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University of Alabama at Birmingham

Theses/Dissertations

2019

Epigenetics

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The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed Jan 2019

The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed

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About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …