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Multi-Component Perfusion Chromatography In Fixed Bed And Periodic Counter Current Column Operation, G. A. Heeter, Athanasios I. Liapis
Multi-Component Perfusion Chromatography In Fixed Bed And Periodic Counter Current Column Operation, G. A. Heeter, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A mathematical model of multi-component dynamic adsorption in columns with spherical perfusive and spherical purely diffusive adsorbent particles with a bidisperse porous structure is constructed, solved, and used to study the performance of a binary adsorption system in a single-column fixed-bed process and in a two-column periodic countercurrent process in which the adsorbent is equally distributed over two beds. The total length of the two-column periodic counter-current system is equal to the length of the single-column fixed-bed system. The performance of fixed-bed and periodic counter-current systems with both perfusive and purely diffusive adsorbent particles is examined for different values of …
Modelling And Analysis Of The Elution Stage Of "Perfusion Chromatography" Effects Of Intraparticle Convective Velocity And Microsphere Size On System Performance, Y. Xu, Athanasios I. Liapis
Modelling And Analysis Of The Elution Stage Of "Perfusion Chromatography" Effects Of Intraparticle Convective Velocity And Microsphere Size On System Performance, Y. Xu, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A mathematical model describing the dynamic elution (elution stage) in columns with spherical bidisperse perfusive or spherical bidisperse purely diffusive adsorbent particles is presented and its solution is obtained numerically. The desorption of bovine serum albumin (BSA) from spherical anion-exchange porous particles was studied for different values of the intraparticle Peclet numbers of the adsorbate, (Peintra)a, and eluent, (Peintra)e, and of the microsphere diameter, dm. It was found that as (Peintra)a increases, the asymmetry of the elution peak of the adsorbate (at the exit of the column) decreases, the peak height increases and the time, Te, required for the elution …