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Roles Of Dietary Bioactive Compounds In Gut Microbiota Modulation And Epigenetic Regulation In The Prevention Of Breast Cancer, Huixin Wu
All ETDs from UAB
Breast cancer (BC) is the second most common cancer and the second leading cause of cancer death among women in the United States. The average risk of a woman developing BC is about 13% according to American Cancer Society. Various genetic-related risk factors including inherited mutations of genes, and lifestyle-related risk factors such as physical inactivity, obesity, aging, smoking, and air pollution have been studied for cancer prevention and treatment. The currently existing treatment methods such as chemotherapy and neoadjuvant systemic therapy can induce adverse effects on patients. Therefore, cancer prevention has been of great interest to the society. Numerous …
The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora
The Potential Roles Of Broccoli Sprouts (Bsp) And Green Tea Polyphenols (Gtps) In Prevention Of Mammary Cancer, Itika Arora
All ETDs from UAB
Cancer is one of the leading causes of death in the United States. Based on the American Cancer Society statistics, in 2021 1,806,590 new cancer cases and 605,520 cancer deaths are projected to occur in the United States. Amongst all, breast cancer (BC) is one of the most prevalent cancers that occurs in women. Various lifestyle factors such as alcohol intake, smoking, an unhealthy diet and physical inactivity may result in increased rates of BC risks (cancer-transition) by inducing mutations in DNA. Numerous epidemiological studies indicate that a diet rich in green tea polyphenols (GTPs), and/or cruciferous vegetables such as …
Role Of Dietary Compounds On Modulation Of Epigenetic Mechanisms And Gut Microbiota In Prevention Of Breast Cancer, Manvi Sharma
Role Of Dietary Compounds On Modulation Of Epigenetic Mechanisms And Gut Microbiota In Prevention Of Breast Cancer, Manvi Sharma
All ETDs from UAB
Breast cancer is the second leading causes of mortality among women living in the United States, representing a major public health issue. The current chemoprevention therapies can result into various adverse effects. Therefore, the use of dietary bioactive compounds has been of great interest due to their safer, non-toxic and efficacious properties. Sulforaphane (SFN) is an isothiocyanate found in various cruciferous vegetables such as broccoli sprouts (BSp) and green-tea polyphenols (GTPs) contain a major polyphenol, (-)-epigallocatechin-3-gallate (EGCG). These compounds have been shown to exhibit several anticancer properties especially as an epigenetic modifier. We investigated the efficacy of BSp or GTPs …
Genome-Wide Mirna Regulation Of Stress Susceptibility Across The Brain In A Rodent Model Of Early Life Stress, Lauren Alexis Allen Mckibben
Genome-Wide Mirna Regulation Of Stress Susceptibility Across The Brain In A Rodent Model Of Early Life Stress, Lauren Alexis Allen Mckibben
All ETDs from UAB
Early life stress (ELS) affects a significant portion of the US population in the form of various types of abuse and neglect, as well as household dysfunction and loss of a loved one, among others. Although these experiences happen early in life, they increase risk for mental health disorders, especially major depression (MDD), across the lifespan. MDD is a debilitating psychiatric disorder marked by periods of depressed mood and loss of pleasure in once enjoyable activities. Patients with MDD also report trouble sleeping, unintentional weight loss or gain, feelings of worthlessness, and suicidal ideation. MDD is associated with annual $100 …
The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed
The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed
All ETDs from UAB
About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …
Effect Of Dietary Compounds In Epigenetic Modulation And Microbial Alteration And Their Roles In Breast Tumor Inhibition, Bidisha Paul
Effect Of Dietary Compounds In Epigenetic Modulation And Microbial Alteration And Their Roles In Breast Tumor Inhibition, Bidisha Paul
All ETDs from UAB
Breast cancer is a major cause of cancer death among women in the United States. Current methods of chemoprevention and therapy have cytotoxic effects and have several short-term and long-term side effects. Therefore, the use of natural dietary bioactive compounds has gained prominence as safe and effective agents of chemoprevention and therapy. Genistein (GE), an isoflavone found in soy products, has been shown to exhibit several anticancer properties, particularly as an epigenetic modifier. We have observed that GE has the ability to alter the gut microbiome of germ-free mice humanized with fecal transplants from breast cancer patients undergoing chemotherapy. We …
Combinatorial Withaferin A And Sulforaphane And Their Potential Roles In Breast Cancer Prevention And Therapy, Kendra Jeanine Royston
Combinatorial Withaferin A And Sulforaphane And Their Potential Roles In Breast Cancer Prevention And Therapy, Kendra Jeanine Royston
All ETDs from UAB
Cancer is a leading cause of death worldwide and is a devastating disease. Breast cancer is of particular interest because it is a major cause of cancer-related fatality in women in the United States. To date, more than 40,000 women are expected to die due to breast cancer and more than 200,000 will be diagnosed every year. Despite numerous advancements in the field, breast cancer remedies can be harsh and while life may be prolonged, the quality of life may decrease. This being said, preventive measures and less harsh treatment options are needed to help eliminate breast cancer as a …
Effects Of Proanthocyanidins In Combination With Resveratrol And Sulforaphane Respectively On Human Breast Cancer Cells, Yifeng Gao
All ETDs from UAB
