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Mechanistic Plug-And-Play Models For Understanding The Impact Of Control And Climate On Seasonal Dengue Dynamics In Iquitos, Peru, Nathan Levick

Mathematics & Statistics ETDs

Dengue virus is a mosquito-borne multi-serotype disease whose dynamics are not precisely understood despite half of the world’s human population being at risk of infection. A recent dataset of dengue case reports from an isolated Amazonian city— Iquitos, Peru—provides a unique opportunity to assess dengue dynamics in a simpli- fied setting. Ten years of clinical surveillance data reveal a specific pattern: two novel serotypes, in turn, invaded and exclusively dominated incidence over several seasonal cycles, despite limited intra-annual variation in climate conditions. Together with mechanistic mathematical models, these data can provide an improved understand- ing of the nonlinear interactions between …

Microstructural Analysis Of Thermoelastic Response, Nonlinear Creep, And Pervasive Cracking In Heterogeneous Materials, Alden C. Cook

Electronic Theses and Dissertations

This dissertation is concerned with the development of robust numerical solution procedures for the generalized micromechanical analysis of linear and nonlinear constitutive behavior in heterogeneous materials. Although the methods developed are applicable in many engineering, geological, and materials science fields, three main areas are explored in this work. First, a numerical methodology is presented for the thermomechanical analysis of heterogeneous materials with a special focus on real polycrystalline microstructures obtained using electron backscatter diffraction techniques. Asymptotic expansion homogenization and finite element analysis are employed for micromechanical analysis of polycrystalline materials. Effective thermoelastic properties of polycrystalline materials are determined and compared …

Mathematical Analysis Of Feedback Targets Of Bmp Signaling In Drosophila Embryonic Development, Yan Luo

Open Access Theses

Bone morphogenetic proteins (BMPs) drive a range of cellular processes especially in the early stages of embryonic development. This family of proteins acts as one of the most important extracellular signals in development pattern formation across the animal kingdom. Cells in embryos differentiate into different cell types in response to the concentration level of BMP. This complex process is regulated by multiple regulators that serve to tune the signal response.

Extensive experimental and computational research has been performed to analyze BMP regulation in Drosophila, a widely studied model organism, and has advanced our understanding of animal development. Because of …

On The Propagation Of Atmospheric Gravity Waves In A Non-Uniform Wind Field: Introducing A Modified Acoustic-Gravity Wave Equation, Ahmad Talaei

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Atmospheric gravity waves play fundamental roles in a broad-range of dynamical processes extending throughout the Earth’s neutral atmosphere and ionosphere. In this paper, we present a modified form for the acoustic-gravity wave equation and its dispersion relationships for a compressible and non-stationary atmosphere in hydrostatic balance. Importantly, the solutions have been achieved without the use of the well-known Boussinesq approximation which have been used extensively in previous studies.

We utilize the complete set of governing equations for a compressible atmosphere with non-uniform airflows to determine an equation for vertical velocity of possible atmospheric waves. This intricate wave equation is simplified …

Density Estimation For Lifetime Distributions Under Semi-Parametric Random Censorship Models, Carsten Harlass

Theses and Dissertations

We derive product limit estimators of survival times and failure rates for randomly right censored data as the numerical solution of identifying Volterra integral equations by employing explicit and implicit Euler schemes. While the first approach results in some known estimators, the latter leads to a new general type of product limit estimator. Plugging in established methods to approximate the conditional probability of the censoring indicator given the observation, we introduce new semi-parametric and presmoothed Kaplan-Meier type estimators. In the case of the semi-parametric random censorship model, i.e. the latter probability belonging to some parametric family, we study the strong …

Modern Fair-Weather And Storm Sediment Transport Around Ship Island, Mississippi: Implications For Coastal Habitats And Restoration Efforts, Eve Rettew Eisemann

Master's Theses

The Mississippi – Alabama barrier island chain is experiencing accelerated sea level rise, decreased sediment supply, and frequent hurricane impacts. These three factors drive unprecedented rates of morphology change and ecosystem reduction. All islands in the chain have experienced land loss on the order of hectares per year since records began in the 1840s. In 1969, Hurricane Camille impacted as a Category 5, breaching Ship Island, and significantly reduced viable seagrass habitat. Hurricane Katrina impacted as a Category 3 in 2005, further widening Camille Cut. To better understand the sustainability of these important islands and the ecosystems they support, sediment …

