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Investigating The Biochemical Activity Of Some Flavonoids, Coumarins And Modified Gold-Nanoparticles As Anti-Breast-Cancer Agents, Amr Ezzat Mohamed Mahmoud
Investigating The Biochemical Activity Of Some Flavonoids, Coumarins And Modified Gold-Nanoparticles As Anti-Breast-Cancer Agents, Amr Ezzat Mohamed Mahmoud
Dissertations
Polyphenols compounds are abundant natural products found in many plants as secondary metabolites. These compounds display many interesting pharmacological activities, which have motivated chemists over the years to explore them, and their synthetic derivatives, as potential drugs, especially anticancer drugs. Breast cancer is the most common cancer in women globally, and in the United States of America the estimated worldwide new breast cancer cases and the number of deaths are 1.38 million and 458 thousand, respectively. Currently in the USA there are 2.6 million women who have been treated for breast cancer, and the estimated number of deaths are 39,520 …
Optical And Electrochemical Sensors For The Detection Of Metal Ions And Nerve Gas Mimics Via Fluorescein And Coumarin Derivatives, Fasil Adefris Abebe
Optical And Electrochemical Sensors For The Detection Of Metal Ions And Nerve Gas Mimics Via Fluorescein And Coumarin Derivatives, Fasil Adefris Abebe
Dissertations
Trace element detection of metals, for example, iron, Copper and zinc, are important in biological systems and in the environment. Many of us are aware that our cells contain metal ions that are “tied” up in proteins. However, chelatable or “free” trace elements can also be found in small quantities, and can have a negative impact on our bodies. Despite the increasing surge in developing sensors for metals and nerve gas agents, efficient detection still remains a challenge. Among the various sensors developed so far, fluorescence sensors play an important role due to their simplicity. I design fluorescein-based chemosensors for …
Optical And Electrochemical Properties Of Monolayer Protected Gold Clusters Modified With Fluorophores, Mary Sajini Devadas
Optical And Electrochemical Properties Of Monolayer Protected Gold Clusters Modified With Fluorophores, Mary Sajini Devadas
Dissertations
My research focused on the synthesis, characterization and the investigation of the optical and electrochemical properties of monolayer-protected quantum-sized gold clusters. Significant research attention was focused on the solution phase optical and electrochemical properties of these clusters. Highly monodisperse Au clusters with different types of ligands were successfully synthesized with sizes varying from 1 nm to 13 nm. These preformed gold clusters were modified with fluorophores and pseudo-rotaxanes for developing better nonlinear optical materials for sensing and biological imaging purposes. We have tried to focus on the interaction of the outer ligand shell, made up of –S-Au-S-Au-S- bonds, with the …