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A Novel Supercritical Co2-Based Decellularization Method For Maintaining Scaffold Hydration And Mechanical Properties, Michael A. Matthews, Tarek Shazly, Rachel M. Handleton, Dominic M. Casali
A Novel Supercritical Co2-Based Decellularization Method For Maintaining Scaffold Hydration And Mechanical Properties, Michael A. Matthews, Tarek Shazly, Rachel M. Handleton, Dominic M. Casali
Faculty Publications
Decellularized tissues are commonly utilized as tissue engineering scaffolds. Decellularization by extended exposure to aqueous detergents can damage the microstructure or deposit cytotoxic residue. Supercritical carbon dioxide (scCO2) has been proposed for decellularization, but reportedly causes dehydration and scaffold embrittlement.
Presented herein is a novel decellularization method that preserves matrix hydration state and mechanical properties. Over 97% of the water in porcine aorta is maintained by presaturating scCO2 with water; however, complete decellularization was not attained by any process utilizing only scCO2. Instead, a novel hybrid method is presented that combines a brief (48 h) exposure of tissue to aqueous …
Stabilization Of Silicon And Germanium Based High Capacity Anodes For Lithium Ion Batteries, Kuber Mishra
Stabilization Of Silicon And Germanium Based High Capacity Anodes For Lithium Ion Batteries, Kuber Mishra
Theses and Dissertations
Lithium-ion batteries (LIBs) have been the driver of the widespread application of portable electronics. As the electronic devices have been more powerful and versatile, the pressing demand for higher energy density batteries have led the extensive explorations of novel materials for high capacity electrodes. Despite several breakthroughs in literature, the current state of art LIBs still uses the battery chemistry developed in early 1990s.The keys challenges for switching to other high capacity electrodes have been high cost, non-linear scalability and poorer electrochemical performance. This dissertation focusses on development of high capacity electrodes in order to increase the energy density of …
Fundamental Aspects Of A Novel Technology For Abatement Of Indoor Allergens, Odell Lendor Glenn Jr.
Fundamental Aspects Of A Novel Technology For Abatement Of Indoor Allergens, Odell Lendor Glenn Jr.
Theses and Dissertations
The overall goal of this research was to develop a novel approach to reduce the potency of certain asthma triggers, namely, proteins produced by pests or pets in indoor environments. The broad hypothesis of the research was that naturally occurring essential oils will demonstrate enhanced denaturing ability. In any indoor environment, allergens are bound to dry dust particles. In this work, the effectiveness of using dry ice and CO2 with potential for essential oils on dry allergenic proteins through CFD modeling and ELISA methods were evaluated.
There are three objectives central to this work. The first objective was to apply …
Combinatorial Study Of Oxidation Catalysts: Uncovering Synthesis-Structure-Activity Relationships, Kathleen B. Mingle
Combinatorial Study Of Oxidation Catalysts: Uncovering Synthesis-Structure-Activity Relationships, Kathleen B. Mingle
Theses and Dissertations
High throughput experimentation (HTE) in catalysis has proven useful in expediting materials discovery via parallelized synthesis, characterization, and testing of candidate materials. However, even in a high-throughput manner, the combinatorial explosion of relevant parameters far exceeds our ability to study. To further complicate the problem, a large time investment and great deal of characterization is often required to build an in-depth understanding of catalytic materials. It follows that the field of heterogeneous catalysis is rich with examples of catalytic systems that have been developed using trial and error efforts for which a lot is known but context is lacking. Techniques …
Understanding Early Amyloid-Ss Aggregation To Engineer Polyacid-Functionalized Nanoparticles As An Inhibitor Design Platform, Nicholas Vander Munnik
Understanding Early Amyloid-Ss Aggregation To Engineer Polyacid-Functionalized Nanoparticles As An Inhibitor Design Platform, Nicholas Vander Munnik
Theses and Dissertations
Alzheimer’s disease (AD) is characterized by the presence of amyloid-ß (Aß) protein aggregates in the brains of those afflicted. This protein aggregates via a complex pathway to progress from monomers to soluble oligomers and ultimately insoluble fibrils. Due to the dynamic nature of aggregation, it has proven exceedingly difficult to determine the precise interactions that lead to the formation of transient oligomers. A statistical thermodynamic model has been developed to elucidate these interactions. Aß was simulated using fully-atomistic replica exchange molecular dynamics. We use an ensemble of 5 × 105 configurations taken from these simulations as input for a self-consistent …
Role Of Bed Design Characteristics On The Effective Thermal Conductivity Of A Structured Adsorbent, Pravin Bosco Charles Antony Amalraj
Role Of Bed Design Characteristics On The Effective Thermal Conductivity Of A Structured Adsorbent, Pravin Bosco Charles Antony Amalraj
Theses and Dissertations
