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Articles 1 - 8 of 8
Full-Text Articles in Entire DC Network
17th Biennial Cheese Industry Conference, Various Authors
17th Biennial Cheese Industry Conference, Various Authors
Cheese Industry Conference
No abstract provided.
2005 Annual Report, Various Authors
Enhanced Antiscrapie Effect Using Combination Drug Treatment, D. A. Kocisko, B. Caughey, John D. Morrey, R. E. Race
Enhanced Antiscrapie Effect Using Combination Drug Treatment, D. A. Kocisko, B. Caughey, John D. Morrey, R. E. Race
John D. Morrey
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
A Porphyrin Increases Survival Time Of Mice After Intracerebral Prion Infection, D. A. Kocisko, W. S. Caughey, R. E. Race, G. Roper, B. Caughey, John D. Morrey
A Porphyrin Increases Survival Time Of Mice After Intracerebral Prion Infection, D. A. Kocisko, W. S. Caughey, R. E. Race, G. Roper, B. Caughey, John D. Morrey
John D. Morrey
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
Evaluation Of Immunomodulators, Interferons And Known In Vitro Sars-Cov Inhibitors For Inhibition Of Sars-Cov Replication In Balb/C Mice, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, P. K-S. Chan, R. W. Sidwell
Evaluation Of Immunomodulators, Interferons And Known In Vitro Sars-Cov Inhibitors For Inhibition Of Sars-Cov Replication In Balb/C Mice, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, P. K-S. Chan, R. W. Sidwell
Animal, Dairy, and Veterinary Science Faculty Publications
Compounds approved for therapeutic use and in vitro inhibitors of severe acute respiratory syndrome coronavirus (SARS-CoV) were evaluated for inhibition in the mouse SARS-CoV replication model. A hybrid interferon, interferon alpha (IFN-alpha) B/D, and a mismatched double-stranded (ds) RNA interferon (IFN) inducer, Ampligen® (poly I:poly C124), were the only compounds that potently inhibited virus titres in the lungs of infected mice as assessed by CPE titration assays. When mice were dosed intraperitoneally (i.p.) with IFN-alpha B/D once daily for 3 days beginning 4 h after virus exposure, SARS-CoV replication in the lungs of infected mice was reduced by 1 log10 …
Comparative Toxicosis Of Sodium Selenite And Selenomethionine In Lambs, A. K. Tiwary, B. L. Stegelmeier, K. E. Panter, L. F. James, Jeffery O. Hall
Comparative Toxicosis Of Sodium Selenite And Selenomethionine In Lambs, A. K. Tiwary, B. L. Stegelmeier, K. E. Panter, L. F. James, Jeffery O. Hall
Animal, Dairy, and Veterinary Science Faculty Publications
Excess consumption of selenium (Se) accumulator plants can result in selenium intoxication. The objective of the study reported here was to compare the acute toxicosis caused by organic selenium (selenomethionine) found in plants with that caused by the supplemental, inorganic form of selenium (sodium selenite). Lambs were orally administered a single dose of selenium as either sodium selenite or selenomethionine and were monitored for 7 days, after which they were euthanized and necropsied. Twelve randomly assigned treatment groups consisted of animals given 0, 1, 2, 3, or 4 mg of Se/kg of body weight as sodium selenite, or 0, 1, …
Detection Of Early Stages Of Myxobolus Cerebralis In Fin Clips From Rainbow Trout (Onchorynchus Mykiss), Ramona T. Skirpstunas, J. Hergert, Thomas J. Baldwin
Detection Of Early Stages Of Myxobolus Cerebralis In Fin Clips From Rainbow Trout (Onchorynchus Mykiss), Ramona T. Skirpstunas, J. Hergert, Thomas J. Baldwin
Animal, Dairy, and Veterinary Science Faculty Publications
A nested polymerase chain reaction (PCR) assay was used to detect early stages of Myxobolus cerebralis in caudal and adipose fin samples from rainbow trout (RT). To determine sensitivity, groups of 10 RT were exposed to 2,000 M. cerebralis triactinomyxons/fish for 1 hour at 15 degrees C and subsequently moved to clean recirculating water. Fish were held for 2 and 6 hours and 1, 2, 3, 5, 7, 10, 30, and 60 days before sampling by nonlethal fin biopsy. Nested PCR performed on fin clips showed that M. cerebralis DNA was detected in caudal fin tissue in 100% of fish …
Humanized Monoclonal Antibody Against West Nile Virus Envelope Protein Administered After Neuronal Infection Protects Against Lethal Encephalitis In Hamsters, John D. Morrey, V. Siddharthan, Aaron L. Olsen, G. Y. Roper, H. Wang, Thomas J. Baldwin, S. Koenig, S. Johnson, J. L. Nordstrom, M. S. Diamond
Humanized Monoclonal Antibody Against West Nile Virus Envelope Protein Administered After Neuronal Infection Protects Against Lethal Encephalitis In Hamsters, John D. Morrey, V. Siddharthan, Aaron L. Olsen, G. Y. Roper, H. Wang, Thomas J. Baldwin, S. Koenig, S. Johnson, J. L. Nordstrom, M. S. Diamond
Animal, Dairy, and Veterinary Science Faculty Publications
Humans infected with West Nile virus (WNV) may clinically present with symptoms that are suggestive of neurological infection. Nearly all treatments of WNV disease have been effective in animal models only if administered before or soon after viral challenge. Here, we evaluated whether a potent neutralizing anti-WNV humanized monoclonal antibody (MAb), hE16, could improve the course of disease in a hamster model when administered after the virus had infected neurons in the brain. Five days after viral injection, WNV was detected in the brains of hamsters by cytopathic assay, quantitative reverse-transcription polymerase chain reaction, and immunohistochemical staining of WNV envelope …