A Traders Guide To The Predictive Universe- A Model For Predicting Oil Price Targets And Trading On Them, Jimmie Harold Lenz

Doctor of Business Administration Dissertations

At heart every trader loves volatility; this is where return on investment comes from, this is what drives the proverbial “positive alpha.” As a trader, understanding the probabilities related to the volatility of prices is key, however if you could also predict future prices with reliability the world would be your oyster. To this end, I have achieved three goals with this dissertation, to develop a model to predict future short term prices (direction and magnitude), to effectively test this by generating consistent profits utilizing a trading model developed for this purpose, and to write a paper that anyone with …

Spreading Speeds Along Shifting Resource Gradients In Reaction-Diffusion Models And Lattice Differential Equations., Jin Shang

Electronic Theses and Dissertations

A reaction-diffusion model and a lattice differential equation are introduced to describe the persistence and spread of a species along a shifting habitat gradient. The species is assumed to grow everywhere in space and its growth rate is assumed to be monotone and positive along the habitat region. We show that the persistence and spreading dynamics of a species are dependent on the speed of the shifting edge of the favorable habitat, c, as well as c^*(∞) and c^*(−∞), which are formulated in terms of the dispersal kernel and species growth rates in both directions. When …

Fast Method Of Particular Solutions For Solving Partial Differential Equations, Anup Raja Lamichhane

Dissertations

Method of particular solutions (MPS) has been implemented in many science and engineering problems but obtaining the closed-form particular solutions, the selection of the good shape parameter for various radial basis functions (RBFs) and simulation of the large-scale problems are some of the challenges which need to overcome. In this dissertation, we have used several techniques to overcome such challenges.

The closed-form particular solutions for the Matérn and Gaussian RBFs were not known yet. With the help of the symbolic computational tools, we have derived the closed-form particular solutions of the Matérn and Gaussian RBFs for the Laplace and biharmonic …

Preliminary Investigation For The Development Of Surrogate Debris From Nuclear Detonations In Marine-Urban Environments, Adam G. Seybert

Masters Theses

No nuclear weapon has ever been detonated in a United States city. However, this also means the nuclear forensic community has no actual debris from which to develop analytical methods for source attribution, making the development of surrogate nuclear debris a vital undertaking. Moreover, the development of marine-urban debris presents an unusual challenge because unlike soil and urban structures, which remain compositionally consistent, the elemental composition of harbor and port waters fluctuates considerably due to natural phenomenon and human activity. Additionally, marine vessel composition and cargo can vary dramatically. While early US nuclear tests were carried out in shallow-water coastal …

Network Inference Driven Drug Discovery, Gergely Zahoránszky-Kőhalmi, Tudor I. Oprea Md, Phd, Cristian G. Bologa Phd, Subramani Mani Md, Phd, Oleg Ursu Phd

Biomedical Sciences ETDs

The application of rational drug design principles in the era of network-pharmacology requires the investigation of drug-target and target-target interactions in order to design new drugs. The presented research was aimed at developing novel computational methods that enable the efficient analysis of complex biomedical data and to promote the hypothesis generation in the context of translational research. The three chapters of the Dissertation relate to various segments of drug discovery and development process.

The first chapter introduces the integrated predictive drug discovery platform „SmartGraph”. The novel collaborative-filtering based algorithm „Target Based Recommender (TBR)” was developed in the framework of this …

Studies On Lattice Systems Motivated By Pt-Symmetry And Granular Crystals, Haitao Xu

Doctoral Dissertations

This dissertation aims to study some nonlinear lattice dynamical systems arising in various areas, especially in nonlinear optics and in granular crystals. At first, we study the 2-dimensional PT-symmetric square lattices (of the discrete non-linear Schr¨odinger (dNLS) type) and identify the existence, stability and dynamical evolu- tion of stationary states, including discrete solitons and vortex configurations. To enable the analytical study, we consider the so-called anti-continuum (AC) limit of lattices with uncoupled sites and apply the Lyapunov–Schmidt reduction. Numerical experiments will also be provided accordingly. Secondly, we investigate the nonlinear waves in the granular chains of elastically inter- acting (through …