This work evaluates the role of different design variables on the effective thermal conduction of a structured adsorbent bed for its possible application in a temperature swing adsorption (TSA) process. The structured adsorbent bed is represented by eight parallel layers of intercalated smooth and corrugated foils of a metal support coated with 13X zeolite resulting in the formation of parallel triangular channels. The variables investigated include the thickness of the adsorbent coating, thickness of the metal, nature of contacts between smooth and corrugated foils, type of metal, presence and magnitude of an air gap between the foils, difference in alignment …
Selective Deposition Of Platinum By Strong Electrostatic Adsorption Onto Cobalt- And Iron-Based Catalysts For Fischer-Tropsch Synthesis, Fahad A. Almalki
Selective Deposition Of Platinum By Strong Electrostatic Adsorption Onto Cobalt- And Iron-Based Catalysts For Fischer-Tropsch Synthesis, Fahad A. Almalki
Theses and Dissertations
Cobalt and iron based catalysts are commercially predominant for Fischer-Tropsch synthesis, Co-based catalysts for their stability, activity, and inactivity for the water gas shift reaction and Fe-based catalysts for their cheap cost, high light-olefins and alcohols selectivity, and tolerance to H2/CO ratio. These catalysts are structure sensitive with lower activity at nanoparticle sizes smaller than 6-8 nm. Co-based catalysts exhibit high activity, low CH4 selectivity, and high C5+ selectivity, while Fe-based catalysts are more selective to low-molecular-weight hydrocarbons such as olefins and alcohols. The reducibility of cobalt and iron is another important factor which may be key for improving their …
Development Of Bimetallic Catalysts For Dry Reforming Of Methane And Hydrogenation Of Succinic Acid, Jayson Michael Keels
Development Of Bimetallic Catalysts For Dry Reforming Of Methane And Hydrogenation Of Succinic Acid, Jayson Michael Keels
Theses and Dissertations
Advances in natural gas recovery have greatly impacted the global economy; the abundant supply of gas has revealed new opportunities and challenges in a wide range of markets within the fuels and chemicals industries. One such opportunity exists with the overabundance of gas from remote wells that is flared or emitted because of the high costs associated with transportation of a chemical with such a high molar volume. A possible solution is an on-site process to convert gas to higher value chemicals that are liquid at standard conditions, and can more easily be transported. As a first step, CO2 from …
Design, Synthesis, And Characterization Of Monometallic And Bimetallic Catalysts, Sonia Eskandari
Design, Synthesis, And Characterization Of Monometallic And Bimetallic Catalysts, Sonia Eskandari
Theses and Dissertations
Supported catalysts are used extensively in a variety of heterogeneously catalyzed reactions for industrial processes. Techniques for preparing supported noble metal catalysts are typically chosen to achieve high metal dispersions in order to obtain high activity for a given metal loading. Enhancing the catalytic performance of heterogeneous catalysts can be done by increasing active site count as well as modification of the physico-chemical characteristics of the catalyst material. For supported metal nanoparticles this can be achieved by decreasing particle size, thus increasing dispersion or metal utilization on the surface of the particles, while modification of metal properties can be attained …
Hydrodeoxygenation Of Acetic Acid Using Monometallic And Bimetallic Catalysts Supported On Carbon, José Luis Contreras Mora
Hydrodeoxygenation Of Acetic Acid Using Monometallic And Bimetallic Catalysts Supported On Carbon, José Luis Contreras Mora
Theses and Dissertations
Heterogeneous catalytic hydrodeoxygenation (HDO) of biomass-derived feeds is a deoxygenation process that is of highly interest. Carboxylic acids are one of the main components of bio-oils and acetic acid is one of the most abundant of these carboxylic acids. This acid is rich in oxygen, therefore a lot of research to produce fuel and other valuable chemicals such as ethanol is of interest.
This dissertation explores the gas-phase catalytic HDO of AA over catalysts supported on activated carbon (Cp-97). Temperature-dependent conversion and selectivity were studied at 1 atm from 200-4000C with an AA concentration of 1.1% and 20% …
Dynamic Simulation Of A Solar Powered Hybrid Sulfur Process For Hydrogen Production, Satwick Boddu
Dynamic Simulation Of A Solar Powered Hybrid Sulfur Process For Hydrogen Production, Satwick Boddu
Theses and Dissertations
The Hybrid Sulfur process is a thermo-electrochemical cycle used to produce hydrogen from water. The process requires a high temperature energy source for H2SO4 decomposition with temperature reaching 800°C. This step is followed by SO2 - depolarized water electrolysis. Using solar energy as the high temperature energy source allows for efficient environmentally friendly production of hydrogen. This method is an alternative to traditional photovoltaic electrolysis for hydrogen production. Making the process economically competitive is a major challenge. Operating the process with changes in the availability of solar energy also increases process complexity. The dependence of the process on solar energy …