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Interactions Of Nitric Oxide And Superoxide Pathways In Hyperglycemic Endothelial Cells, Steven Clay Rogers
Interactions Of Nitric Oxide And Superoxide Pathways In Hyperglycemic Endothelial Cells, Steven Clay Rogers
Graduate Theses and Dissertations
Cardiovascular complications arising from diabetic hyperglycemia represents one of the leading causes of death and greatest public health challenges of modern societies. Despite state-of-the-art glucose control, diabetic patients remain at a markedly increased risk of cardiovascular disease. The loss of endothelial function (the development of diabetic endothelial dysfunction) has been implicated in the development of numerous diabetic cardiovascular diseases. The endothelial cell produces many vasoactive substances, hormones and cytoprotective biological factors. Endothelial cells are also involved in and affected by the initiation of inflammatory responses through the release and interaction of cytokines and other immune system molecules. Therefore, regulation of …
In Vitro Selection Of Aptamers Against Avian Influenza Virus H5n1, Jingjing Zhao
In Vitro Selection Of Aptamers Against Avian Influenza Virus H5n1, Jingjing Zhao
Graduate Theses and Dissertations
Over $10 billion losses in the poultry industry were caused by avian influenza (AI) so far. Rapid and specific detection of avian influenza virus is urgently needed with the concerns over the outbreaks of highly pathogenic H5N1 influenza virus and cases of animal and human infection. Aptamers are oligonucleic acid or peptide molecules that bind a specific target molecule with good affinity. They show better thermal stability than antibodies. The goal of this research was to select DNA-aptamers as the specific recognition element of AI H5N1virus to be used in detection assays specific for field application. In this study, Systematic …
Mechanism Of Transcriptional Suppression Of A Phytochrome A Epiallele In Arabidopsis Thaliana, Gulab D. Rangani
Mechanism Of Transcriptional Suppression Of A Phytochrome A Epiallele In Arabidopsis Thaliana, Gulab D. Rangani
Graduate Theses and Dissertations
Cytosine methylation in DNA is an integral part of epigenetically controlled regulatory networks in eukaryotes. Both plants and vertebrates display DNA methylation in the gene coding region; however, its role in gene expression is not well understood. Gene promoter, on the other hand, remains largely unmethylated. Acquisition of methylation in promoter results in transcriptional suppression of the gene. The goal of this research is to study the effect of coding region methylation in gene expression using a unique gene model, phyA'. phyA' is a transcriptionally suppressed epiallele of the Arabidopsis thaliana Phytochrome A gene, which contains methylation in CG sites …
Effects Of Lactate Dehydrogenase Haplotypes And Body Condition On Beef Cow Production, Olfat Taleb Alaamri
Effects Of Lactate Dehydrogenase Haplotypes And Body Condition On Beef Cow Production, Olfat Taleb Alaamri
Graduate Theses and Dissertations
Lactate dehydrogenase (LDH) catalyzes the conversion of the pyruvate to lactate (forward) or lactate to pyruvate (reverse) in the last step of glycolysis. Objectives were to document the effects of LDH haplotypes and its SNPs, found in the promoter and coding sequence site, and body condition on beef cow production. Four single nucleotide polymorphisms (SNP) of LDH-B and Five single nucleotide polymorphisms of LDH-A were detected. Eight haplotypes of LDH-B were assigned with the same order of SNPs: G-348A, A-261G, N-222D, and C541A and four haplotypes of LDH-A were assigned with the same order of SNPs: T-327G, D-263C, G390A, A406G, …
Characterization And Functional Regulation Of Bioactive Peptides In Avian Macrophages And Heterophils, Lakshmi Kannan
Characterization And Functional Regulation Of Bioactive Peptides In Avian Macrophages And Heterophils, Lakshmi Kannan
Graduate Theses and Dissertations
Oligopeptides and low molecular weight polypeptides play central roles as effectors and signal transducers acting as hormones, neurotransmitters, growth factors, toxins, and antimicrobial factors that are important for the survival of the organism. Owing to the ubiquitous involvement of peptides in many key regulatory processes, we have been interested to identify native peptides in different cells and tissues and understand their functions. To conduct our studies, we used avian macrophages and heterophils as models of specialized cells which constitute central components of innate immunity. These studies involved (a) qualitative identification and characterization of the peptides associated with high intensity mass …
The Role Of Multiple Ccaat-Binding Factors In Candida Albicans Gene Expression, Lashall Lynn Bates
The Role Of Multiple Ccaat-Binding Factors In Candida Albicans Gene Expression, Lashall Lynn Bates
Graduate Theses and Dissertations
The CCAAT-binding factor is a heterooligomeric transcription factor that is evolutionarily conserved in eukaryotes. In yeast, the DNA-binding component that interacts with the CCAAT consensus sequence in promoters consists of the subunits termed Hap2p, Hap3p and Hap5p. In yeast and fungi, a fourth subunit, Hap4p, is required for regulating gene expression. The goal of this research is to understand the function of the Candida albicans CCAAT-binding factor and how it relates to virulence and pathogenicity. C. albicans is a human opportunistic pathogen responsible for a variety of mucosal and systemic infections that result in significant morbidity and mortality, particularly in …
Preparation, Separation, Purification, Characterization And Human Cell Line Anti-Cancer Evaluation Of Rice Bran Peptides, Arvind Kannan
Preparation, Separation, Purification, Characterization And Human Cell Line Anti-Cancer Evaluation Of Rice Bran Peptides, Arvind Kannan
Graduate Theses and Dissertations
Bioactive compounds are revolutionizing the nutritional and medicinal world with their inherent disease-fighting properties. A wide range of functional groups fall under the category of imparting health benefits. Compounds from both animal and plant origins have been generated as bioactive agents that have opened up new vistas for alternative medicine and natural healing. For example, in a debilitating disease like cancer, these compounds can act to suppress or delay the underlying pathology over and above the conventional treatment strategies involving drugs or chemotherapy. In other words conventional and invasive therapy, although still considered appropriate at certain stages of cancer, their …
The Membrane Interface Of Chloroplast Signal Recognition Particle-Dependent Protein Targeting, Naomi Jane Marty
The Membrane Interface Of Chloroplast Signal Recognition Particle-Dependent Protein Targeting, Naomi Jane Marty
Graduate Theses and Dissertations
A novel signal recognition particle (SRP) found in the chloroplast (cpSRP) works in combination with the cpSRP receptor, cpFtsY, to facilitate the post-translational targeting of a family of nuclear-encoded thylakoid proteins to the Alb3 translocase in thylakoid membranes. Work here focused on understanding events at the membrane that take place to ensure targeting of the cpSRP-dependent substrate to Alb3. Specifically, we sought to understand the structural and functional role of membrane binding by cpFtsY, a protein that exhibits the ability to partition between the membrane (thylakoid) and soluble (stroma) phase during protein targeting. We also sought to understand whether a …