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Tetracycline-7-Boronic Acid, William Denham Rhoads
Tetracycline-7-Boronic Acid, William Denham Rhoads
University of the Pacific Theses and Dissertations
The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue.