Digital Commons Network^™

A Visually Realistic Simulator For Autonomous Evtol Aircraft, Seth M. Nielsen

Theses and Dissertations

Electrically powered vertical takeoff and landing (eVTOL) aircraft could provide a new mode of air transportation of people and cargo that is low-cost, on-demand, and able to reach more areas than is possible with current technology. They have the unique ability to takeoff and land in congested spaces yet efficiently travel long distances which makes them a promising technology for applications such as rapid medical assistance, automated package delivery, or human transportation. This type of aircraft has only recently become a possibility, owing to advancements in battery technology, computing power, and sensor technologies, and thus support for eVTOLs is lacking …

Design And Analysis Of Flexible Insulated Pavement For Cold Region Applications, Zhuang Zhuo

Theses and Dissertations

Pavements in cold regions suffer from additional deterioration due to the influences of extreme climate on frost-susceptible subgrade layers. To address this problem, one efficient strategy is to add a thermal insulating layer above the frost-susceptible layer. This study aims to evaluate the insulating effects of four materials: XPS boards, tire chips, foamed glass aggregates, and foamed concrete. Large-scale insulated pavement boxes (1.2m×1.2m×0.8m) were constructed to compare the thermal performance of different materials. The thermal performance of each box was evaluated and graded based on indicators related to the short-term temperature decrease and long-term temperature variation.

Experimental results show that …

Laser Forming Of Compliant Mechanisms And Flat-Foldable Furniture, Daniel Calvin Ames

Theses and Dissertations

Compliant mechanisms are useful for improving existing machines and creating new ones that were not previously possible. They also help us to think of new methods and technologies needed to both improve existing systems as well as manufacture systems that have not been done before. The purpose of this thesis is to show novel implementations of compliant mechanisms into folding systems, and to show new methods for fabricating such mechanisms with nontraditional materials and on difficult scales. Folding systems are shown in furniture applications with chairs, stools, and childcare furniture applications as results of research into how such structures could …

Droplet-Based Fuel Property Measurements, Wanjun Dang

LSU Doctoral Dissertations

Ongoing work to find renewable biofuels to function as drop-in replacements or blending components with gasoline has identified a large number of fuel candidates. Given the vast number of potential biomass-derived fuel molecules and limited sample sizes, screening tools are required to down-select candidate fuels having desired physical properties to ensure good engine performance. This work investigates approaches for rapid screening of candidate fuels using micro-liter sample sizes targeting four properties -- surface tension, viscosity, heat of vaporization (HOV), and vapor pressure. Measurement techniques for fuel properties are developed based on unit phenomena for liquid fuel droplets including droplet oscillation …

Truss Bridge Damage Localization And Severity Estimation Using Influence Lines, Hamoud Alshallaqi

Civil and Environmental Engineering Theses and Dissertations

The safety of bridges is one of the primary concerns of researchers, engineers, and bridge owners and managers, especially when bridges are approaching the end of their intended service lives. The estimation of bridge condition and remaining service life is critical to prioritize the allocation of available funding for repairs and rehabilitation. Various methods, including both dynamic and static approaches, have been developed to detect and localize bridge damage and estimate its severity. This research presents a methodology for detecting a single damaged member in a truss bridge and estimating the severity of the damage using static vertical deflection influence …

Enhanced Security Utilizing Side Channel Data Analysis, Michael Taylor

Computer Science and Engineering Theses and Dissertations

The physical state of a system is affected by the activities and processes in which it is tasked with carrying out. In the past there have been many instances where such physical changes have been exploited by bad actors in order to gain insight into the operational state and even the data being held on a system. This method of side channel exploitation is very often effective due to the relative difficulty of obfuscating activity on a physical level. However, in order to take advantage of side channel data streams one must have a detailed working knowledge of how a …

Soil Moisture Dependent Runoff In A Dryland Region: An Investigation Of The Role Of Antecedent Conditions, Monitoring, And Modeling Strategies, Gerhard Schoener

