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Stability And Recovery Of Rna In Biological Stains, Mindy Eileen Setzer
Stability And Recovery Of Rna In Biological Stains, Mindy Eileen Setzer
Electronic Theses and Dissertations
In theory, RNA expression patterns, including the presence and relative abundance of particular RNA species, provide cell and tissue specific information that could be of use to forensic scientists. An mRNA based approach could allow the facile identification of the tissue components present in a body fluid stain and conceivably could supplant the battery of serological and biochemical tests currently employed in the forensic serology laboratory. Some of the potential advantages include greater test specificity, and the ability to perform simultaneous analysis using a common assay format for the presence of all body fluids of forensic interest. In this report, …
Method For Determination Of Singlet Oxygen Quantum Yields For New Fluorene-Based Photosensitizers In Aqueous Media For The Advancement Of Photodynamic Therapy, Wade William Grabow
Method For Determination Of Singlet Oxygen Quantum Yields For New Fluorene-Based Photosensitizers In Aqueous Media For The Advancement Of Photodynamic Therapy, Wade William Grabow
Electronic Theses and Dissertations
Photodynamic therapy (PDT) has been investigated over the past three decades and is currently an approved therapeutic modality for skin cancer, the treatment of superficial bladder, early lung and advanced esophageal cancers, and age-related macular degeneration in a number of countries. In PDT, the absorption of light by a chromophore generates cytotoxic species such as reactive singlet oxygen, leading to irreversible destruction of the treated tissue. The measurement of the singlet oxygen quantum yield is an important determinant used to evaluate the efficiency of new photodynamic therapy agents developed in the laboratory, to screen potential photosensitizers in aqueous media.The singlet …
Mitochondrial Dna Analysis By Pyrosequencing, Patsy-Ann Susan Hastings
Mitochondrial Dna Analysis By Pyrosequencing, Patsy-Ann Susan Hastings
Electronic Theses and Dissertations
Mitochondrial DNA (deoxyribo nucleic acid) is typically used in forensic casework when small quantities of high molecular weight quality DNA is not expected to be present thus negating the chances of obtaining usable nuclear DNA. Typical samples that utilized mitochondrial DNA analysis are: hair, bones, teeth, ancient remains (samples or remains that are at least 100 years old) or very old samples (samples that are less than 100 but greater than 10 years old). The current method used to evaluate mitochondrial DNA is Sanger sequencing. Although robust, it is also time consuming and labor intensive, on the other hand pyrosequencing …
Part I: Evaluation Of Russian Synthetic Compounds As A Potential Source Of New Drug Leads Agains Breast And Colon Cancer Part Ii: Isolation Of Beta-Amyrin Formate From Eucalyptus Viminalis Labill And Investigation Of Its Colon Cancer Activity, Mihaela Cohanoschi
Electronic Theses and Dissertations
Although modern medicine made great steps toward curing most diseases considered deadliest, yet cancer remains one of the major public health problems. The first part of this thesis investigates a new source of selective compounds that are potential candidates against cancer. Fifteen Russian compounds were tested in order to establish their efficiency against two types of cancer: human breast SK-Br-3 and colorectal carcinoma HT-29. The bioassay results show that seven of the new synthetic Russian compounds can be considered new drug leads, based upon their low toxicity and efficacy in slowing the growth of human breast cancer and colon cancer …
Synthesis And Polymerization Of Bifunctional Five-Membered Cyclic Dithiocarbonates And Their Use As Stabilizers For Magnetic Nan, Mohammed Daoudi
Synthesis And Polymerization Of Bifunctional Five-Membered Cyclic Dithiocarbonates And Their Use As Stabilizers For Magnetic Nan, Mohammed Daoudi
Electronic Theses and Dissertations
Novel bifunctional five-membered cyclic dithiocarbonates (1,3-oxathiolane-2-thione)s were synthesized by the reactions of the corresponding bifunctional oxiranes (epoxides) with carbon disulfide at room temperature with lithium bromide as catalyst. Full characterization of these monomers was performed including elemental analysis, proton and carbon nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectroscopy, and Fourier transmission infrared (FTIR) spectroscopy. The polyaddition polymerization of 1,3-oxathiolane-2-thione with 1,4-diaminobutane at room temperature resulted in a poly(thiourethane) material. The latter undergoes crosslinking due probably to the autooxidation of the product and formation of disulfide linkages. The five-membered cyclic dithiocarbonate, 5-decyl-1,3-oxathiolane-2-thione, was used a model to demonstrate the usefulness …
