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A Fractal Art Approach To The Three-Body Problem, Charles F. Babbs
A Fractal Art Approach To The Three-Body Problem, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
This preliminary study explores a new search strategy for identifying relatively stable vs. unstable solutions to the planar three-body problem in astrophysics, starting from the perspective of computer-generated art. Here classical Newtonian accelerations, speeds, and positions of all three bodies in a fixed plane are calculated. All three bodies are stationary at time zero, and the fate of the system is classified as reflecting either a bound stable orbit, a likely collision, or the ejection of one body. The initial position of one of the three bodies is varied in the image plane, and the outcome coded as one of …
Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen
Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen
Purdue Journal of Service-Learning and International Engagement
Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …
Quantification Of Intervertebral Disc Strain From High-Resolution Ultrasound Imaging During Dynamic Loading, Diya Sakhrani
Quantification Of Intervertebral Disc Strain From High-Resolution Ultrasound Imaging During Dynamic Loading, Diya Sakhrani
Discovery Undergraduate Interdisciplinary Research Internship
High-resolution ultrasound imaging employs high-frequency sound waves that can be used to noninvasively visualize the structures within the body, facilitating medical diagnosis without the need for open surgery. The widespread utilization of ultrasound is attributed to its affordability, non-invasive characteristics, and use of non-ionizing radiation. Nevertheless, ultrasound is prone to artifacts originating from the surrounding environment, gas-liquid interfaces, or dense tissue. These artifacts are common in ultrasound images and can cause dropout, noise, and degraded resolution. In this study we analyzed intervertebral disc (IVD) strain during two axial compression testing cycles of bovine intervertebral discs with a 2-dimensional direct deformation …
Characterizing Intervertebral Disc Strain Under Dynamic Loading Conditions Using Ultrasound Texture Analysis, Radhika Kulkarni
Characterizing Intervertebral Disc Strain Under Dynamic Loading Conditions Using Ultrasound Texture Analysis, Radhika Kulkarni
Discovery Undergraduate Interdisciplinary Research Internship
Herniated discs in the spine are a significant patient burden, with potential links to lower back and leg discomfort and a considerable impact on daily life. These discs, located between spinal vertebrae, are comprised of the annulus fibrosus (AF) and the nucleus pulposus (NP). Herniations happen when the NP protrudes through a full-thickness annular tear, possibly compressing spinal nerves. The mechanical factors underlying herniated discs are poorly understood, necessitating research into these mechanisms and accessible diagnostic techniques. Our study employs high-resolution ultrasound and texture correlation to quantify strain patterns in intervertebral discs during dynamic loading.
A motion segment from the …
The Effects Of Engineering Summer Camps On Middle And High School Students’ Engineering Interest And Identity Formation: A Multi-Methods Study, Timothy Robinson, Adam Kirn, Jenny Amos, Indira Chatterjee
The Effects Of Engineering Summer Camps On Middle And High School Students’ Engineering Interest And Identity Formation: A Multi-Methods Study, Timothy Robinson, Adam Kirn, Jenny Amos, Indira Chatterjee
Journal of Pre-College Engineering Education Research (J-PEER)
This multi-methods study explores changes in engineering interest and identity of middle and high school students (n = 79) attending introductory-level engineering summer camps at a large western land grant university. Middle school is a critical time when student interest, identity, and subsequently career choice begin to emerge and hence it is important that at this age students are given accurate information about engineering majors in college and future career opportunities in engineering. Data were collected over a period of two years in six summer camps. Three separate populations of middle and high school students participated in the summer …
Scanning Electron Microscopy Analysis Of Murine Renal, Aortic, And Cardiac Tissue, Sarah E. Grev, Luke E. Schepers, Jennifer Anderson, Craig J. Goergen
Scanning Electron Microscopy Analysis Of Murine Renal, Aortic, And Cardiac Tissue, Sarah E. Grev, Luke E. Schepers, Jennifer Anderson, Craig J. Goergen
Discovery Undergraduate Interdisciplinary Research Internship