Civil Engineering ETDs

Approximately 30% of the Earth’s land surface is characterized as arid or semiarid, including much of the western United States. Accurate runoff predictions are important for informed watershed management, particularly in rapidly urbanizing areas. Infiltration excess overland flow is the dominant mechanism for runoff generation in many dryland basins, and event-based infiltration or loss models are commonly used to estimate runoff. However, predictions are associated with considerable uncertainty due to the role antecedent soil moisture, an initial condition that must be set by the modeler. The objectives of my research were to (1) evaluate the impact of antecedent soil moisture …

The Effect Of Ph On Organic Carbon Uptake And Biological Phosphorus Removal By Tetrasphaera Polyphosphate Accumulating Organisms, Derek Belka

Civil Engineering ETDs

Tetrasphaera polyphosphate accumulating organisms (PAOs) have been found in greater abundance and may remove more P in full-scale enhanced biological phosphorus removal (EBPR) water resource recovery facilities (WRRF) worldwide than the more extensively studied Accumulibacter PAO. Understanding the effect that environmental conditions, such as pH, have on Tetrasphaera metabolisms is critical to understanding EBPR WRRF process upsets, achieving consistent low effluent P concentrations, and formulating optimization strategies. The objective of this study was to determine pH effects over the range from 5.5 to 8.5 on anaerobic amino acid uptake, P release, and cation release in a Tetrasphaera-enriched culture from …

Developing Iot-Based Geophysical Micro-Observatories Utilizing Cloud Computing, Joshua Sylvester

Computer Science and Engineering Theses and Dissertations

Instrumentation for collecting geophysical data, specifically heat flow, in lake and marine environments has been in existence for over fifty years. Despite this, the costs associated with data collection and the technological limitations of existing instrumentation can be preventative when conducting geophysical studies. Furthermore, the success rate of such studies is limited by the lack of real time data transmission capabilities when instruments are deployed for extended periods of time. As a solution to this problem we have created cost-effective and lightweight IoT-driven instrumentation and combined it with cloud computing technology facilitating real time data transmission to the cloud. Furthermore, …

Numerical Study Of Laryngeal Control Of Phonation Using Realistic Finite Element Models Of A Canine Larynx, Biao Geng

Electronic Theses and Dissertations

While many may take it for granted, the human voice is an incredible feat. An average person can produce a great variety of voices and change voice characteristics agilely even without formal training. Last several decades of research has established that the production of voice is largely a mechanical process: i.e., the sustained vibration of the vocal folds driven by the glottal air flow. Since one only has a single pair of vocal folds, the versatility comes with the ability to change the mechanical status of the vocal folds, including vocal fold length and thickness, tension, and level of adduction, …

Investigation Of Column Packing & Flow Profiles In Packed Chromatographic Columns, Karamjit Singh

Electronic Thesis and Dissertation Repository

Liquid chromatography is an important downstream operation in the health care, biotechnology, biopharmaceutical, and bioprocessing industries. Its high resolving power is utilized to capture valuable materials such as therapeutic proteins, antibodies, peptides, and nucleic acids. Column chromatography relates to a separation and/or purification technique in which a stationary "bed" of a packing medium or resin is contained within a rigid tube. The column efficiency is measured in terms of Number of plates and Asymmetry. Column Efficiency loss can occur during packing, during storage and during transportation. The detailed study has been done for column sizes 2.5 cm and 5 cm …

Behaviour Of Transmission Line Conductors Under Tornadoes, Dingyu Yao

Electronic Thesis and Dissertation Repository

Transmission line (TL) structure failures caused by tornadoes have been observed in multiple countries around the globe. The objective of this study is to develop an accurate load case that can simulate the critical tornado forces transmitted from the TL conductors to the towers. In order to achieve the goal, three different tornado wind fields, which were previously developed using computational fluid dynamic simulations, are considered. The tornado wind field provides the most critical forces on the TL conductors is determined and considered to obtain the critical load cases. Using the critical wind field, parametric studies are conducted to identify …

Characterization Of Phase Behavior In Idp Solutions By Uv-Vis Spectrophotometry And Phase Volume Fraction Measurements In Capillaries, Qing Sun

Biomedical Engineering ETDs

Intrinsically disordered proteins (IDPs) play vital roles in cell signaling and regulation by changing conformation dynamically under various stimulus. Thus, it is crucial to understand their physical properties in vitro especially liquid-liquid phase separation (LLPS). Here, we first used UV-vis spectrophotometry to investigate two of IDPs' physical properties – transition temperature (Tt) and coacervate size. This deeper insight allows us to further understand the dynamics of phase growth. We then constructed a binodal curve in the phase diagram by measurement of volume ratios in phase separated IDP solution in glass capillaries.

Detecting Viral Particles In Vitro Using Photoacoustic Flow Cytometry, Anie-Pier Samson

Electronic Theses and Dissertations

The Covid-19 pandemic is a powerful example of just how damaging the rapid spread of an unknown virus can be. Viruses have the ability to spread rapidly amongst individuals if not treated and controlled. The first key step towards treatment is the timely and specific diagnosis of the virus causing the infection. An innovative method for the rapid detection of viral particles in solution consists of tagging the viral particles paired with using photoacoustic flow cytometry to irradiate the particles and get a signal. The high affinity of Streptavidin for Biotin can be used to bind Streptavidin-coated microspheres to biotinylated …

Real-Time Monitoring Of Cell Death Progress Using Capacitance Spectroscopy, Suyang Wu

Electronic Theses and Dissertations

Biologics, including the monoclonal antibody (mAb), has experienced rapid development in the last decade. However, the price of biologics is often prohibitively high because of the low process efficiency. Delaying the inevitable cell death improves the productivity of upstream bioprocessing, whose success relies on monitoring the cell death onset that indicates the timing for preventive actions.

This study proposes to develop a real-time monitoring model that quantifies the dying cell percentage in lab-scale bioreactors using capacitance spectroscopy. The capacitance spectroscopy contains cell death-related information due to various physical properties changes during the cell death process, e.g., cytoplasmic conductivity change. The …

The Development Of A Novel Blood-Brain Barrier, Organ-On-A-Chip System And The Identification Of Erythrocytes As A Key Contributor To Age-Associated Neurological Decline, Payam Amiri

KGI Theses and Dissertations

Advancements in modern medicine have greatly extended human life expectancy. However, with the onset of age-associated conditions such as Alzheimer’s disease, autoimmune disorders, and certain cancers, healthy aging is becoming an increasingly pressing issue. Blood exchanges between young and old partners demonstrate old blood can cause detrimental effect to the young animal, notably on the brain tissue. However, the complexity of blood makes it difficult to identify what role the individual factors play in the aggregate observed effect. This dissertation seeks to explore the potential effects of erythrocytes on the brain as we age. Erythrocyte morphology and rigidity changes as …

Systems And Methods For Scalable Retinal Screening Programs, Jeremy Richard Benson

Computer Science ETDs

This dissertation addresses gaps in artificial intelligence-based computer vision tasks in the medical image processing field. We demonstrate effective methods for standardizing and augmenting digital fundus photographs so that robust convolutional neural network-based systems can perform high-throughput disease classification and generalize to never-before-seen data from novel camera technologies, scaling with the changing hardware landscape, as well as keeping up with vast amount of incoming data from the ever-increasing population. We also tackle the problem of discovering relevant samples in an unlabeled cohort of image data, thus widening the bottleneck to all downstream supervised machine learning tasks.

Investigation Of An Optimized Occupancy-Driven Hvac Control Strategy And Development Of A Scalable House/Grid Simulation, Kaleb Pattawi

Mechanical Engineering Master's Theses

Energy consumption in buildings is projected to increase more than 50% by 2050. Renewable energy sources are expected to increase and will help alleviate some of the energy demand; however, the intermittent nature of renewables makes it tough to effectively use energy in buildings. Various pricing schemes, including time of use electricity pricing, are used to encourage users to shift loads. Buildings need to be able to proactively react to changing energy sources and electricity prices in order to reduce over-generation of electricity and save money. This work demonstrates an optimized Heating Ventilation and Air Conditioning (HVAC) control strategy that …

The Rotator Cuff Tendon-To-Bone Interface: Maturation, Aging, And 3d Bioprinting For Regeneration, Xiping Jiang

