physical activity and development are similar in the two groups. The reproductivity was not different in the two …