Scanning electron microscopy (SEM) is a tool that provides detailed insight into objects invisible to the human eye. As the name suggests, an electron beam is used to create an image down to the nanometer scale. The beam focuses on the surface of a sample using lenses in the electron column. In this project, we use SEM to study three types of murine tissue. First, we examine the glomerulus, found in the kidney, that is primarily responsible for filtering blood. Following a left renal vein (LRV) stenosis, SEM is used to observe changes to the glomeruli. Differences in the left …
Methods To Study Activity Dependent Protein Synthesis In Autism Spectrum Disorder, Megan Webb, Karin F K Ejendal, Tamara L. Kinzer-Ursem
Methods To Study Activity Dependent Protein Synthesis In Autism Spectrum Disorder, Megan Webb, Karin F K Ejendal, Tamara L. Kinzer-Ursem
Discovery Undergraduate Interdisciplinary Research Internship
It is estimated by the World Health Organization that 1 in 100 children have autism spectrum disorder (ASD), a condition characterized by neurological differences that may impact a person’s learning or behavior. Clinically, ASD symptoms are alleviated with behavioral or pharmacological therapies, however, not all patients respond to these interventions. Deep brain stimulation (DBS) is a promising treatment of Parkinson’s disease that could also be effective in treating ASD. SynGAP1 is a protein involved in neuronal action that is crucial for regulating synaptic plasticity. Mutations in the SYNGAP1 gene causing haploinsufficiency can result in the manifestation of ASD symptoms. This …
Raman Spectroscopy - An Analytical Tool For Biologics, Cindy Mayorga, Shreya Milind Athalye, Mohit Verma
Raman Spectroscopy - An Analytical Tool For Biologics, Cindy Mayorga, Shreya Milind Athalye, Mohit Verma
Graduate Industrial Research Symposium
Raman Spectroscopy (RS) is a non-invasive technique that analyses biomolecules qualitatively and quantitatively. Raman spectroscopy measures the inelastic scattering of light due to molecular vibrations. It can be applied to liquid, solid, or semi-solid forms of the biological sample reducing the sample preparation measures. The minimal sample preparation and non-invasive nature of Raman Spectroscopy can be applied in developing a Process analytical technology (PAT) tool and as a diagnostic tool. We demonstrated qualitative and quantitative measurements of biologics with Raman spectroscopy through our previous studies. Our results indicate that RS distinguishes various Gram-positive and Gram-negative bacteria, fungi, and a mixture …
The Next-Gen Crop Nutrient Stress Identification With High-Precision Sensing Technology In Digital Agriculture, Zhihang Song, Ziling Chen, Xing Wei, Jian Jin
The Next-Gen Crop Nutrient Stress Identification With High-Precision Sensing Technology In Digital Agriculture, Zhihang Song, Ziling Chen, Xing Wei, Jian Jin
Graduate Industrial Research Symposium
Crop yields are facing significant losses from nutrient deficiencies. Over-fertilizing also has negative economic and environmental impacts. It is challenging to optimize fertilizing without an accurate diagnosis. Recently, plant phenotyping has demonstrated outstanding capabilities in estimating crop traits. As one of the leading technologies, LeafSpec, provides high-quality crop image data for improving phenotyping quality. In this study, novel algorithms are developed for LeafSpec to identify crop nutrient deficiencies more accurately. Combined with UAV system, this technology will bring growers a robust solution for fertilizing diagnosis and scientific crop management.
Sea-Phages Course-Based Undergraduate Research Experience For Creating A Biotechnology Workforce Development Pipeline, Daphne Fauber, Kari Clase, Carol Weaver
Sea-Phages Course-Based Undergraduate Research Experience For Creating A Biotechnology Workforce Development Pipeline, Daphne Fauber, Kari Clase, Carol Weaver
Graduate Industrial Research Symposium
Purdue University has been a member of the SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) program since 2011. This program, created in conjunction with the Howard Hughes Medical Institute (HHMI), facilitates undergraduate curriculum for the authentic discovery of novel bacteriophages within the classroom. Since joining the program, undergraduates at Purdue have harnessed wet lab and bioinformatics principles to contribute over 200 previously uncharacterized bacteriophages and 25 novel genomes to the wider scientific literature. The SEA-PHAGES classes at Purdue have resulted in tangible professional deliverables for students through conference presentations and publications. Student outcomes also include transferable skills …
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Purdue Journal of Service-Learning and International Engagement
EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …
Scandy: Simulating Realistic Human Scanpaths In Dynamic Real-World Scenes, Nicolas Roth, Martin Rolfs, Klaus Obermayer
Scandy: Simulating Realistic Human Scanpaths In Dynamic Real-World Scenes, Nicolas Roth, Martin Rolfs, Klaus Obermayer
MODVIS Workshop
No abstract provided.
