Cost-Effectiveness Analysis Of Tisagenlecleucel, Blinatumomab, And Clofarabine For Treatment Of B-Cell Precursor Acute Lymphoblastic Leukemia, Kamron Lotfi
Pharmaceutical Sciences (MS) Theses
Acute lymphoblastic leukemia (ALL) is a common type of adolescent and young adult leukemia in the United States (U.S.). Patients who are refractory or relapsed after receiving two or more lines of systemic therapy have the option of taking tisagenlecleucel. Due to the high cost of this treatment, a cost-effectiveness analysis was performed to assess the treatments for tisagenlecleucel, clofarabine combination, and blinatumomab. Objectives
The objective of this study is to evaluate the cost-effectiveness of tisagenlecleucel; clofarabine, etoposide, cyclophosphamide; and blinatumomab for the treatment of relapse- refractory ALL for adolescents and young adults from the U.S. health care ...
Research News, Grants, 2021, Volume 2, 2021 School of Pharmacy, University of Mississippi
Research News, Grants, 2021, Volume 2, Soumyajit Majumdar
Grants and contracts awarded during April - June 2021
School Of Pharmacy Intellectual Property Report Fy21, Fourth Quarter Report, 2021 School of Pharmacy, University of Mississippi
School Of Pharmacy Intellectual Property Report Fy21, Fourth Quarter Report, Soumyajit Majumdar
U. S. Patents, School of Pharmacy
School of Pharmacy Intellectual Property Report FY21, Fourth Quarter Report (as of 6/30/21)
Research News, Publications, 2021, Volume 2, 2021 School of Pharmacy, University of Mississippi
Research News, Publications, 2021, Volume 2, Soumyajit Majumdar
Publications that appeared during the period of April 1 through June 30, 2021
Longitudinal Evaluation Of Azithromycin And Cytokine Concentrations In Amniotic Fluid Following One-Time Oral Dosing In Pregnancy., 2021 Thomas Jefferson University
Longitudinal Evaluation Of Azithromycin And Cytokine Concentrations In Amniotic Fluid Following One-Time Oral Dosing In Pregnancy., Rupsa C. Boelig, Edwin Lam, Ankit Rochani, Gagan Kaushal, Amanda Roman, Walter K. Kraft
Department of Pharmacology and Experimental Therapeutics Faculty Papers
To utilize noninvasive collection of amniotic fluid in the setting of preterm premature rupture of membranes (PPROMs) to report the time concentration profile of azithromycin in amniotic fluid over 7 days from a single dose, and evaluate the correlation between azithromycin concentration and inflammatory markers in amniotic fluid. Prospective cohort study of five pregnant patients admitted with PPROMs and treated with a single 1 g oral azithromycin dose. Amniotic fluid was collected from pads and used to quantify azithromycin concentration as well as TNFa, IL-1a, IL-1b, IL-6, IL-8, and IL-10 concentrations. Primary outcome was time/concentration profile of azithromycin in ...
Potentiation Of Acetylcholine-Induced Relaxation Of Aorta In Male Uc Davis Type 2 Diabetes Mellitus (Ucd-T2dm) Rats: Sex-Specific Responses, Farjana Akther, Md Rahatullah Razan, Sonali Shaligram, James L. Graham, Kimber L. Stanhope, Kaitlin N. Allen, José Pablo Vázquez-Medina, Peter J. Havel, Roshanak Rahimian
School of Pharmacy Faculty Articles
Previous reports suggest that diabetes may differentially affect the vascular beds of females and males. The objectives of this study were to examine whether there were (1) sex differences in aortic function and (2) alterations in the relative contribution of endothelium-derived relaxing factors in modulating aortic reactivity in UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) rats. Endothelium-dependent vasorelaxation (EDV) in response to acetylcholine (ACh) was measured in aortic rings before and after exposure to pharmacological inhibitors. Relaxation responses to sodium nitroprusside were assessed in endothelium-denuded rings. Moreover, contractile responses to phenylephrine (PE) were measured before and after incubation of aortic ...
