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Antibacterial Testing On Silver/Zinc Oxide Nanoparticles/Organoclay Reinforced Chitosan Biocomposites, Lisna Junaeni Muiz, Ariadne Lakshmidevi Juwono, Zulkarnaen Paputungan, Yuni Krisyuningsih Krisnandi

Makara Journal of Science

Herein, bionanocomposites of chitosan (CS)/silver nanoparticle/organoclay/zinc oxide nanoparticle (CS/Ag/OC/ZnO) were prepared for antibacterial food packaging. This study examines the time variation in the AgNP synthesis method by comparing local (74˗85% deacetylated) and commercial chitosan (75%˗85% deacetylated) as a reducing and capping agent and seeks to reconstruct the optimum ratio formulations of AgNPs and ZnONPs in bionanocomposites for food packaging. The results reveal that the synthesis of AgNPs was successfully carried out using a local chitosan solution as a reducing and capping agent. The CS/Ag/OC/ZnO films exhibit structural, mechanical, and optical properties suitable for food packaging and antibacterial activity on Staphylococcus …

Carbon Quantum Dots And Chitosan-Based Heterogeneous Silver Catalyst For Reduction Of Nitroaromatic Compounds, Farah Sami̇r Sali̇m, İdri̇s Sargin, Gülşi̇n Arslan

Turkish Journal of Chemistry

Chitosan plays a crucial role in catalysis, environmental remediation, and sustainable chemistry as a renewable and cationic polysaccharide. Chitosan-based metal catalysts are used in a broad range of chemical transformations. In the study, carbon quantum dots (CQDs) were derived from Momordica charantia fruits by microwave irradiation following a green chemistry approach. Three catalysts were designed: Ag(0)-chitosan, Ag(0)-chitosan-M. charantia fruit powder, and Ag(0)-chitosan-CQDs. The catalyst supports were prepared by stabilizing CQDs or M. charantia powder within the polymeric matrix of chitosan beads. Metallic silver particles were anchored onto glutaraldehyde cross-linked chitosan beads from the aqueous solution of silver nitrate. The …

Co-Microencapsulation Of Ruellia Tuberosa L. And Cosmos Caudatus K. Extracts For Pharmaceutical Applications, Choirin Annisa, Sasangka Prasetyawan, Anna Safitri

Makara Journal of Science

This study aims to co-microencapsulate the Ruellia tuberosa L. and Cosmos caudatus K. extracts, with chitosan–sodium tripolyphosphate (Na-TPP) as coating material. α-Amylase inhibition and antioxidant assays were conducted to determine the potential of microcapsules used as antidiabetic agents. The microcapsules were manufactured under the influences of pH, Na-TPP concentration, and stirring time. The optimum microencapsulation conditions were selected based on the highest encapsulation efficiency. The optimum microencapsulation conditions were a pH of 4, Na-TPP concentration of 0.15% (w/v), and stirring time of 60 min. The microcapsules exhibited an IC₅₀ (inhibitory concentration) value of 223.64 ± 0.81 µg/mL and an …

Synthesis Of Phenyl Carbamoylated Guanidine Functionalized Chitosan, Eduardo Hernandez Requejo

FIU Electronic Theses and Dissertations

The lack of solubility of the chitosan in organic solvents hinders its potential for chemical modifications. For this reason, it was hypothesized that the insertion of the phenyl carbamoylated guanidine moiety could lead to increased solubility in DMSO and new potential modifications and uses.

This research involved the synthesis of S-methyl phenyl carbamoylated guanidine (SMPCG) starting from the commercially available S-methyl isothiourea. This was followed by the reaction of the SMPCG with chitosan to yield phenyl carbamoylated guanidine functionalized chitosan (PCGCs) with a degree of substitution of 14%.

The chitosan derivative is fully soluble in DMSO and partially in DMF. …

Investigation Of Boron Nanosized Particles Prepared With Various Surfactants And Chitosan In Terms Of Physical Stability And Cell Viability, Emrah Özakar, Mehmet Semi̇h Bi̇ngöl, Ruki̇ye Sevi̇nç Özakar

Turkish Journal of Chemistry

Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome the deficiencies of drugs with poor water solubility or insolubility and are considered to be one of the most successful approaches to formulate compounds in recent years. Boron nitride (BN) is insoluble in water and chemically more stable than carbon, it offers better biological superiority although the application of carbon structures in the biomedical field has increased in recent years. Chitosan is a polymer with excellent processability and biocompatibility thanks to its high dielectric constant. In addition, chitosan has a high affinity for metal ions. This …

Synthesis And Characterization Of Chitosan Derivatives Intended For Gene Delivery Applications, Alex M. Mcmullen

MSU Graduate Theses

Chitosan has been studied as a non-viral vector capable of efficient gene delivery due to its favorable properties such as biodegradability, biocompatibility, and is non-toxic to mammalian cells. Incorporating electrostatic interactions in non-viral vectors enhance the vector permeability. This work focuses on two parts. Firstly, cationic chitosan derivatives were synthesized using quarternary ammonium and phosphonium groups. This was achieved by coupling carboxylic acid ligands with these quarternary groups to chitosan through an amide bond. The carboxylic acid ligands were synthesized from 4-methylbenzoic acid and either triethyl phosphine or triethyl amine. The ligand was then attached to chitosan through an amide …

Synthesis Of Modified Nanocomposite Material And Its Use On Removal Of Cesium Fromaqueous Media, Bi̇lal Çeti̇n, Mustafa Özcan, Bektaş Karakelle

Turkish Journal of Chemistry

A nanocomposite containing Fe3O4, chitosan (Ch), and hexacyanoferrate (HCF) was synthesized in the form of powder. The physicochemical properties of this nanocomposite are determined using different techniques including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM). The existence of Cs (Cs) ions onto the surface of the nanocomposite was verified by dispersive X-ray spectroscopy (EDX). FTIR spectra confirmed that the nanocomposite was well coordinated. The batch technique was applied to evaluate the influences of initial pH value, temperature, contact time, shaking rate, initial Cs concentration, and competing cations on the efficiency of Cs …

Preparation, Assessment, And Swelling Study Of Amphiphilic Acrylic Acid/Chitosan-Based Semi-Interpenetrating Hydrogels, Mohammad Reza Jozaghkar, Amir Sepehrianazar, Farshid Ziaee, Fakhrosadat Mirtaleb

Turkish Journal of Chemistry

The aim of this study was to synthesize amphiphilic semi-IPN hydrogels based on acrylic acid (AA) and chitosan (CS) using AIBN as an initiator and N,N?methylene bis acrylamide as a crosslinking agent. The swelling behavior of the hydrogels was evaluated at a variety of pH values, temperature, the salinity of media and time, and the swelling mechanism was investigated using Fickian diffusion and Schott's 2nd-order-kinetics models. FTIR spectroscopy was used to confirm the synthesis of AA/CS hydrogel. The swelling results showed that, in the acidic media, as the CS content increase the hydrogel swelling ratio reduces. It was found that …

Drug Delivery System For Controlled Release Of Empagliflozin From Alginate-Chitosannanocarrier System, Nasim Ramazanzadeh, Nosrat O. Mahmoodi

Turkish Journal of Chemistry

biocompatible nanocarrier system was prepared in this research through the reaction of calcium alginate (CA) with chitosan (CS). The structure of developed nanocarriers (CS-CA) was characterized by thermogravimetric analysis (TGA), Fourier transforms infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) atomic force microscopy (AFM), and transmission electron microscopy (TEM). Swelling properties of CS-CA and CA, and their ability for loading and in vitro release of empagliflozin (EMP) were also investigated. The results showed the higher loading capacity of CS-CA compared to CA. For both nanocarriers, the drug release was higher at neutral pH (7.4 and 6.8) …

The Investigation Of Parameters Affecting Ibrutinib Release From Chitosan/ Tripolyphosphate/Carbon Nanofiber Composite Microspheres, Canan Armutcu

Turkish Journal of Chemistry

This study described the performance of carbon nanofiber modified chitosan (CNF@CS) composite microspheres for the controlled release of the Ibrutinib (IBR) drug. The surface morphology, particle sizes, and functional group contents of the microspheres were characterized by attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron, and optical microscopy measurements. The obtained data demonstrated that the addition of CNF to the microsphere increased the encapsulation efficiency of the IBR while allowing the controlled and gradual release of the drug. In terms of the encapsulation efficiency and drug release rate, IBR@CS/TPP/CNF microspheres, achieving drug encapsulation efficiency of 83.09%, have the most …

