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A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila 2021 Oregon Health & Science University

A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila

University Honors Theses

Background:

Poly Cystic Ovary Syndrome and Pelvic Floor Dysfunction are reproductive diseases with comorbidities whose novel relationship deserves further investigation.

Methods:

Levator Ani Muscle/Paravaginal Attachment was dissected from female Rhesus Macaque and subjected to tissue dissociation. Cells were treated with serum level hormones E2, T, and DHT. PCR, ICC, and IHC were used, followed by statistical analysis.

Results:

RNA analysis show differences in relative expression for endpoints ER, PR, AR, Ki-67, Col1A, and Vimentin. IHC along with ICC showed expression and localization in vivo.

Conclusions:

A novel in vitro model was created from macaque Levator Ani Muscle/Paravaginal Attachment ...


Reflecting On The Now: Race, Gender, Socio-Economic Status And Covid-19, Ariana Montemayor, Sydney M. Scanlon 2021 Old Dominion University

Reflecting On The Now: Race, Gender, Socio-Economic Status And Covid-19, Ariana Montemayor, Sydney M. Scanlon

VA Engage Journal

Early in 2020, we began a project for our Women and Technology class at Old Dominion University to highlight women working in health sciences. However, our original project idea drastically changed with the onset of the COVID-19 pandemic. COVID-19 focused our attention on issues regarding societal inequalities and health disparities. Therefore, we decided to create a new project that emphasized the societal inequalities and the disproportionate impact COVID had on People of Color, women and low-income individuals. In this paper, we critically reflect on the journey of our project from conception to completion, as well as how we, and the ...


Interventional Treatment With The Transjugular Intrahepatic Portosystemic Shunt (Tips) Procedure May Offer A Preferable Alternative To Systemic Anticoagulation In Patients With Cirrhosis And Portal Vein Thrombosis, Molly N. Pantelic 2021 Wayne State University School of Medicine

Interventional Treatment With The Transjugular Intrahepatic Portosystemic Shunt (Tips) Procedure May Offer A Preferable Alternative To Systemic Anticoagulation In Patients With Cirrhosis And Portal Vein Thrombosis, Molly N. Pantelic

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising:

Wang Z, Jiang MS, Zhang HL, et al. Is post-tips anticoagulation therapy necessary in patients with cirrhosis and portal vein thrombosis? A randomized controlled trial. Radiology. 2016;279(3):943-951. https://doi.org/10.1148/radiol.2015150369

for a patient with cryptogenic cirrhosis, gastroesophageal varices, pancreatic cancer, and portal vein thrombosis.


Luspatercept Diminishes The Need For Red Blood Cell Replacement In Transfusion-Dependent Β-Thalassemia Patients, Joudeh B. Freij 2021 Wayne State University School of Medicine

Luspatercept Diminishes The Need For Red Blood Cell Replacement In Transfusion-Dependent Β-Thalassemia Patients, Joudeh B. Freij

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising:

Cappellini MD, Viprakasit V, Taher AT, et al. A phase 3 trial of luspatercept in patients with transfusion-dependent β-thalassemia. N Engl J Med. 2020;382(13):1219-1231. https://doi.org/10.1056/NEJMoa1910182

for a patient with transfusion-dependent beta-thalassemia.


Sleeve Gastrectomy Improves Metabolic Syndrome In Psychologically Stable Patients With Schizophrenia, Irene Chen 2021 Wayne State University

Sleeve Gastrectomy Improves Metabolic Syndrome In Psychologically Stable Patients With Schizophrenia, Irene Chen

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising:

Archid R, Archid N, Meile T, Hoffman J, Wulff D, Teufel M, Muthig M, Quante M, Konigsrainer A, Lange J. Patients with schizophrenia do not demonstrate worse outcome after sleeve gastrectomy: a short-term cohort study. Obesity Surgery. 2019;29:506-510. https://doi.org/10.1007/s11695-018-3578-0

for a patient with schizophrenia and obesity.