Synthesis Of A Novel Family Of Amide Derivatives Of Podocarpic Acid, Dao Nguyen
Synthesis Of A Novel Family Of Amide Derivatives Of Podocarpic Acid, Dao Nguyen
Electronic Theses and Dissertations
As a class, amides are of great interest in biological studies and pharmaceutical application. In this work, podocarpic acid, a natural tricyclic diterpene, derived from Podocarpus species, has been employed to form a novel family of amide derivatives which will later be studied for their potential as new drug leads. Novel amide derivatives of podocarpic acid were synthesized from podocarpic acid in three steps. The first step involved methylation with dimethylsulfate to form methyl-O-methylpodocarpate. This step was followed by iodination with iodine to give iodomethyl-O-methylpodocarpate. Finally amidation with various aliphatic amides using a copper catalyst yielded four amide derivatives of …
The Design And Development Of A Comprehensive 49 Locus Y-Str Database For Major U.S. Populations, Paulina Niki Berdos
The Design And Development Of A Comprehensive 49 Locus Y-Str Database For Major U.S. Populations, Paulina Niki Berdos
Electronic Theses and Dissertations
The establishment of a U.S. National Y-STR reference database from a variety of geographically and ethically diverse populations is essential to facilitate the generation of reliable estimates of Y-STR haplotype frequencies. Such multi-locus haplotype frequencies are required to provide a statistical estimate of the significance of a match. Y-STR loci, unlike traditional STR markers, are not independent of one another and are co-inherited as extended haplotypes of linked markers. The estimation of the frequency of occurrence of a particular haplotype therefore necessitates the use of a counting method, which means that the significance of many matches is dependent upon the …
Block Copolymer Stabilized Self-Assembled Magnetic Nanoparticles, Li Zhang
Block Copolymer Stabilized Self-Assembled Magnetic Nanoparticles, Li Zhang
Electronic Theses and Dissertations
Magnetic materials are currently being developed in the areas of pharmacology and medicinal chemistry for use in applications such as drug delivery and magnetic resonance imaging. Magnetic fluids are being used in audio equipment and hard disk drives. Their suspension in a particular fluid is promoted by the adsorption or reaction of steric or electrostatic stabilizers, which are appropriate for the particular medium. Critical to the success of these magnetic fluids is the development of the steric stabilizers, which must prevent the coagulation of the metal particles. Polymeric materials are one of the most suitable nonmagnetic media to disperse the …
New Organic/Inorganic Hybrid Sol-Gel Nanocomposite Materials For Raman Gain In Fiber Optics, Stephen James Andrasik
New Organic/Inorganic Hybrid Sol-Gel Nanocomposite Materials For Raman Gain In Fiber Optics, Stephen James Andrasik
Electronic Theses and Dissertations
The recent increased availability of additional wavelengths in the telecommunications window of about 1300-1600 nm has generated an interest in new optical materials and devices that can operate outside the normally used regions of 840 nm, 1310 nm, and 1550 nm. Specifically, methods to amplify fiber optical data transmission in the regions where there is limited or no existing methods to achieve amplification is of interest in the chemistry and photonic communities. Raman gain is one method that has been proposed to passively amplify optical data transmission through a distributed process. Amplification is obtained through a nonlinear light scattering process …
The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
Electronic Theses and Dissertations
The potential value of the Y chromosome for forensic applications has been recognized for some time with the current work dedicated to Short Tandem Repeat analysis and Single Nucleotide Polymorphism (SNP) discovery. This study examined the ability of two different SNP analysis methods to determine if they could be utilized in forensic applications and ultimately be developed into an established system for Y chromosome SNP analysis. This study examined two principle SNP analysis systems: single base extension and Pyrosequencing. Pyrosequencing was determined to be superior to single base extension, due to the wealth of information provided with sequencing and the …