Computation Of Real Radical Ideals By Semidefinite Programming And Iterative Methods, Fei Wang

Electronic Thesis and Dissertation Repository

Systems of polynomial equations with approximate real coefficients arise frequently as models in applications in science and engineering. In the case of a system with finitely many real solutions (the $0$ dimensional case), an equivalent system generates the so-called real radical ideal of the system. In this case the equivalent real radical system has only real (i.e., no non-real) roots and no multiple roots. Such systems have obvious advantages in applications, including not having to deal with a potentially large number of non-physical complex roots, or with the ill-conditioning associated with roots with multiplicity. There is a corresponding, but more …

Generalized Partial Directed Coherence And Centrality Measures In Brain Networks For Epileptogenic Focus Localization, Joshua Aaron Adkinson

Doctoral Dissertations

Accurate epileptogenic focus localization is required prior to surgical resection of brain tissue for treatment of patients with intractable temporal lobe epilepsy, a clinical need that is partially fulfilled to date through a subjective, and at times inconclusive, evaluation of the recorded electroencephalogram (EEG). Using brain connectivity analysis, patterns of causal interactions between brain regions were derived from multichannel EEG of 127 seizures in nine patients with focal, temporal lobe epilepsy (TLE). The statistically significant directed interactions in the reconstructed brain networks were estimated from three second intracranial multi-electrode EEG segments using the Generalized Partial Directed Coherence (GPDC) and validated …

Performance-Robust Dynamic Feedback Control Of Lipschitz Nonlinear Systems, Winston Baker

Dissertations (1934 -)

This dissertation addresses the dynamic control of nonlinear systems with finite energy noise in the state and measurement equations. Regional eigenvalue assignment (REA) is used to ensure that the state estimate error is driven to zero significantly faster than the state itself. Moreover, the controller is designed for the resulting closed loop system to achieve any one of a set of general performance criteria (GPC). The nonlinear model is assumed to have a Lipschitz nonlinearity both in the state and measurement equations. By using the norm bound of the nonlinearity, the controller is designed to be robust against all nonlinearities …

Essays In Market Structure And Liquidity, Adrian J. Walton

Electronic Thesis and Dissertation Repository

Market structure concerns the mechanisms for negotiating trades and the composition of trading participants, and can affect liquidity and price efficiency. More gains from trade can be realized from an asset that is more liquid, and a better allocation of risk and capital can be achieved when an asset’s price is more efficient so it is important to understand market structure. This thesis uses theory and empirical methods to examine the effects of a few specific aspects of market structure.

In Chapter 1, we study a novel market structure on the New York Stock Exchange (NYSE), the Retail Liqudity Program …

Time Domain Analysis Of Electromagnetic Scattering From Multiple Cavities Embedded In A Ground Plane, Richard P. Uber

Theses and Dissertations

This work examines the scattered fields produced when a transient wave is reflected from an infinite perfect electric conductor (PEC) ground plane with multiple embedded cavities. Incident and reflected waves will be decomposed into transverse magnetic to the z direction (TMz) and transverse electric to the z direction (TEz) polarizations, with primary focus given to the TMz. Cavities may be unfilled, partially filled, or fully filled with non-magnetic dielectric material and no assumptions are made regarding similarity, regularity, or periodicity. The Newmark method is used to discretize time and a variational formulation is presented for each time step. The principle …

Synergistic Effects Of Phase Folding And Wavelet Denoising With Applications In Light Curve Analysis, Andrew M. Armstrong

Theses and Dissertations

The growing size of cosmological data sets is causing the current human-centric approach to cosmology to become impractical. Autonomous data analysis techniques need to be developed in order to advance the field of cosmology. This research examines the benefits of combining two signal analysis techniques, namely phase folding and wavelet denoising, into a newly-developed suite of autonomous light curve analysis tools which includes aspects of component extraction and period detection. The improvements these tools provide, with respect to autonomy and signal quality, are demonstrated using both simulated and real-world light curve data. Although applied to light curve data, the suite …

