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Altered Antibiotic Tolerance In Anaerobic Digesters Acclimated To Triclosan Or Triclocarban, Daniel Elliott Carey, Patrick J. Mcnamara
Altered Antibiotic Tolerance In Anaerobic Digesters Acclimated To Triclosan Or Triclocarban, Daniel Elliott Carey, Patrick J. Mcnamara
Civil and Environmental Engineering Faculty Research and Publications
Bench-scale anaerobic digesters were amended to elevated steady-state concentrations of triclosan (850 mg/kg) and triclocarban (150 mg/kg) using a synthetic feed. After more than 9 solids retention time (SRT) values of acclimatization, biomass from each digester (and a control digester that received no antimicrobials) was used to assess the toxicity of three antibiotics. Methane production rate was measured as a surrogate for activity in microcosms that received doses of antibiotics ranging from no-antibiotic to inhibitory concentrations. Biomass amended with triclocarban was more sensitive to tetracycline compared to the control indicating synergistic inhibitory effects between this antibiotic and triclocarban. In contrast, …