Theses & Dissertations

Rotator cuff tendon injuries often occur at the tendon-to-bone interface (i.e., enthesis) area with a high prevalence for the elderly population. In addition, regeneration of the gradient structure of the enthesis is still a significant clinical challenge. Our studies aim to identify the histological, molecular, and biomechanical alterations of the rotator cuff enthesis with maturation and aging, and develop a novel therapeutic method using three-dimensional (3D) bioprinting technique to regenerate a functional enthesis. Striking variations of the entheses were observed both histologically and biomechanically during the maturation process. The histological features did not show many differences at the insertion site …

Prediction Equations To Determine Induced Force On Reinforcing Elements Due To Laterally Loaded Piles Behind Mse Wall And Lateral Load Test On Dense Sand, Pedro David Garcia Montesinos

Theses and Dissertations

Researchers performed 35 full-scale lateral load tests on piles driven within the reinforcement zone of a mechanically stabilized earth wall (MSE wall). Data defining the induced tensile force on the reinforcements during lateral pile loading was used to develop multi-linear regression equations to predict the induced tensile force. Equations were developed by previous researchers that did not consider the diameter of the pile, the fixed head condition, relative compaction, or cyclic loading. The purpose of this research was to include this tensile force data and develop prediction equations that considered these variables. Additionally, a full-scale lateral load test was performed …

Development Of Polymeric Cxcr4 Targeting Carriers For Sirna Delivery To Treat Acute Kidney Injury, Weimin Tang

Theses & Dissertations

Acute kidney injury (AKI) is a major kidney disease that is characterized by a sudden loss of renal function which manifests by a decrease in urine output and an increase in serum creatinine. AKI is a global healthcare burden associated with high morbidity, mortality, and increasing cost. Currently there are no effective pharmacological treatments available. Apoptosis induced by p53 has been demonstrated as an important pathological mechanism for the development of AKI. Meanwhile, CXCR4/SDF-1 axis has been associated with the inflammation during AKI, and CXCR4 is overexpressed on injured tubules. This dissertation hypothesized that polycations with CXCR4 targeting ability could …

Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery

Electronic Thesis and Dissertation Repository

Previous studies have demonstrated that satisfaction and revision rates following total knee arthroplasty (TKA) are lower than those of comparable surgeries such as total hip replacements. A leading cause for these revisions is joint instability which may be due to improper ligament balancing or poorly aligned surgical implants. One of the methods used to investigate biomechanical forces and kinematics is computational modelling of the post-operative TKA knee.

A unique knee model was used to investigate the biomechanical and kinematic effects of ligament model complexity, as well as the effects of simulating ligament wrapping versus ignoring ligament wrapping. We then used …

Behaviour Of Transmission Lines Subjected To Tornadoes Through Aeroelastic Testing And Numerical Modeling, Nima Ezami

Electronic Thesis and Dissertation Repository

Tornadoes, as a form of high intensity wind (HIW) events, represent major threats to transmission line systems in many regions around the globe. Transmission line systems are among the most vulnerable structures to tornadoes due to their expansion over hundreds of kilometers and, therefore, increased exposure to such localized wind events. A comprehensive research project has been developed over the past two decades at Western University to study this problem. The research conducted in this thesis provides a significant development to the advancement of knowledge in this area through achieving three main objectives. The first objective is to assess and …

Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey

Electrical and Computer Engineering ETDs

The resolution limit of optical microscopy can be extended by using Imaging Interferometric Microscopy (IIM), which uses a low numerical aperture (NA) objective lens to achieve resolution equivalent to that of a high-NA objective lens with multiple sub-images. Along with the resolution enhancement challenge, IIM often suffers from poor image quality. In this dissertation, several image quality improvement methods are proposed and verified with simulation and experimental results. Next, techniques to extend the resolution limit of IIM to ≤ 100nm using a low-NA objective lens are demonstrated. An experimental technique of using a grating coupler on …

State-Of-The-Art Of Thermal Control Solutions To Establish A Modular, Multi-Orbit Capable Spacecraft Thermal Management System Design Methodology, Robert C. Consolo Jr