Breast cancer is the second most common cancer and the second leading cause of death from cancer among women in the United States. Cancer prevention and therapy through use of phytochemicals that have epigenetic properties has gained considerable popularity during the past few decades. Such dietary components include but are not limited to grape seed proanthocyanidins (GSPs), resveratrol (Res) and sulforaphane (SFN). Here we report for the first time that GSPs and Res in combination dose- and time-dependently inhibited cell viability and posttreatment colony forming ability synergistically in MDA-MB-231 and MCF-7 human breast cancer cells, while GSPs and SFN in …
A Multi-Modal Approach To Sulforaphane-Mediated Chemoprevention Using The Epigenetic Network, Samantha Martin
A Multi-Modal Approach To Sulforaphane-Mediated Chemoprevention Using The Epigenetic Network, Samantha Martin
All ETDs from UAB
Colon cancer is the third most common diagnosed cancer in both women and men in the United States. It is reported that dietary factors are responsible for 70-90% of colon cancer cases. While some investigators have observed a direct correlation in high fat diets and cancer initiation, other studies have observed opposite effects mediated by fruit and vegetable consumption. Recently, studies have highlighted the importance of Epigenetics as it modifies gene expression without changing the DNA sequence. Notably, several nutritive compounds have been reported to alter epigenetic profiles in many cancer forms. SFN, an isothiocyanate found in cruciferous vegetables such …
Genetic And Epigenetic Changes Regulated By Bioactive Molecules In Cancer Therapeutics, Sabita Saldanha
Genetic And Epigenetic Changes Regulated By Bioactive Molecules In Cancer Therapeutics, Sabita Saldanha
All ETDs from UAB
Cancer biogenesis stems from genetic and epigenetic changes that regulate various signaling pathways responsible for growth, division, and proliferation. Genetic changes occur through mutations that contribute to loss of function, overexpression or repression of proteins involved in metabolic pathways. The changes place individuals at risk to diseases, including cancer. However, epigenetics is a mechanism of gene control that occurs through changes in chromatin structure without alterations to the DNA sequence and is mostly reversible. Epigenetic alterations have been implicated in colorectal cancers (CRCs), transforming normal colonic epithelial cells. Aberrant DNA methylation and chromatin modifications have been shown to contribute to …
Epigenetic Regulation Of Hippocampus-Dependent Learning, Laura Qadri
Epigenetic Regulation Of Hippocampus-Dependent Learning, Laura Qadri
All ETDs from UAB
Knowledge of the molecular mechanisms that underlie learning and memory has advanced a great deal. Research into the role of epigenetics, or modifications above the genome, has the promise of providing an even greater understanding of the precise mechanisms involved in memory formation. Studies of epigenetic regulation of memory in the rodent hippocampus have primarily focused on associative learning using contextual fear conditioning. While these studies have provided valuable insight into the role that epigenetics plays in cognition, it remains to be seen whether the findings generalize to other forms of hippocampus-dependent learning. This work examines the role of epigenetic …
Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell
Genome-Wide Dna Methylation Changes During Breast Tumorigenesis, Natalie E. Mitchell
All ETDs from UAB
Neoplastic reprogramming generates cancerous cells from normal derivatives, enabling researchers to create a model of the early stages of oncogenesis and analyze molecular changes in real-time. Aberrations in DNA methylation are considered a major mechanism contributing to the acquisition and maintenance of a cancerous phenotype; however, little research exists regarding gene-specific changes in DNA methylation during the transition from a normal to neoplastic cell. Human mammary epithelial cells (HMECs) underwent neoplastic transformation through the addition of three defined genetic elements to generate one line of semi-transformed, pre-malignant cells (SHMECs) and two separate lines of fully transformed, malignant cells (THMECs). We …
Reactivation Of Estrogen Receptor-Α (Erα) By Bioactive Dietary Compounds Through Epigenetic Mechanisms In Erα-Negative Breast Cancer Cells, Shweta Naran Patel
Reactivation Of Estrogen Receptor-Α (Erα) By Bioactive Dietary Compounds Through Epigenetic Mechanisms In Erα-Negative Breast Cancer Cells, Shweta Naran Patel
All ETDs from UAB
In breast cancer treatment, the presence of the estrogen receptor-alpha (ERα) plays an important role with hormonal-responsive drugs such as tamoxifen. ERα-negative breast cancers are more aggressive not only because of the increased uncontrollable growth but also because of the lack of target-directed treatments. Bioactive dietary components such as green tea polyphenols (GTPs) and sulforaphane (SFN, found in cruciferous vegetables) have been shown to have anti-cancer properties. In this study, we found that the dietary combination of a DNA methyltransferases (DNMTs) inhibitor, GTPs, and a histone deacetylase (HDAC) inhibitor, SFN, dose-dependently inhibited the proliferation of ERα-negative MDA-MB-231 human breast cancer …
An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson De Angelis
An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson De Angelis
All ETDs from UAB
Cell culture models of oncogenesis that use cellular reprogramming to generate a neoplastic cell from a normal cell provide one of the few opportunities to study the early stages of breast cancer development. Human mammary epithelial cells (HMECs) were induced to undergo a neoplastic transformation using defined genetic elements to generate transformed HMECs (THMECs). We conducted proteomic and transcriptomic analysis of three points in the neoplastic progression of breast cancer. First we monitored alterations in the proteome that revealed a progressive trend towards a metastatic state. Next, we identified a set of genes from transcriptomic analysis that displayed this same …