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2010

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Flawed Experimental Design Reveals The Need For Guidelines Requiring Appropriate Positive Controls In Endocrine Disruption Research, F. S. Vom Saal, B. T. Akingbemi, S. M. Belcher, D. A. Crain, D. Crews, L. C. Guidice, P. A. Hunt, J. P. Myers, C. Leranth, A. Nadal, N. Olea, V. Padmanabhan, C. S. Rosenfield, A. Schneyer, G. Schoenfelder, C. Sonnenenschein, A. M. Soto, R. W. Stahlhut, S. H. Swan, L. N. Vandenberg, H. S. Wang, C. S. Watson, W. V. Welshons, R. Thomas Zoeller Jan 2010

Flawed Experimental Design Reveals The Need For Guidelines Requiring Appropriate Positive Controls In Endocrine Disruption Research, F. S. Vom Saal, B. T. Akingbemi, S. M. Belcher, D. A. Crain, D. Crews, L. C. Guidice, P. A. Hunt, J. P. Myers, C. Leranth, A. Nadal, N. Olea, V. Padmanabhan, C. S. Rosenfield, A. Schneyer, G. Schoenfelder, C. Sonnenenschein, A. M. Soto, R. W. Stahlhut, S. H. Swan, L. N. Vandenberg, H. S. Wang, C. S. Watson, W. V. Welshons, R. Thomas Zoeller

R. Thomas Zoeller

A study published in Toxicological Sciences (Ryan et al., 2009) illustrates the importance of examining appropriate doses of both the positive control and the test chemical in research on endocrine-disrupting chemicals. For the three low doses of bisphenol A (BPA) that were fed to rats during pregnancy and lactation, there were no effects on female offspring (there were also no effects on male offspring from the same experiment; Howdeshell et al., 2008). A review of the results of the positive control doses makes it clear that the experiment cannot adequately assess the consequences of low-dose exposure to BPA because the …


Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch Jan 2010

Shearwater Foraging In The Southern Ocean: The Roles Of Prey Availability And Winds, B Raymond, Scott A. Shaffer, S Sokolov, E Woehler, D P. Costa, L Einoder, M Hindell, G Hosie, M Pinkerton, P M. Sagar, D Scott, A Smith, D R. Thompson, C Vertigan, H Weimerskirch

Scott A. Shaffer

Background Sooty (Puffinus griseus) and short-tailed (P. tenuirostris) shearwaters are abundant seabirds that range widely across global oceans. Understanding the foraging ecology of these species in the Southern Ocean is important for monitoring and ecosystem conservation and management. Methodology/Principal Findings Tracking data from sooty and short-tailed shearwaters from three regions of New Zealand and Australia were combined with at-sea observations of shearwaters in the Southern Ocean, physical oceanography, near-surface copepod distributions, pelagic trawl data, and synoptic near-surface winds. Shearwaters from all three regions foraged in the Polar Front zone, and showed particular overlap in the region around 140°E. Short-tailed shearwaters …


Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer Jan 2010

Niche Partitioning Among And Within Sympatric Tropical Seabirds Revealed By Stable Isotope Analysis, H S. Young, D J. Mccauley, R Dirzo, R D. Dunbar, Scott A. Shaffer

Scott A. Shaffer

The low productivity and unpredictable nature of resources in tropical waters would appear to make resource partitioning among predators difficult. Yet, stable isotope data from the present study suggest that substantial resource partitioning occurs among tropical seabird communities, both between and within species. In the present study, we compared δ13C and δ15N levels among 8 sympatric tropical seabird species. For a subset of these species, we also examined isotopic levels across years, breeding periods, and sexes. When breeding and non-breeding periods were both considered, we found that all species occupied distinct isotopic niches across at least one time period. Resource …


Genetic Variation For Susceptibility To Storm-Induced Stem Breakage In Solidago Altissima: The Role Of Stem Height And Morphology, M. Wise, W. Abrahamson Dec 2009

Genetic Variation For Susceptibility To Storm-Induced Stem Breakage In Solidago Altissima: The Role Of Stem Height And Morphology, M. Wise, W. Abrahamson

Warren G. Abrahamson, II

While storms can have obvious ecological impacts on plants, plants’ potential to respond evolutionarily to selection for increased resistance to storm damage has received little study. We took advantage of a thunderstorm with strong wind and hail to examine genetic variation for resistance to stem breakage in the herbaceous perennial Solidago altissima. The storm broke the apex of nearly 10% of 1883 marked ramets in a common-garden plot containing 26 genets of S. altissima. Plant genets varied 20-fold in resistance to breakage. Stem height was strongly correlated with resistance to breakage, with taller stems being significantly more susceptible. A stem’s …


Spatiotemporal Variation Of Fruit Digestible-Nutrient Production In Florida's Uplands, J. Layne, W. Abrahamson Dec 2009

Spatiotemporal Variation Of Fruit Digestible-Nutrient Production In Florida's Uplands, J. Layne, W. Abrahamson

Warren G. Abrahamson, II

We examined annual total digestible nutrient (TDN) production by fruits of eight species (Quercus chapmanii, Q. geminata, Q. inopina, Q. laevis, Q. myrtifolia, Carya floridana, Sabal etonia, Serenoa repens) that account for the major proportion of TDN production by fruits and seeds in Florida’s xeric upland associations (southern ridge sandhill, sand pine scrub, scrubby flatwoods). Mean annual fruit TDN of all species combined over a 27-year span in sandhill and scrub and 24 years in scrubby flatwoods was highest (45.4 kg/ha) in sandhill, intermediate in scrubby flatwoods (28.8 kg/ha), and lowest in scrub (14.2 kg/ha). Sandhill fruit TDN production was …


