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3-Amino-2,5-Dihydroxy-5-Sulfo-Benzoic Acid, Hideo Tomomatsu

University of the Pacific Theses and Dissertations

It seems possible that efforts to discover essential chemical differences which might exist between normal and malignant cells will eventually reveal the secret of cancer and thereby lead to new approaches to safer and more selective chemotherapy.

One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see …

Tetracycline-7-Boronic Acid, William Denham Rhoads

University of the Pacific Theses and Dissertations

The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that the tetracyclines are not retained by normal tissue should remove the danger of destruction of this tissue.

Preparation And Ultra-Violet Absorption Studies Of Leucocyanides Of The Triarylmethane Dyes, Arthur Katzakian Jr.

University of the Pacific Theses and Dissertations

No abstract provided.