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Tcdd Represses 3'IghRr Activation Through An Ahr-Dependent Shift In The Nf-Κb/Rel Protein Complexes Binding To Κb Motifs Within The Hs1,2 And Hs4 Enhancers, Richard L. Salisbury Jr.
Tcdd Represses 3'IghRr Activation Through An Ahr-Dependent Shift In The Nf-Κb/Rel Protein Complexes Binding To Κb Motifs Within The Hs1,2 And Hs4 Enhancers, Richard L. Salisbury Jr.
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Transcriptional regulation of the murine immunoglobulin heavy chain gene involves several regulatory elements including the 3'Igh regulatory region (3'IghRR) composed of at least four enhancers (hs3A; hs1,2; hs3B; hs4). Enhancers hs1,2 and hs4 contain binding sites for several transcription factors including NF-κB/Rel proteins and the AhR. Interestingly, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) profoundly inhibits 3'IghRR and hs1,2 activation induced by the B-cell activator lipopolysaccharide (LPS), but enhances the activation of the hs4. Within the hs4, the AhR binding site overlaps an NF-κB/Rel binding site suggesting that both the AhR and the NF-κB together may modulate of the 3' …