Copper Nanoparticles In-Situ Anchored On Nitrogen-Doped Carbon For High-Efficiency Oxygen Reduction Reaction Electrocatalyst, Hui-Fang Yuan, Yue Zhang, Xing-Wu Zhai, Li-Bing Hu, Gui-Xian Ge, Gang Wang, Feng Yu, Bin Dai

Journal of Electrochemistry

Compared with noble metal platinum (Pt)-based catalysts, inexpensive non-noble metal electrocatalysts have attracted extensive attention for oxygen reduction reaction (ORR). Herein, chitosan as a kind of biomass resource rich in nitrogen and carbon was used to prepare nitrogen-doped carbon (N-C) and N-C in-situ anchored by copper nanoparticles (Cu/N-C). The as-obtained N-C and Cu/N-C nanoparticles were successfully used as non-noble eletrocatalysts tested for ORR. Compared with the N-C, the Cu/N-C showed the high surface area of 607.3 m 2·g-1 with the mean pore size of 2.5 nm and the pore volume of 0.40 cm3·g-1. The most positive Gibbs free …

Preparation And Evaluation Of Crocetin-Coated Biodegradable Polymer On Top Of Magnetite Nanoparticles For Their Anticancer Effects, Sulafa Saeed Abdelhalim Ibrahim

Theses

Liver cancer is still one of the leading causes of cancer-related deaths worldwide. This is due to many reasons including lack of effective drugs, late diagnosis of this type of cancer due to the overlapping of symptoms with many other liver diseases, and lack of effective screening tests. Targeted drug delivery systems offer many promising advantages compared to conventional chemotherapy. Targeted delivery will mitigate the bad side effects of chemotherapy such as drug resistance, low therapeutic value since the drug mostly will be administered through an IV affecting healthy and cancer cells alike, and that leads us to an important …

Synthesis Of Composites From Cellulose, Chitosan, And Ciprofloxacin Hci Encapsulated In Sporopollenin Capsules, Mark Mitmoen

Master's Theses (2009 -)

In order to be effective dressings for the treatment of infected wounds in the battlefield, it is essential that composite materials made from the biopolymers Cellulose and Chitosan contain broad-spectrum antibiotic drugs. These drugs must first be encapsulated into microcapsules in order to protect them from the manufacturing process, ensuring that they remain in a usable form in the final product. Here we demonstrate the successful encapsulation of Ciprofloxacin HCl into Sporopollenin Exine Capsules (SEC) to produce Cipro@SEC, followed by incorporation of Cipro@SEC into a polymer composite consisting of a mixture of Cellulose and Chitosan dissolved in 1-butylmethylimidazolium chloride, an …

Bentonite Reinforced Chitosan Scaffold: Effect Of Bentonite Exfoliation On Scaffold Properties, Soma Chakraborty, Cristine Joy M. Pimentel

Chemistry Faculty Publications

Chitosan is under investigation as biodegradable scaffolding material for tissue engineering. Crosslinked chitosan alone cannot form a self-supporting scaffold hence it needs reinforcement. The group reported fabrication of chitosan scaffolds reinforced by exfoliated and non-exfoliated bentonite and compared their properties. Scaffolds were fabricated by freeze-drying technique. Bentonite was exfoliated by allowing it to swell in water for a certain time interval. XRD profile showed that swelling reduced the crystallinity of bentonite. Both types of bentonite dispersed well in the chitosan matrix and imparted structural stability to the scaffolds. Scaffolds had interconnected pores, apparent porosity of scaffold with exfoliated bentonite was …

Chitosan Curcumin Film As A Sensor For Detection Of O-Nitrophenol And Fluoride Ion Using Fluoresce Quenching Technique, Soma Chakraborty, Andrea Paola D. Ilagan

Chemistry Faculty Publications

Curcumin was immobilized in chitosan films fabricated by solvent casting method. The amount of curcumin immobilization was more when methanol was used as a solvent to dissolve curcumin than the butanol solvent. The maximum amount of curcumin immobilized per gram of chitosan film was 0.023 g. Immobilized curcumin was not released back in water even after prolong contact of the films with water. Fluorescence intensity of the films got quenched when these films were in contact with an aqueous solution of o-nitrophenol (ONP) and sodium fluoride (NaF). The extent of quenching depended on the concentration of these attributes. Fluorescence intensity …