The Experience Of Off Periods In Parkinson’S Disease: Descriptions, Triggers, And Alleviating Factors, Sneha Mantri, Madeline Lepore, Briana Edison, Margaret Daeschler, Catherine Kopil, Connie Marras, Lana Chahine
Journal of Patient-Centered Research and Reviews
Purpose: Wearing off of Parkinson’s disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We aimed to assess the lived experience of OFF periods for people with Parkinson’s disease.
Methods: Participants in the longitudinal Fox Insight study who endorsed OFF periods were invited to complete a survey consisting of both multiple-choice and free-text responses. Descriptive statistics were used to summarize multiple-choice responses, and free-text responses were classified into themes through iterative discussion by 3 movement disorders specialists.
Results: A total of 2110 participants (52.4% male) completed the survey. Tremor was ...
Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, 2021 University of Kentucky
Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, Gavin T. Howington, Huy-Binh Nguyen, P. Brandon Bookstaver, Peter Akpunonu, Joshua T. Swan
Pharmacy Practice and Science Faculty Publications
No abstract provided.
Aacp Basic Resources For Pharmacy Education, 2021 University of Findlay
Aacp Basic Resources For Pharmacy Education, Jason Guy, Ivan Portillo, Robert D. Beckett, Leslie Ann Bowman, Daisy De La Rosa, Vern Duba, Juanita Draime, Kayce Gill, Neyda Gilman, Rebecca Hoover, Alison Kosnieczny, Scott Perkins
Library Association/Organization Work
"The AACP Basic Resources for Pharmacy Education is produced as a guide for those developing or maintaining the library collections that serve colleges and schools of pharmacy. The goal of the Basic Resources list is to make recommendations of books and other works to be included in pharmacy libraries, but not all titles are required to be purchased. Each pharmacy college has its own mission and its own program(s), and so each college’s library collection must reflect that mission and support the college’s program(s). Excellent library collections are built by knowledgeable librarians and drug information specialists ...
Utilizing Virtual Reality To Introduce Hospice And End-Of-Life Approaches, 2021 University of New England
Utilizing Virtual Reality To Introduce Hospice And End-Of-Life Approaches, Sydney P. Springer, George P. Allen
Pharmacy Practice Faculty Posters
Research poster describing the following:
The objective of this study was to assess changes in students’ comfort with talking about and caring for patients at EOL. A gap in the degree of instruction regarding palliative care in pharmacy curricula has been identified. The use of a virtual reality experience (VRE) has been shown to increase students’ understanding of and empathy for older adults with age-related conditions. We created a two-part palliative care series embedded into the 3rd professional year curriculum. Part one discussed perceptions of death and deprescribing at end-of-life (EOL). Part two used the Embodied Labs® VRE to follow ...
Impact Of A Meds To Beds Program On Re-Presentation Rates In Medical And Surgical Patients At A Community Hospital, Nowshin Islam, Aubrie Rafferty, Elizabeth L. Michalets
HCA Healthcare Journal of Medicine
While the benefits of bundled transitions of care services are understood, only a limited number of studies have analyzed the impact of a stand-alone bedside medication delivery service on repeat hospital encounters, and those published have reported mixed results.
A retrospective analysis was conducted in medical and surgical patients at a large community hospital. Adult patients discharged from either the cardiology, medicine, pulmonary, orthopedic/spine surgery, or women’s surgery unit and prescribed at least one new prescription upon discharge to home between September 2015 and March 2018 were included. The primary objective was to compare unplanned ...
Behavioral Analysis Of Conditions And Treatments Affecting Movement And Nociception, 2021 Rowan University
Behavioral Analysis Of Conditions And Treatments Affecting Movement And Nociception, Indu Mithra Madhuranthakam
Theses and Dissertations
This thesis work includes three projects. First part deals with the investigation of novel D2 receptor ligands in Prepulse inhibition. The goal of this study is to establish a relationship between dopamine receptor antagonists and agonists and prepulse inhibition which can then serve as a working model for an in-vivo efficacy of novel dopamine D2 drugs. The second part of the thesis work deals with Niemann pick disease type C. Niemann pick disease type C is a progressive genetic disorder that is characterized by the lysosomal accumulation of lipids which causes neurodegeneration, dementia, ataxia, and death. NPC1nmf164 mutant mice ...
Application Of Lean Six Sigma To Reduce The Cost Of Regulatory Noncompliance., 2021 Purdue University
Application Of Lean Six Sigma To Reduce The Cost Of Regulatory Noncompliance., Reham Nour, Chad Laux
International Conference on Lean Six Sigma
This research focused on the adoption of Six Sigma within FDA-regulated pharmaceutical companies to create an effective CAPA system for reducing the cost of noncompliance and supporting organizational performance.
This study utilized the DMAIC methodology, in a case study, to improve the CAPA process within a medical device company regulated by the FDA. All the critical requirements for compliance CAPA system was being defined from the FDA sources and the DMAIC model was be applied to improve and maintain CAPA performance.
Using the DMAIC approach supported identifying the bottlenecks and process variation ...
Differential Effect Of Proinflammatory Cytokines On Corneal And Conjunctival Epithelial Cell Mucins And Glycocalyx, Kiumars Shamloo, Priya Mistry, Ashley Barbarino, Christopher Ross, Vishal Jhanji
Pharmacy Faculty Articles and Research
Purpose: Ocular surface mucins and glycocalyx are critical for providing ocular hydration as well lubrication and repelling pathogens or allergens. Elevated levels of tear proinflammatory cytokines in dry eye may have detrimental effect on mucins and glycocalyx. The present study tested the effect of proinflammatory cytokines IL-6, TNF-α, and IFN-γ on membrane-tethered mucins expression, glycocalyx, and viability of ocular surface epithelial cells.
Methods: Stratified cultures of human corneal and conjunctival epithelial cells were exposed to different concentrations of IL-6, TNF-α, and IFN-γ for 24 hours. The mucins gene and protein expressions were quantified by real-time polymerase chain reaction (PCR) and ...
Engineering And Characterization Of Human Β-Defensin-3 And Its Analogues And Microcin J25 Peptides Against Mannheimia Haemolytica And Bovine Neutrophils, Harpreet Dhingra, Kamaljit Kaur, Baljit Singh
Pharmacy Faculty Articles and Research
Mannheimia haemolytica-induced bovine respiratory disease causes loss of millions of dollars to Canadian cattle industry. Current antimicrobials are proving to be ineffective and leave residues in meat. Antimicrobial peptides (AMPs) may be effective against M. haemolytica while minimizing the risk of drug residues. Cationic AMPs can kill bacteria through interactions with the anionic bacterial membrane. Human β-Defensin 3 (HBD3) and microcin J25 (MccJ25) are AMPs with potent activity against many Gram-negative bacteria. We tested the microbicidal activity of wild-type HBD3, three HBD3 peptide analogues (28 amino acid, 20AA, and 10AA) derived from the sequence of natural HBD3, and MccJ25 ...
Report Of The National Institutes Of Health Sars-Cov-2 Antiviral Therapeutics Summit, 2021 National Institutes of Health
Report Of The National Institutes Of Health Sars-Cov-2 Antiviral Therapeutics Summit, Matthew D. Hall, James M. Anderson, Celia A. Schiffer, Anthony J. Conley, Mindy I. Davis
COVID-19 Publications by UMMS Authors
The NIH Virtual SARS-CoV-2 Antiviral Summit, held on November 6, 2020, was organized to provide an overview on the status and challenges in developing antiviral therapeutics for COVID-19, including combinations of antivirals. Scientific experts from the public and private sectors convened virtually during a live videocast to discuss SARS-CoV-2 targets for drug discovery as well as the preclinical tools needed to develop and evaluate effective small molecule antivirals. The goals of the Summit were to review the current state of the science, identify unmet research needs, share insights and lessons learned from treating other infectious diseases, identify opportunities for public-private ...