Dc Expressing Transgene Foxp3 Are Regulatory Apc, Michael Lipscomb Dec 2009

Dc Expressing Transgene Foxp3 Are Regulatory Apc, Michael Lipscomb

Michael Lipscomb

Tolerogenic DC and suppressive Foxp3(+) Treg play important roles in preventing autoimmunity and allograft rejection. We report that (adenovirus mediated) ectopic expression of Foxp3 in human DC (i.e. DC.Foxp3) yields an APC that severely limits T-cell proliferation and type-1 immune responses from the naïve, but not memory, pool of responder T cells in vitro. In marked contrast, the frequencies of type-2 and Treg responses were dramatically increased after stimulation of naïve T cells with DC.Foxp3 versus control DC. DC.Foxp3-induced CD4(+)CD25(+) Treg cells potently suppressed the proliferation of, and IFN-gamma production from, CD4(+) and CD8(+) responder T cells. Notably, the immunosuppressive …


Nomenclatural Changes For Some Grasses In California And The Muhlenbergia Clade (Poaceae), James Payne Smith Jr. Dec 2009

Nomenclatural Changes For Some Grasses In California And The Muhlenbergia Clade (Poaceae), James Payne Smith Jr.

James Payne Smith

No abstract provided.


3hsds1和17hsds7基因5'上游区转录活性研究.Pdf, Xinxing Dong, Yi Xin, Ying Bai, Yunzhou Yang, Jibin Zhang, Meiying Fang, Gang Chen Dec 2009

3hsds1和17hsds7基因5'上游区转录活性研究.Pdf, Xinxing Dong, Yi Xin, Ying Bai, Yunzhou Yang, Jibin Zhang, Meiying Fang, Gang Chen

Jibin Zhang

3β-hydroxysteroid dehydrogenases (HSDs) and 17βHSDs are pivotal enzymes involved in synthesis, activation and deactivation of steroid hormones. Therefore, they play an important role to maintain homeostasis of hormone and regulate the synthesis and metabolism of hormones, and they are also related to metabolism of androstenone which can cause boar taint in male pigs. Through ligation of different PCR fragments of these genes from Large White pigs to pGL3-basic plasmid and subsequent transient transfection of constructed vectors into HepG2 cell culture, we found that the fragment from -1038bp to 45bp in porcine 3βHSD gene and the fragment from -966bp to 39bp …


Ducking As The Means Of Resistance In "Candy-Cane" Stems Of Goldenrod: Straightened Stems Lose Their Edge, M. J. Wise, W. G. Abrahamson, J. A. Cole Dec 2009

Ducking As The Means Of Resistance In "Candy-Cane" Stems Of Goldenrod: Straightened Stems Lose Their Edge, M. J. Wise, W. G. Abrahamson, J. A. Cole

Warren G. Abrahamson, II

Herbivores are among the most pervasive selective forces acting on plants, and the number of plant chemicals that presumably evolved for defense against herbivory is immense. In contrast, biologists are only beginning to appreciate the important roles that architectural traits can play in antiherbivore defense. One putative architectural-resistance trait is the nodding stem apex of some goldenrods (Solidago ; Asteraceae). Individuals of S. altissima genets that undergo temporary nodding in the late spring (i.e., “candy-cane ramets) have been shown to be more resistant than individuals of erect-stemmed genets to certain apex-attacking” herbivores. We tested the hypothesis that the greater resistance …


Nutrition As A Facilitator Of Host-Race Formation: The Role Of Food Quality In The Shift Of A Stem-Boring Beetle To A Gall Host, C. P. Blair, R. V. Schlanger, S. E. Diamond, W. G. Abrahamson Dec 2009

Nutrition As A Facilitator Of Host-Race Formation: The Role Of Food Quality In The Shift Of A Stem-Boring Beetle To A Gall Host, C. P. Blair, R. V. Schlanger, S. E. Diamond, W. G. Abrahamson

Warren G. Abrahamson, II

1. The importance of host-race formation to herbivorous insect diversity depends on the likelihood that successful populations can be established on a new plant host. A previously unexplored ecological aid to success on a novel host is better nutritional quality. The role of nutrition was examined in the shift of the stem-boring beetle Mordellistena convicta to fly-induced galls on goldenrod and the establishment there of a genetically distinct gall host race. 2. First, larvae of the host race inhabiting stems of Solidago gigantea were transplanted into stems and galls of greenhouse-grown S. gigantea plants. At the end of larval development, …


Children In Jeopardy: Anthropogenic Toxins And Childhood Exposure, Russell Butkus, Steve Kolmes Dec 2009

Children In Jeopardy: Anthropogenic Toxins And Childhood Exposure, Russell Butkus, Steve Kolmes

Steve Kolmes

No abstract provided.


Polyphyly Of The Pikeminnows (Teleostei: Cyprinidae) Inferred Using Mitochondrial Dna Sequences, T. Heath Ogden Dec 2009

Polyphyly Of The Pikeminnows (Teleostei: Cyprinidae) Inferred Using Mitochondrial Dna Sequences, T. Heath Ogden

T. Heath Ogden

The phylogenetic relationships of the Colorado pikeminnow Ptychocheilus lucius, northern pikeminnow P. oregonensis, Sacramento pikeminnow P. grandis, Umpqua pikeminnow P. umpquae, and hardhead Mylopharodon conocephalus were examined by using molecular data to investigate monophyly of the genus Ptychocheilus. Phylogenies generated using DNA sequence data from the cytochrome b and 16S ribosomal DNA genes of the mitochondrial genome reveal that Ptychocheilus is a polyphyletic genus and suggest that the taxonomy of the group is in need of further revision. These data yield insights into the evolution of the pikeminnows and help place the significant evolutionary events in context with the geological …