Evaluation Of A Novel Nanocrystalline Hydroxyapatite Powder And A Solid Hydroxyapatite/Chitosan-Gelatin Bioceramic For Scaffold Preparation Used As A Bone Substitute Material, Sharmin Rahman, Kazi Hanium Maria, Mohammad Saif Ishtiaque, Arijun Nahar, Harinarayan Das, Sheikh Manjura Hoque

Turkish Journal of Chemistry

Artificially fabricated hydroxyapatite (HAP) shows excellent biocompatibility with various kinds of cells and tissues which makes it an ideal candidate for a bone substitute material. In this study, hydroxyapatite nanoparticles have been prepared by using the wet chemical precipitation method using calcium nitrate tetra-hydrate [Ca(NO$_{3})_{2}$.4H$_{2}$O] and di-ammonium hydrogen phosphate [(NH$_{4})_{2}$HPO$_{4}$] as precursors. The composite scaffolds have been prepared by a freeze-drying method with hydroxyapatite, chitosan, and gelatin which form a 3D network of interconnected pores. Glutaraldehyde solution has been used in the scaffolds to crosslink the amino groups ($\vert $NH$_{2})$ of gelatin with the aldehyde groups ($\vert $CHO) of chitosan. …

Box-Behnken Design For Removal Of Uranium(Vi) From Aqueous Solution Using Poly(Ethylene Glycol) Based Dicationic Ionic Liquid Impregnated Chitosan, Süleyman İnan, Taşkin Mumcu, Serap Seyhan Bozkurt

Turkish Journal of Chemistry

Poly(ethylene glycol) bis(methylimidazolium) di[bis(trifluoromethylsulfonyl)imide] was synthesized as an ionic liquid and impregnated onto chitosan. The removal of uranium(VI) ions from aqueous solution was investigated with batch sorption tests using ionic liquid impregnated chitosan. Response surface methodology based on 3 level Box-Behnken design was applied to analyze the effect of initial pH (4-6), initial concentration (20-60 mg L$^{-1})$, contact time (15-105 min), and temperature (30-50 $^{\circ}$C C) on the uptake capacity of uranium(VI). Main effect of initial concentration, quadratic effect of contact time, and dual effect of initial pH and contact time were found statistically significant based on analysis of variance …

Recent Advances In The Application Of Carbohydrates As Renewable Feedstocks For The Synthesis Of Nitrogen-Containing Compounds, S. Iraj Sadraei, Brent St Onge, John F. Trant

Chemistry and Biochemistry Publications

Carbohydrates, in the form of chitin, chitosan and cellulose, are one of the most available, renewable, and sustainable chemical feedstocks. Their conversion to biofuels, fine chemicals, and industrially-relevant monomers is becoming increasingly viable and promising as innovation decreases the price of this technology, and climate change and the price of fossil fuels increases the social and economic costs of using traditional feedstocks. In recent years, carbohydrates have been increasingly used as sources for nitrogen-containing fine chemicals. This chapter, with 86 references, provides a brief overview of the conversion of carbohydrate biomass to the standard hydrocarbon and oxygen-containing derivatives, and then …

Pva/Chitosan/Silver Nanoparticles Electrospun Nanocomposites: Molecular Relaxations Investigated By Modern Broadband Dielectric Spectroscopy, Mohammad K. Hassan, Ahmed Abukmail, Alaa J. Hassiba, Kenneth A. Mauritz, Ahmed A. Elzatahry

Faculty Publications

In this study, we used broadband dielectric spectroscopy to analyze polymer nanofibers of poly(vinyl alcohol)/chitosan/silver nanoparticles. We also studied the effect of incorporating silver nanoparticles in the polymeric mat, on the chain motion dynamics and their interactions with chitosan nanofibers, and we calculated the activation energies of the sub-T_g relaxation processes. Results revealed the existence of two sub-T_g relaxations, the first gets activated at very low temperature (−90 °C) and accounts for motions of the side groups within the repeating unit such as –NH₂, –OH, and –CH₂OH in chitosan and poly(vinyl alcohol). The second …

Synthesis, Characterization, And Applications Of Ammonium/Phosphonium Chitosan Derivatives For Investigative Dna Interactions, Quinton Kirk Wyatt