Designing A Self-Regulating And Portable Heating Device For A Microfluidic Based Biosensor, Riya Mahajan
Designing A Self-Regulating And Portable Heating Device For A Microfluidic Based Biosensor, Riya Mahajan
Discovery Undergraduate Interdisciplinary Research Internship
Paper-based biosensors are powerful microfluidic analytical devices that are potentially useful for a wide range of applications, ranging from medical diagnostics to agricultural and environmental monitoring. Molecular diagnostics have limitations because they need to send samples back to a centralized laboratory, which increases the cost and turnaround time of the test. This project aims to create a simple-to-use, low-cost, and portable heating system that would facilitate the creation of a field-deployable paper-based analytical device that can incubate the sample at elevated temperatures for conducting isothermal molecular assays. Our design aims to miniaturize a commercial water bath and will be fabricated …
A Note From The Co-Editors, Jada C. Johnson
A Note From The Co-Editors, Jada C. Johnson
Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series
An introduction to the fifth issue of the third volume of Ideas Magazine, concerning the thoughts, experience, and work of Dr. Marcelo J.S. de Lemos.
Deep Learning Approach To Improved Image Quality For Medical Diagnostics, Olivia Loesch, Katie Leyba, Halyley Chan, Craig Goergen
Deep Learning Approach To Improved Image Quality For Medical Diagnostics, Olivia Loesch, Katie Leyba, Halyley Chan, Craig Goergen
Discovery Undergraduate Interdisciplinary Research Internship
The United Nation’s health-related Sustainable Development Goals are difficult to achieve in low- and middle-income countries due to workforce shortages and inadequate health surveillance systems. However, with the growth of artificial intelligence (AI) and computer algorithms, it is possible to apply AI to healthcare technologies to improve progress towards these UN standards. This project aims at using and improving computer algorithms and deep learning to aid in the extraction of important structural and functional information from murine carotid artery ultrasound and photoacoustic images. First, we created a large database of simulated photoacoustic images to optimize the algorithms. These images were …
A Review Of Mobile Apps For Chronic Kidney Disease Patients, Clarisse Zigan, Carl Russell Iii, Kirsten Wozniak, Kshaunish Soni
A Review Of Mobile Apps For Chronic Kidney Disease Patients, Clarisse Zigan, Carl Russell Iii, Kirsten Wozniak, Kshaunish Soni
The Journal of Purdue Undergraduate Research
No abstract provided.
Collision Tracking And Brain Mapping, Carl Russell Iii
Collision Tracking And Brain Mapping, Carl Russell Iii
The Journal of Purdue Undergraduate Research
No abstract provided.
Visualizing Bacteriophage Evolution Through Sequence And Structural Phylogeny Of Lysin A And Terminase Proteins: An Analysis Of Protein Structure Across Phage Clusters, Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam
Visualizing Bacteriophage Evolution Through Sequence And Structural Phylogeny Of Lysin A And Terminase Proteins: An Analysis Of Protein Structure Across Phage Clusters, Maansi Asthana, Alyssa Easton, Julia Mollenhauer, Sean Renwick, Anita Golpalrathnam
The Journal of Purdue Undergraduate Research
Understanding how genes evolve and persist is a critical part of viral genomics. Bacteriophages can provide unique insight about viral evolution because of their abundance and largely unexplored history. Traditionally, phylogenetic trees have used DNA sequence comparison to visualize evolutionary paths between organisms. However, DNA sequence similarity does not reflect key alterations to protein structure and therefore how the protein performs its function. Phylogenetic trees based on predicted protein structure could provide an alternative lens through which to view evolutionary paths. From each of the 10 largest clusters included in the Actinobacteriophage Database, three mycobacteriophage genomes were selected. Lysin A …
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Purdue Journal of Service-Learning and International Engagement
Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …
A Note From The Editor, Daphne Fauber
A Note From The Editor, Daphne Fauber
Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series
This piece is a letter from Daphne Fauber, the editor of this issue of Ideas. In the letter, the editor introduces the work of Dr. Paschalis Gkoupidenis as well as the moment in time in which his Visiting Scholars talk occurs.
Introduction To Neuromorphic Computing, Sadid R. Khan
Introduction To Neuromorphic Computing, Sadid R. Khan
Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series
Neuromorphic computing is an emerging field that has the potential to drastically influence every human’s life within the next decades. Neuromorphic computing explores the computing process of the brain and attempts to replicate it onto modern electronics. It offers improvements on current computer architecture, the von Neumann architecture, and will lead to more efficient computing, easier development of machine learning, and further integration of electronics and biology.
In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak
In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak
Purdue Journal of Service-Learning and International Engagement
EPICS is a service-learning design program run through Purdue University. It strives to teach students design skills through providing for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Biomedical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. William Sevick is an elementary school student with a congenital arm amputation. William and his family have been working with the BME team for the past three years designing assistive devices with the purpose of improving his actions in daily life such as eating, playing games, and riding his bike.
Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger
Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger
The Journal of Purdue Undergraduate Research
No abstract provided.
Comparison Of Machine Learning Models: Gesture Recognition Using A Multimodal Wrist Orthosis For Tetraplegics, Charlie Martin
Comparison Of Machine Learning Models: Gesture Recognition Using A Multimodal Wrist Orthosis For Tetraplegics, Charlie Martin
The Journal of Purdue Undergraduate Research
Many tetraplegics must wear wrist braces to support paralyzed wrists and hands. However, current wrist orthoses have limited functionality to assist a person’s ability to perform typical activities of daily living other than a small pocket to hold utensils. To enhance the functionality of wrist orthoses, gesture recognition technology can be applied to control mechatronic tools attached to a novel fabricated wrist brace. Gesture recognition is a growing technology for providing touchless human-computer interaction that can be particularly useful for tetraplegics with limited upper-extremity mobility. In this study, three gesture recognition models were compared—two dynamic time-warping models and a hidden …
Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation, Charles F. Babbs
Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
Accurate measurement of blood pressure in the presence of atrial fibrillation remains an open problem. The present study combines the techniques of stochastic mathematical modeling with physiological models of the systemic circulation, cuff, and arm (1) to explore mechanisms underlying both the lack of accuracy and the lack of precision in cuff-based arterial pressure measurements during atrial fibrillation and (2) to develop strategies to correct for errors. Both the cardiovascular system and the measurement technique are described using mathematics, including both numerical techniques and analytical probability theory. Preliminary results with numerical models suggested that, despite variability, average systolic pressures tend …
Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury, James K. Nolan, Tran N. H. Nguyen, Mara Fattah, Jessica C. Page, Riyi Shi, Hyowon Lee
Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury, James K. Nolan, Tran N. H. Nguyen, Mara Fattah, Jessica C. Page, Riyi Shi, Hyowon Lee
Weldon School of Biomedical Engineering Faculty Publications
Excessive glutamate release following traumatic spinal cord injury (SCI) has been associated with exacerbating the extent of SCI. However, the mechanism behind sustained high levels of extracellular glutamate is unclear. Spinal cord segments mounted in a sucrose double gap recording chamber are an established model for traumatic spinal cord injury. We have developed a method to record, with micro-scale printed glutamate biosensors, glutamate release from ex vivo rat spinal cord segments following injury. This protocol would work equally well for similar glutamate biosensors.
Identifying Extracellular Matrix Protein Turnover Rates For Tissue Engineers, Alita F. Miller
Identifying Extracellular Matrix Protein Turnover Rates For Tissue Engineers, Alita F. Miller
The Journal of Purdue Undergraduate Research
No abstract provided.
Color Transparency From Motions Of Backgrounds And Overlays, Zhehao Huang, Qasim Zaidi
Color Transparency From Motions Of Backgrounds And Overlays, Zhehao Huang, Qasim Zaidi
MODVIS Workshop
No abstract provided.
Computations Of Top-Down Attention By Modulating V1 Dynamics, David Berga, Xavier Otazu
Computations Of Top-Down Attention By Modulating V1 Dynamics, David Berga, Xavier Otazu
MODVIS Workshop
The human visual system processes information defining what is visually conspicuous (saliency) to our perception, guiding eye movements towards certain objects depending on scene context and its feature characteristics. However, attention has been known to be biased by top-down influences (relevance), which define voluntary eye movements driven by goal-directed behavior and memory. We propose a unified model of the visual cortex able to predict, among other effects, top-down visual attention and saccadic eye movements. First, we simulate activations of early mechanisms of the visual system (RGC/LGN), by processing distinct image chromatic opponencies with Gabor-like filters. Second, we use a cortical …
Quantified Measurement Of The Tilt Effect In A Family Of Café Wall Illusions, Nasim Nematzadeh Dr., David Martin Powers Prof.
Quantified Measurement Of The Tilt Effect In A Family Of Café Wall Illusions, Nasim Nematzadeh Dr., David Martin Powers Prof.
MODVIS Workshop
This abstract explores the tilt effect in a family of Café Wall illusions using a Classical Gaussian Receptive Field model (CRF). Our model constructs an intermediate representation called edge map at multiple scales (Fig. 1) that reveals tilt cues and clues involved in the illusory perception of the Café Wall pattern. We investigate a wide range of parameters of the stimulus including mortar width, luminance, tiles contrast, and phase of the tile displacement (the stimuli in Fig. 2). We show that this simple bioplausible model, simulating the contrast sensitivity of the retinal ganglion cells, can not only detect the tilts …