Takagi-Sugeno Fuzzy Model Based Discrete Time Model Predictive Control For A Hypersonic Re-Entry Vehicle, Ben Margolis

Applied Mathematics Master's Theses

In this thesis, we present a control algorithm for a hypersonic re-entry vehicle during a Martian aerocapture maneuver. The proposed algorithm utilizes a discrete-time model predictive control technique with a Takagi-Sugeno fuzzy model of the vehicle to control the re-entry vehicle along an arbitrary trajectory using bank angle modulation. Simulations using model parameters and initial conditions from a Martian aerocapture mission demonstrate the stability, performance, and robustness of the proposed controller.

Studying Both Direct And Indirect Effects In Predator-Prey Interaction, Xiaoying Wang

Electronic Thesis and Dissertation Repository

Studying and modelling the interaction between predators and prey have been one of the central topics in ecology and evolutionary biology. In this thesis, we study two different aspects of predator-prey interaction: direct effect and indirect effect.

Firstly, we study the direct predation between predators and prey in a patchy landscape.

Secondly, we study indirect effects between predators and prey.

Thirdly, we extend our previous model by incorporating a stage-structure into prey.

Finally, we further extend our previous model by incorporating spatial structures into modelling.

A Comparison Of Solution Methods For Mandelbrot-Like Polynomials, Eunice Y. S. Chan

Electronic Thesis and Dissertation Repository

We compare two different root-finding methods, eigenvalue methods and homotopy methods, using three test problems: Mandelbrot polynomials, Fibonacci-Mandelbrot polynomials, and Narayana-Mandelbrot polynomials. For the eigenvalue methods, using both MATLAB and Maple, we computed the eigenvalues of a specialized recursively-constructed, supersparse, upper Hessenberg matrix, inspired by Piers Lawrence's original construction for the Mandelbrot polynomials, for all three families of polynomials. This led us to prove that this construction works in general. Therefore, this construction is genuinely a new kind of companion matrix. For the homotopy methods, we used a special-purpose homotopy, in which we used an equivalent differential equation to solve …

Bacteria-Phage Models With A Focus On Prophage As A Genetic Reservoir, Alina Nadeem

Electronic Thesis and Dissertation Repository

Temperate bacteriophages have the ability to incorporate their genetic material in the host's DNA, which may be utilized by later generations of phage to overcome the host's receptor-based defences. This effect of temperance can have major implications for the long-term survival of the phages as well as on bacteria-phage community evolution. To study the impact of prophage on microbial communities we have developed models simulating lytic and lysogenic infection and host and phage coevolution with a focus on prophage-phage recombination. Our results show that recombination can be crucial for the phage to survive host diversification, and a higher incidence of …

Modeling The Mass Function Of Stellar Clusters Using The Modified Lognormal Power-Law Probability Distribution Function, Deepakshi Madaan

Electronic Thesis and Dissertation Repository

We use the Modified Lognormal Power-law (MLP) probability distribution function to model the behaviour of the mass function (MF) of young and populous stellar populations in different environments. We begin by modeling the MF of NGC1711, a simple stellar population (SSP) in the Large Magellanic Cloud as a pilot case. We then use model selection criterion to differentiate between candidate models. Using the MLP we find that the stellar catalogue of NGC1711 follows a pure power-law behaviour below the completeness limit with the slope α = 2.75 for dN/dlnm ∝ m^(−α+1) in the mass range 0.89 M⊙ to 7.75 M⊙. …

Newsvendor Models With Monte Carlo Sampling, Ijeoma W. Ekwegh

Electronic Theses and Dissertations

Newsvendor Models with Monte Carlo Sampling by Ijeoma Winifred Ekwegh The newsvendor model is used in solving inventory problems in which demand is random. In this thesis, we will focus on a method of using Monte Carlo sampling to estimate the order quantity that will either maximizes revenue or minimizes cost given that demand is uncertain. Given data, the Monte Carlo approach will be used in sampling data over scenarios and also estimating the probability density function. A bootstrapping process yields an empirical distribution for the order quantity that will maximize the expected profit. Finally, this method will be used …