External Beam Radiation Therapy Carries Lower Risk Of Sexual Dysfunction As Compared To Radical Prostatectomy In Treatment Of Patients With Localized Prostate Cancer, Aamod S. Dekhne 2021 Wayne State University School of Medicine

External Beam Radiation Therapy Carries Lower Risk Of Sexual Dysfunction As Compared To Radical Prostatectomy In Treatment Of Patients With Localized Prostate Cancer, Aamod S. Dekhne

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising:

Donovan JL, Hamdy FC, Lane JA, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. N Engl J Med. 2016;375(15):1425-1437. https://doi.org/10.1056/NEJMoa1606221

for a patient with localized prostate cancer and concerns regarding future sexual dysfunction.


Clinical Decision Science: Experience Can Be Shared; Can It Be Taught?, James Peter Meza 2021 Wayne State University School of Medicine

Clinical Decision Science: Experience Can Be Shared; Can It Be Taught?, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The editor reflects on the biopsychosocial model of clinical decision making and whether it can be taught in clinical medicine.


Primary Care Physician Perspectives On Screening For Axial Spondyloarthritis: A Qualitative Study, Kate L. Lapane, Divya Shridharmurthy, Sara Khan, Daniel Lindstrom, Ariel Beccia, Esther Yi, Jonathan Kay, Catherine E. Dube, Shao-Hsien Liu 2021 University of Massachusetts Medical School

Primary Care Physician Perspectives On Screening For Axial Spondyloarthritis: A Qualitative Study, Kate L. Lapane, Divya Shridharmurthy, Sara Khan, Daniel Lindstrom, Ariel Beccia, Esther Yi, Jonathan Kay, Catherine E. Dube, Shao-Hsien Liu

UMass Center for Clinical and Translational Science Supported Publications

BACKGROUND: Many patients with axial spondylarthritis (axSpA) experience lengthy diagnostic delays upwards of 14 years. (5-14 years). Screening tools for axSpA have been proposed for use in primary care settings, but whether this approach could be implemented into busy primary care settings remains unknown.

OBJECTIVE: To solicit feedback from primary care physicians regarding questions from the Inflammatory Back Pain Assessment: the Assessment of Spondyloarthritis International Society (ASAS) Expert Criteria and gain insight about barriers and facilitators for implementing axSpA screening in primary care.

METHODS: Guided by Consolidated Criteria for reporting Qualitative Research (COREQ-criteria), we recorded, transcribed, and analyzed in-depth interviews ...


Umccts Newsletter, May 2021, UMass Center for Clinical and Translational Science 2021 University of Massachusetts Medical School

Umccts Newsletter, May 2021, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the May 2021 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


The Population Affected By The Syndemic Of Covid-19 And Poverty Is More Likely To Be Hospitalized With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Stephen P. Furmanek, Meredith Cahill, Stephen S. Hanson, Ruth Carrico, Forest W. Arnold 2021 University of Louisville

The Population Affected By The Syndemic Of Covid-19 And Poverty Is More Likely To Be Hospitalized With Sars-Cov-2 Pneumonia, Julio A. Ramirez, Stephen P. Furmanek, Meredith Cahill, Stephen S. Hanson, Ruth Carrico, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Background

Lockdown measures to control COVID-19 have exacerbated the poverty epidemic. We hypothesized that the synergistic interaction of COVID-19 and poverty epidemics favors the development of more severe forms of COVID-19 in the population living in poverty. To test this hypothesis, we assessed whether an ecological association exists between the geographic distribution of hospitalized patients with SARS-CoV-2 pneumonia and markers of poverty in the city of Louisville, KY.

Methods

Using the geomasked home addresses of hospitalized patients with SARS-CoV-2 pneumonia in the city of Louisville, a kernel density heatmap was created. Kuldorff’s spatial scan statistic was used to calculate ...


