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Network Modeling Of The Intraparticle Convection And Diffusion Of Molecules In Porous Particles Packed In A Chromatographic Column, J. J. Meyers, Athanasios I. Liapis
Network Modeling Of The Intraparticle Convection And Diffusion Of Molecules In Porous Particles Packed In A Chromatographic Column, J. J. Meyers, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A pore network model (cubic lattice network) is constructed to represent the porous structure in a column packed with porous chromatographic particles. Expressions are developed and used to determine, through the utilization of the pore network model, the intraparticle interstitial fluid velocity and pore diffusivity of a solute as the pore connectivity, n(T), of the porous medium is varied from 2.6 to 6.0. The results show that the intraparticle interstitial velocity and the pore diffusivity increase significantly as the value of the pore connectivity, n(T), increases, and clearly indicate that the pore connectivity, n(T), plays a key role in determining …
Estimation Of Pore Diameter For Intraparticle Fluid Flow In Hidisperse Porous Chromatographic Particles, G. A. Heeter, Athanasios I. Liapis
Estimation Of Pore Diameter For Intraparticle Fluid Flow In Hidisperse Porous Chromatographic Particles, G. A. Heeter, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A quantitative method is developed and presented for estimating the mean pore diameter, d(pore), that could allow intraparticle fluid flow in the macroporous region of adsorbent particles with a bidisperse porous structure packed in a column. The method is used to estimate the value of d(pore) that is required to obtain specified values of the fraction, F, of the column superficial fluid velocity that is flowing through the macroporous region of the adsorbent particles and the value of d(pore) that is required to obtain specified values of the intraparticle Peclet number, Pe(intra).
Multi-Component Perfusion Chromatography In Fixed Bed And Periodic Counter Current Column Operation, G. A. Heeter, Athanasios I. Liapis
Multi-Component Perfusion Chromatography In Fixed Bed And Periodic Counter Current Column Operation, G. A. Heeter, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A mathematical model of multi-component dynamic adsorption in columns with spherical perfusive and spherical purely diffusive adsorbent particles with a bidisperse porous structure is constructed, solved, and used to study the performance of a binary adsorption system in a single-column fixed-bed process and in a two-column periodic countercurrent process in which the adsorbent is equally distributed over two beds. The total length of the two-column periodic counter-current system is equal to the length of the single-column fixed-bed system. The performance of fixed-bed and periodic counter-current systems with both perfusive and purely diffusive adsorbent particles is examined for different values of …
Modelling And Analysis Of The Elution Stage Of "Perfusion Chromatography" Effects Of Intraparticle Convective Velocity And Microsphere Size On System Performance, Y. Xu, Athanasios I. Liapis
Modelling And Analysis Of The Elution Stage Of "Perfusion Chromatography" Effects Of Intraparticle Convective Velocity And Microsphere Size On System Performance, Y. Xu, Athanasios I. Liapis
Chemical and Biochemical Engineering Faculty Research & Creative Works
A mathematical model describing the dynamic elution (elution stage) in columns with spherical bidisperse perfusive or spherical bidisperse purely diffusive adsorbent particles is presented and its solution is obtained numerically. The desorption of bovine serum albumin (BSA) from spherical anion-exchange porous particles was studied for different values of the intraparticle Peclet numbers of the adsorbate, (Peintra)a, and eluent, (Peintra)e, and of the microsphere diameter, dm. It was found that as (Peintra)a increases, the asymmetry of the elution peak of the adsorbate (at the exit of the column) decreases, the peak height increases and the time, Te, required for the elution …