MSU Graduate Theses

Chitosan is examined as a non-viral vector capable of efficient gene delivery due to its favorable properties such as biodegradability, biocompatibility, and is non-toxic to mammalian cells. Cell modifications and vector permeability are enhanced in non-viral vectors that incorporate electrostatic interactions. This work synthesizes cationic (N⁺, P⁺) chitosan derivatives, to enhance electrostatic interactions towards nucleotides, using amide coupling agents EDC and HOBt. The final chitosan derivatives will bear cationic functional groups (N⁺, P⁺) with various alkyl groups (Me, Et, Pr, Ph) to examine their affinities to nucleotides and antifungal properties. mPEG grafted …

Nmr Line Shape Analysis Of A Multi-State Ligand Binding Mechanism In Chitosanase, Shoko Shinya, Mariana G. Ghinet, Ryszard Brzezinski, Kyoko Furuita, Chojiro Kojima, Sneha Shah, Evgeni Kovrigin, Tamo Fukamizo

Chemistry Faculty Research and Publications

Chitosan interaction with chitosanase was examined through analysis of spectral line shapes in the NMR HSQC titration experiments. We established that the substrate, chitosan hexamer, binds to the enzyme through the three-state induced-fit mechanism with fast formation of the encounter complex followed by slow isomerization of the bound-state into the final conformation. Mapping of the chemical shift perturbations in two sequential steps of the mechanism highlighted involvement of the substrate-binding subsites and the hinge region in the binding reaction. Equilibrium parameters of the three-state model agreed with the overall thermodynamic dissociation constant determined by ITC. This study presented the first …

Synthesis And Characterization Of Magnetic Amidoximated Chitosan-G Poly(Polyacrylonitrile)/Laponite Rd Nanocomposites With Enhanced Adsorption Capacity For Cu$^{2+}$, Gholam Reza Mahdavinia, Ebrahim Shokri

Turkish Journal of Chemistry

Magnetic amidoximated nanocomposites based on a combination of chitosan and magnetic laponite RD were prepared and examined for the removal of Cu$^{2+}$ from aqueous solutions. Magnetic laponite RD was prepared by an in situ method. In order to prepare magnetic amidoximated nanocomposites, acrylonitrile was grafted to chitosan in the presence of magnetic laponite RD. Then the nitrile pendants on magnetic chitosan-g-polyacrylonitrile/laponite RD (mChtioPANLap) were converted to amidoxime groups. We developed a polyamidoximated magnetic nanocomposite based on a mixture of chitosan/laponite RD, possessing a high adsorption capacity for Cu$^{2+}$. By introducing magnetic laponite RD the adsorption capacity of nanocomposites for Cu$^{2+}$ …

Improvement Of Electrochemical And Structural Properties Of Polycarbazole By Simultaneous Electrodeposition Of Chitosan, Di̇dem Balun Kayan, Veysel Polat

Turkish Journal of Chemistry

Polycarbazole/chitosan composite materials were synthesized electrochemically at various loadings of chitosan (Chi). Their electrochemical, structural, thermal, and morphological characterizations were investigated by cyclic voltammetry, chronoamperometry, electrochemical impedance spectroscopy, Fourier transform infrared spectroscopy, thermal gravimetry, and scanning electron microscopy. Further electrical conductivity was measured using a four-point probe technique. The electrochemical results showed that the electrical conductivity of the polymeric composite film was increased by increasing the amount of Chi in the electrolyte medium. The as-prepared composite films exhibited enhanced electrical conductivity and structural properties of polycarbazole due to the presence of Chi in the composite films.

Mutlifunctional Platforms For Gene And Drug Delivery For Cancer Therapy, Jeffery J. Ambrose Jr.

Doctoral Dissertations

The National Cancer Institute and the American Cancer Society estimate that 1.6 million new cancer incidences and over half a million cancer related deaths occur annually [1][2]. Cancer the second most common cause of death in the United States [1], [2]. Although the causes of cancer can vary depending on cell type, all or almost all instances of cancer arise from a mutation or from an abnormal activation of the cellular genes that control cell growth and mitosis [3].