Non-Selective Primary Human Tumor Cell Line Generation From Surgical Resections To Be Paired With Flash Frozen And Paraffin Embedded Tissue: Advancements In Democratizing Translational Research Materials To Rural Institutions, Jennifer Hawkins, Rebecca Russell, Logan M. Lawrence, Amrita Valluri, Jessica Wellman, Krista Denning 2021 Marshall University

Non-Selective Primary Human Tumor Cell Line Generation From Surgical Resections To Be Paired With Flash Frozen And Paraffin Embedded Tissue: Advancements In Democratizing Translational Research Materials To Rural Institutions, Jennifer Hawkins, Rebecca Russell, Logan M. Lawrence, Amrita Valluri, Jessica Wellman, Krista Denning

Marshall Journal of Medicine

Translational cancer research relies on the availability of human patient tissue demonstrating the specific disease process under investigation. Biobanks of human tissue have historically been and remain to date the primary access point for cancer research samples. Biorepositories routinely supply researchers with varying sample types for use in biomedical studies; most commonly formalin-fixed and paraffin-embedded (FFPE) tissue, or fresh snap-frozen tissue. In conjunction with preserved tissue samples, viable tumor cell lines derived from patient tissue have emerged to be a new gold standard in cancer research particularly in drug discovery and functional prognostic assays. Tissue banks providing these samples are ...


The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. McManus 2021 Emory University

The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. Mcmanus

Open Access Publications by UMMS Authors

Faced with the COVID-19 pandemic, the US system for developing and testing technologies was challenged in unparalleled ways. This article describes the multi-institutional, transdisciplinary team of the “RADx SM Tech Test Verification Core” and its role in expediting evaluations of COVID-19 testing devices. Expertise related to aspects of diagnostic testing was coordinated to evaluate testing devices with the goal of significantly expanding the ability to mass screen Americans to preserve lives and facilitate the safe return to work and school. Focal points included: laboratory and clinical device evaluation of the limit of viral detection, sensitivity, and specificity of devices in ...


The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. McManus 2021 University of Massachusetts Medical School

The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. Mcmanus

Open Access Publications by UMMS Authors

The National Institutes of Health (NIH) launched the Rapid Acceleration of Diagnostics (RADx SM ) Tech initiative to support the development and commercialization of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care test devices. The primary objective of the Clinical Studies Core (CSC) was to perform SARS-CoV-2 device studies involving diverse populations and settings. Within a few months, the infrastructure for clinical studies was developed, including a master protocol, digital study platform, data management system, single IRB, and multi-site partnerships. Data from some studies are being used to support Emergency Use Authorization of novel SARS-CoV-2 test devices. The CSC reduced ...


Streptococcus Anginosus Lung Infection And Empyema: A Case Report And Review Of The Literature, Nishita Tripathi, Kuldeep Ghosh, Anupama Raghuram 2021 University of Louisville

Streptococcus Anginosus Lung Infection And Empyema: A Case Report And Review Of The Literature, Nishita Tripathi, Kuldeep Ghosh, Anupama Raghuram

The University of Louisville Journal of Respiratory Infections

Streptococcus milleri group (SMG) also referred to as the Streptococcus anginosus group. These are Gram-positive, variable hemolysis, catalase negative, microaerophilic, non-motile facultative anaerobes which have been known to cause abscesses in humans. We report a case of empyema caused by Streptococcus anginosus in a patient with an unresolved pneumonia for over a month. In early October 2018, the patient presented to an emergency room with the complaints of shortness of air, productive cough, chills, subjective fever and weight loss for 4 weeks. A chest X-ray revealed a left lower lobe pneumonia. He was treated with 250 mg of azithromycin for ...


Characteristics And Outcomes Of Bacteremic Pneumococcal Pneumonia Of Patients With And Without Hiv Infection In Argentina, Alejandra González 2021 Posadas Hospital

Characteristics And Outcomes Of Bacteremic Pneumococcal Pneumonia Of Patients With And Without Hiv Infection In Argentina, Alejandra González

The University of Louisville Journal of Respiratory Infections

Streptococcus pneumoniae is the main causative agent of pneumonia, with a 10 to 25 percent rate of isolation in blood cultures. Controversies exist regarding the prognostic impact of a history of human immunodeficiency virus (HIV) infection on community-acquired pneumonia.

