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Biomimetic Macromolecules For Macrophage Targeting And Modulation, Joshua Whited
Biomimetic Macromolecules For Macrophage Targeting And Modulation, Joshua Whited
ETD Archive
Carbohydrate recognition has come to the forefront of biological aiming to uncover the mechanisms of physiological and pathological processes. Cell surface glycans are involved in processes including cellular adhesion, cell signaling, and immune response. A new approach for profiling cell surface glycans has great potential for a wide range of biomedical applications. Lectins have been conventionally used to determine the structure and function of glycoproteins, however, their numbers are still restricted compared to the number of glycan structures. Boronic acid has proven a remarkable small molecule capable of binding diols in aqueous solution. This interaction indicates boronic acid derived molecules …
A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr.
A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr.
ETD Archive
Star polymers are a class of branched polymers comprised of several polymer chains extending from a central point. Star polymers have applications in biopharmaceuticals where they have been proposed to be suitable drug delivery vehicles. Star polymers have traditionally been synthesized through chemical synthesis with added functionality provided by grafting on the arms. This complex synthesis can be simplified by using a biosynthetic approach which enables precise control of molecular weight and composition. This approach is demonstrated using star polymers with arms composed of a temperature responsive protein-based polymer termed elastin-like polypeptide (ELP). Star polymers are characterized based on the …
The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh
The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh
ETD Archive
INTRODUCTION The Naked Mole Rat [ Heterocephalus glaber] is a type of rodent -with the highest average lifespan-30 years-among all the rodent species. It lives underground in sealed burrow systems with little to no exposure to day-night transitions on the surface. It shows polyphasic round the clock activity within its subterranean burrow system. The activity and physiology of most animals are governed by the biological circadian clock. The biological circadian clock is a system that oscillates with a rough periodicity of 24 hours. Environmental zeitgebers regulate the entrainment of the circadian clock to the 24-hour day-night cycle and light is …