Cenobamate, A Sodium Channel Inhibitor And Positive Allosteric Modulator Of Gabaa Ion Channels, For Partial Onset Seizures In Adults: A Comprehensive Review And Clinical Implications, 2021 Louisiana State University
Cenobamate, A Sodium Channel Inhibitor And Positive Allosteric Modulator Of Gabaa Ion Channels, For Partial Onset Seizures In Adults: A Comprehensive Review And Clinical Implications, Dustin R. Latimer, Amber N. Edinoff, Rachel D. Ruff, Kelsey C. Rooney, Kayla M. Penny, Shaan B. Patel, Suresh Sabbenahalli, Adam M. Kaye, Elyse M. Cornett, Omar Viswanath, Ivan Urits, Alan D. Kaye
School of Pharmacy Faculty Articles
Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment. Current FDA approved drugs have been shown to have similar efficacy; however, they all share a commonality of having side effects that have the potential to significantly reduce a patient’s quality of life. Cenobamate, a newly-FDA approved drug used to treat partial-onset seizures in adult patients, has demonstrated promise in that it works on two proposed mechanisms that are commonly associated with epilepsy. Cenobamate ...
The Preparation Temperature Influences The Physicochemical Nature And Activity Of Nanoceria, 2021 University of Kentucky
The Preparation Temperature Influences The Physicochemical Nature And Activity Of Nanoceria, Robert A. Yokel, Wendel Wohlleben, Johannes Georg Keller, Matthew L. Hancock, Jason M. Unrine, D. Allan Butterfield, Eric A. Grulke
Pharmaceutical Sciences Faculty Publications
Cerium oxide nanoparticles, so-called nanoceria, are engineered nanomaterials prepared by many methods that result in products with varying physicochemical properties and applications. Those used industrially are often calcined, an example is NM-212. Other nanoceria have beneficial pharmaceutical properties and are often prepared by solvothermal synthesis. Solvothermally synthesized nanoceria dissolve in acidic environments, accelerated by carboxylic acids. NM-212 dissolution has been reported to be minimal. To gain insight into the role of high-temperature exposure on nanoceria dissolution, product susceptibility to carboxylic acid-accelerated dissolution, and its effect on biological and catalytic properties of nanoceria, the dissolution of NM-212, a solvothermally synthesized nanoceria ...
Evaluation Of Somatic Mutations In Solid Metastatic Pan-Cancer Patients, 2021 Chapman University
Evaluation Of Somatic Mutations In Solid Metastatic Pan-Cancer Patients, Moom Roosan, Isa Mambetsariev, Rebecca Pharaon, Jeremy Fricke, Angel R. Baroz, Joseph Chao, Chen Chen, Mohd W. Nasser, Ramakanth Chirravuri-Venkata, Maneesh Jain, Lynette Smith, Susan E. Yost, Karen L. Reckamp, Raju Pillai, Leonidas Arvanitis, Michelle Afkhami, Edward W. Wang, Vincent Chung, Mihaela Cristea, Marwan Fakih, Marianna Koczywas, Erminia Massarelli, Joanne Mortimer, Yuan Yuan, Surinder K. Batra, Sumanta Pal, Ravi Salgia
Pharmacy Faculty Articles and Research
Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx® panel. The most prevalent genes with somatic mutations were TP53, KRAS, APC, and LRP1B. In this analysis, these genes had mutation frequencies higher than in publicly available datasets. We identified that the somatic mutations were seven mutually exclusive gene pairs and an additional fifty-two co-occurring gene pairs. Mutations in ...
Pharmacy Newsletter : June 2021, 2021 Aga Kahn University Hospital
Pharmacy Newsletter : June 2021, Pharmacy Department
- Role of Pharmacist to Overcome the Challenges related to COVID-19 Vaccines
- Myths & Facts about COVID-19 Vaccine
- Medication Loss in the Tubing while Administration
- One Pill can kill | Advancing your knowledge of Paediatric Toxicology
- Chronic Therapy Medications During the Perioperative Period: To Continue or Discontinue?