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The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
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The potential value of the Y chromosome for forensic applications has been recognized for some time with the current work dedicated to Short Tandem Repeat analysis and Single Nucleotide Polymorphism (SNP) discovery. This study examined the ability of two different SNP analysis methods to determine if they could be utilized in forensic applications and ultimately be developed into an established system for Y chromosome SNP analysis. This study examined two principle SNP analysis systems: single base extension and Pyrosequencing. Pyrosequencing was determined to be superior to single base extension, due to the wealth of information provided with sequencing and the …