Parametric Approaches To Fractional Programs: Analytical And Empirical Study, Chong Hyun Park

Open Access Dissertations

Fractional programming is used to model problems where the objective function is a ratio of functions. A parametric modeling approach provides effective technique for obtaining optimal solutions of these fractional programming problems. Although many heuristic algorithms have been proposed and assessed relative to each other, there are limited theoretical studies on the number of steps to obtain the solution. In this dissertation, I focus on the linear fractional combinatorial optimization problem, a special case of fractional programming where all functions in the objective function and constraints are linear and all variables are binary that model certain combinatorial structures. Two parametric …

Implementing And Testing A Panel-Based Method For Modeling Acoustic Scattering From Cfd Input, S. Hales Swift

Open Access Dissertations

Exposure of sailors to high levels of noise in the aircraft carrier deck environment is a problem that has serious human and economic consequences. A variety of approaches to quieting exhausting jets from high-performance aircraft are undergoing development. However, testing of noise abatement solutions at full-scale may be prohibitively costly when many possible nozzle treatments are under consideration. A relatively efficient and accurate means of predicting the noise levels resulting from engine-quieting technologies at personnel locations is needed. This is complicated by the need to model both the direct and the scattered sound field in order to determine the resultant …

Local Polynomial Chaos Expansion Method For High Dimensional Stochastic Differential Equations, Yi Chen

Open Access Dissertations

Polynomial chaos expansion is a widely adopted method to determine evolution of uncertainty in dynamical system with probabilistic uncertainties in parameters. In particular, we focus on linear stochastic problems with high dimensional random inputs. Most of the existing methods enjoyed the efficiency brought by PC expansion compared to sampling-based Monte Carlo experiments, but still suffered from relatively high simulation cost when facing high dimensional random inputs. We propose a localized polynomial chaos expansion method that employs a domain decomposition technique to approximate the stochastic solution locally. In a relatively lower dimensional random space, we are able to solve subdomain problems …

Numerical Computing With Functions On The Sphere And Disk, Heather Denise Wilber

Boise State University Theses and Dissertations

A new low rank approximation method for computing with functions in polar and spherical geometries is developed. By synthesizing a classic procedure known as the double Fourier sphere (DFS) method with a structure-preserving variant of Gaussian elimination, approximants to functions on the sphere and disk can be constructed that (1) preserve the bi-periodicity of the sphere, (2) are smooth over the poles of the sphere (and origin of the disk), (3) allow for the use of FFT-based algorithms, and (4) are near-optimal in their underlying discretizations. This method is used to develop a suite of fast, scalable algorithms that exploit …

An Exponential Time Differencing Scheme With A Real Distinct Poles Rational Function For Advection-Diffusion Reaction Equations, Emmanuel Owusu Asante-Asamani

Theses and Dissertations

A second order Exponential Time Differencing (ETD) scheme for advection-diffusion reaction systems is developed by using a real distinct poles rational function for approximating the underlying matrix exponential. The scheme is proved to be second order convergent. It is demonstrated to be robust for reaction-diffusion systems with non-smooth initial and boundary conditions, sharp solution gradients, and stiff reaction terms. In order to apply the scheme efficiently to higher dimensional problems, a dimensional splitting technique is also developed. This technique can be applied to all ETD schemes and has been found, in the test problems considered, to reduce computational time by …

Nonlocal Debye-Hückel Equations And Nonlocal Linearized Poisson-Boltzmann Equations For Electrostatics Of Electrolytes, Yi Jiang

Theses and Dissertations

Dielectric continuum models have been widely applied to the study of aqueous electrolytes since the early work done by Debye and Hückel in 1910s. Traditionally, they treat the water solvent as a simple dielectric medium with a permittivity constant without considering any correlation among water molecules. In the first part of this thesis, a nonlocal dielectric continuum model is proposed for predicting the electrostatics of electrolytes caused by any external charges. This model can be regarded as an extension of the traditional Debye Hückel equation. For this reason, it is called the nonlocal Debye-Hückel equation. As one important application, this …