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Type I Interferon Underlies Severe Disease Associated With Junín Virus Infection In Mice, Brady T. Hickerson, Eric J. Sefing, Kevin W. Bailey, Arnaud J. Van Wettere, Manuel L. Penichet, Brian B. Gowen
Type I Interferon Underlies Severe Disease Associated With Junín Virus Infection In Mice, Brady T. Hickerson, Eric J. Sefing, Kevin W. Bailey, Arnaud J. Van Wettere, Manuel L. Penichet, Brian B. Gowen
Animal, Dairy, and Veterinary Science Student Research
Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF). The pathogenesis underlying AHF is poorly understood; however, a prolonged, elevated interferon-α (IFN-α) response is associated with a negative disease outcome. A feature of all NWMs that cause viral hemorrhagic fever is the use of human transferrin receptor 1 (hTfR1) for cellular entry. Here, we show that mice expressing hTfR1 develop a lethal disease course marked by an increase in serum IFN-α concentration when challenged with JUNV. Further, we provide evidence that …
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry Of Junín Virus And Other Pathogenic New World Arenaviruses, Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, Brian B. Gowen
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry Of Junín Virus And Other Pathogenic New World Arenaviruses, Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, Brian B. Gowen
Animal, Dairy, and Veterinary Science Faculty Publications
Several clade B New World arenaviruses (NWAs) can cause severe and often fatal hemorrhagic fever, for which preventive and therapeutic measures are severely limited. These NWAs use human transferrin receptor 1 (hTfR1) as a host cell receptor for virus entry. The most prevalent of the pathogenic NWAs is Junín virus (JUNV), the etiological agent of Argentine hemorrhagic fever. Small animal models of JUNV infection are limited because most laboratory rodent species are refractory to disease. Only guinea pigs are known to develop disease following JUNV infection, but the underlying mechanisms are not well characterized. In the present study, we demonstrate …