Doctoral Dissertations and Master's Theses

Today, the exploration and exploitation of space continues to become a more common occurrence. All types of spacecraft (S/C) utilize various types of thermal management solutions to mitigate the effects of thermal loading from the unforgiving vacuum of space. Without an appropriately designed thermal system, components on-board the S/C can experience failure or malfunction due to fluctuations in temperatures either beyond the designed operational parameters or unstable oscillating temperatures. The purpose of this study is to perform a comprehensive review of technologies available today that are being used for thermal management onboard S/C in addition to investigating the means to …

Identifying And Evaluating Common Subgenres In Asymmetric Virtual Reality Games, Miah Dawes

Theses and Dissertations

Recent years have seen a significant growth in what designers and players call asymmetric virtual reality (AVR) games. This dissertation creates a framework that defines the relevant characteristics of AVR as a genre and describes five common genres of AVR games, including David(s) and Goliath, Hide and Seek, Perspective Puzzle, Order Simulation, and Lifeline. The core features of each subgenre are expounded. These subgenres are then evaluated using design workshops to observe novice game designs use these subgenres in their game design process. An analysis of the workshops found that the AVR subgenre framework may benefit novice game designers in …

Advancing Cell-Free Protein Synthesis Systems For On-Demand Next-Generation Protein Therapeutics And Clinical Diagnostics, Emily Ann Long Zhao

Theses and Dissertations

Recombinant proteins have many medical and industrial applications, but their use is complicated by commercial production and stability constraints. These issues are particularly challenging for recombinant proteins used in pharmaceutical therapeutics and clinical diagnostics. Expensive production and distribution limit the accessibility of therapeutics and diagnostics especially in the developing world. Additionally, clinical use of recombinant proteins face further challenges within biological systems including biological degradation and immunogenicity. To increase the accessibility of recombinant proteins, the cost and inefficiencies of protein manufacturing and distribution need to be significantly reduced. A powerful tool to aid in this endeavor is cell-free protein synthesis …

Noise And Time Pressure Effects On Situation Awareness And Aviation Maintenance Tasks, Syaza R. M. Haris

Doctoral Dissertations and Master's Theses

Aircraft maintenance technicians (AMTs) working in a line maintenance work setting are very susceptible to the deafening occupational noise from the airport vicinity or the maintenance machinery itself. Compared to a base maintenance working period, a line maintenance job requires AMTs to complete a task within a short time frame. The current study's objective is to determine if different noise levels and time pressure influence AMTs' performance and situation awareness (SA). Sixteen Embry-Riddle Aeronautical University students majoring in Aviation Maintenance Science participated in a within-subject experimental design. Each participant's performance, SA level, and perceived workload were measured during maintenance tasks …

Numerical Simulation Of A Cryogenic Spray, Neel Kishorkumar Shah

Doctoral Dissertations and Master's Theses

Cryogenic sprays have many applications in modern engineering. Cooling of electronic equipment subject to high heat flows, surgical ablation of gastrointestinal mucosae or orbital maneuvering are a few examples of their versatility. However, the atomization of a cryogenic liquid is a complex process. During such an event, aerodynamic effects associated with secondary atomization are further affected by thermodynamic flashing. A better understanding of the characteristics of cryogenic sprays is then necessary to allow for improved design and optimization in applications. The overarching objective of this study is to document such characteristics. The numerical simulation was performed over cryogenic nitrogen spray …

In-Situ Monitoring Of Additive Manufacturing Using Digital Image Correlation, Martina Jani

Doctoral Dissertations and Master's Theses

Advances in additive manufacturing over the past decade have led to applications in multiple fields. In particular, additive manufacturing answers the need for high flexibility in designing complex structures, however, the rapid thermal fluctuations during processing lead to numerous defects and processing-induced residual stresses. In this research, an in-situ approach using Digital Image Correlation (DIC) is developed to monitor the deformation during the processing, and thereby analyze the formation of defects and residual stresses. DIC is a visual technique that compares the changes in speckle pattern in consecutive images of a specimen to determine the displacements and strains. This research …