Treatment of a given cancer type depends on the subtype, stage and progression of the cancer. Varieties of cancer therapy include …

Characterization Of Physicochemical And Thermal Properties Of Chitosan And Sodium Alginate After Biofield Treatment, Snehasis Jana, Mahendra Kumar Trivedi, Rama Mohan Tallapragada, Alice Branton, Dahryn Trivedi, Gopal Nayak, Rakesh K. Mishra

Mahendra Kumar Trivedi

Electrochemical Monitoring Of The Interaction Between Mitomycin C And Dna At Chitosan--Carbon Nanotube Composite Modified Electrodes, Pembe Ece Canavar, Ece Ekşi̇n, Kadri̇ye Arzum Erdem Gürsan

Turkish Journal of Chemistry

Single-walled carbon nanotube (CNT) and chitosan composite (chitosan*CNT) based sensors were developed as DNA biosensors, and then they were applied for electrochemical investigation of the interaction between the anticancer drug mitomycin C (MC) and DNA. The oxidation signals of MC and guanine were monitored before and after the interaction process by differential pulse voltammetry (DPV). The DPV results were in good agreement with those of electrochemical impedance spectroscopy (EIS). Analytical parameters such as DNA concentration, MC concentration, and MC interaction time with DNA were optimized. The detection limits were 6.85 \mu g/mL for DNA and 11.01 \mu g/mL for MC.

Chitosan-Cellulose Composite For Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, And Biocompatibility, April Harkins, Simon Duri, Luther C. Kloth, Chieu D. Tran

Clinical Lab Sciences Faculty Research and Publications

Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects. In this study, the novel composites containing CS and cellulose (CEL) (i.e., [CEL + CS]), which we have previously synthesized using a green and totally recyclable method, were investigated for their antimicrobial activity, absorption of anticoagulated whole blood, anti-inflammatory activity through the reduction of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and the biocompatibility with human fibroblasts. The [CEL + CS] composites were found to …

Design And Development Of A Novel Glucose Biosensor Based On The Ferrocene-Functionalized Fe3O4 Nanoparticles/Carbon Nanotubes/Chitosan Nanocomposite Film Modified Electrode, Hua-Ping Peng, Dai-Jun Zha, Wei Chen, Ai-Lin Liu, Xin-Hua Lin

Journal of Electrochemistry

A novel platform for the fabrication of glucose biosensor was successfully constructed by entrapping glucose oxidase (GOD) in a ferrocene monocarboxylic acid-aminated Fe₃O₄ magnetic nanoparticles conjugate (FMC-AFNPs)/chitosan (CS)/multiwall carbon nanotubes (MWNTs) nanocomposite. The formation of FMC-AFNPs could effectively prevent the leakage of ferrocene and retain its electrochemical activity. This GOD/FMC-AFNPs/CS/MWNTs matrix provided a biocompatible microenvironment for retaining the native activity of the immobilized GOD. Moreover, the presence of MWNTs enhanced the charge-transport properties of the composite and facilitated electron transfer between the GOD and the electrode for the electrocatalysis of glucose. Under the optimal conditions the designed …

Synthesis And Study Of Chemo-Hydrothermally Derived Water-Soluble Chitosan And Chiosan-Metal Oxide Composites, Srijita Basumallick

Electronic Theses and Dissertations

Chitosan (CS) is a man-made sugar based biopolymer derived from chitin, the second most abundant natural polymer after cellulose. Chitin is sourced from crustacean species such as shrimps and crabs. The chemical structure of chitin contains N-Acetyl D-glucosamine monomer units which forms CS upon deacetylation. In CS, ?-(1-4) linked D-glucosamine units are randomly distributed. Approximately 75% - 80% sugar units contains primary amine groups in commercially available low molecular weight CS. Biodegradability, low toxicity, mucoadhesive and transfecting properties of CS polymer are attractive for applications as oral and nasal drug delivery systems. Chitosan polymer is water insoluble at neutral pH. …

Recyclable Synthesis, Characterization, And Antimicrobial Activity Of Chitosan-Based Polysaccharide Composite Materials, Chieu D. Tran, Simon Duri, April Harkins

Chemistry Faculty Research and Publications

We have successfully developed a simple and totally recyclable method to synthesize novel, biocompatible, and biodegradable composite materials from cellulose (CEL) and chitosan (CS). In this method, [BMIm⁺Cl⁻], an ionic liquid (IL), was used as a green solvent to dissolve and synthesize the [CEL+CS] composites. Since, the IL can be removed from the composites by washing them with water, and recovered by distilling the washed solution, the method is totally recyclable. Spectroscopic and imaging techniques including XRD, FTIR, NIR, and SEM were used to monitor the dissolution, to characterize and to confirm that CEL and CS …