The aim of our work was to analyze and compare the clinical presentation, radiological findings and progression of pneumococcal pneumonia in patients infected with and not infected with HIV. We retrospectively analyzed adult patients with positive blood cultures for Streptococcus pneumoniae and clinical and radiological findings compatible with pneumonia in the period between January 2012 and May 2017. Age, sex, comorbidities ...


Invasive Pneumococcal Serotype 3 Disease Despite Pneumococcal Polysaccharide Vaccine-23, B. Frank Parker Jr, Forest W. Arnold 2021 University of Louisville, Louisville, KY

Invasive Pneumococcal Serotype 3 Disease Despite Pneumococcal Polysaccharide Vaccine-23, B. Frank Parker Jr, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Pneumococcal disease has a high global morbidity and mortality. We report a case of a 63-year old female with a history of vaccination with pneumococcal polysaccharide vaccine-23 (PPSV-23) who was transferred to a tertiary care facility with fever and seizures due to an unknown etiology. The diagnosis of invasive pneumococcal disease (IPD) was based the identification of Streptococcus pneumoniae in the blood (culture; serogroup 3) and cerebrospinal fluid (antigen), and the finding of purulence under pressure at craniotomy. The pneumococcal vaccine should provide protection from IPD. The findings reported here display that IPD can overcome immunity proffered by the pneumococcal ...


A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. McManus 2021 University of Massachusetts Medical School

A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus

COVID-19 Publications by UMMS Authors

The commercialization of medical devices and biotechnology products is characterized by high failure rates and long development lead times particularly among start-up enterprises. To increase the success rate of these high-risk ventures, the University of Massachusetts Lowell (UML) and University of Massachusetts Medical School (UMMS) partnered to create key academic support centers with programs to accelerate entrepreneurship and innovation in this industry. In 2008, UML and UMMS founded the Massachusetts Medical Device Development Center (M2D2), which is a business and technology incubator that provides business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to medical device ...


Barriers And Facilitators To Implementation Of Value-Based Care Models In New Medicaid Accountable Care Organizations In Massachusetts: A Study Protocol, Sarah L. Goff, Deborah Gurewich, Matthew Alcusky, Aparna Kachoria, Joanne Nicholson, Jay S. Himmelstein 2021 University of Massachusetts Amherst

Barriers And Facilitators To Implementation Of Value-Based Care Models In New Medicaid Accountable Care Organizations In Massachusetts: A Study Protocol, Sarah L. Goff, Deborah Gurewich, Matthew Alcusky, Aparna Kachoria, Joanne Nicholson, Jay S. Himmelstein

UMass Center for Clinical and Translational Science Supported Publications

Introduction: Massachusetts established 17 new Medicaid accountable care organizations (ACOs) and 24 affiliated Community Partners (CPs) in 2018 as part of a large-scale healthcare reform effort to improve care value. The new ACOs will receive $1.8 billion dollars in state and federal funding over 5 years through the Delivery System Reform Incentive Program (DSRIP). The multi-faceted study described in this protocol aims to address gaps in knowledge about Medicaid ACOs' impact on healthcare value by identifying barriers and facilitators to implementation and sustainment of the DSRIP-funded programs.

Methods and analysis: The study's four components are: (1) Document Review ...


To Preprint Or Not To Preprint, Forest W. Arnold, Kimberley A. Buckner, Alex Glynn, Jessica Petrey, Jose Bordon 2021 University of Louisville

To Preprint Or Not To Preprint, Forest W. Arnold, Kimberley A. Buckner, Alex Glynn, Jessica Petrey, Jose Bordon

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Umccts Newsletter, April 2021, UMass Center for Clinical and Translational Science 2021 University of Massachusetts Medical School

Umccts Newsletter, April 2021, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the April 2021 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


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