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Bidirectional Interference Between Speech And Postural Stability In Individuals With Parkinson's Disease, Christopher Dromey, Eon Jarvis, Stuart Sondrup, Shawn Nissen, K. Bo Foreman, Leland E. Dibble 2010 Brigham Young University

Bidirectional Interference Between Speech And Postural Stability In Individuals With Parkinson's Disease, Christopher Dromey, Eon Jarvis, Stuart Sondrup, Shawn Nissen, K. Bo Foreman, Leland E. Dibble

Faculty Publications

Because people frequently talk while engaged in other activities, and because Parkinson's disease (PD) is known to diminish multi-tasking performance, we examined dual task interference between speaking and postural stability in 9 individuals with PD, 7 age-matched and 10 healthy young controls. Participants repeated a target utterance and performed a rise to toes task in both single and dual task conditions. Diphthong transitions were measured from audio recordings and postural variables reflecting planning, coordination, and stability were derived from a multi-camera motion capture system and force plate recordings. Thus, sensitive measures of both control groups for the isolated postural ...


Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson Disease, Christopher Dromey 2010 Brigham Young University

Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson Disease, Christopher Dromey

Faculty Publications

No abstract provided.


Vocal Fold Bowing In Elderly Male Monozygotic Twins: A Case Study, Kristine Tanner, Cara Sauder, Susan L. Thibeault, Christopher Dromey, Marshall E. Smith 2010 The University Of Utah

Vocal Fold Bowing In Elderly Male Monozygotic Twins: A Case Study, Kristine Tanner, Cara Sauder, Susan L. Thibeault, Christopher Dromey, Marshall E. Smith

Faculty Publications

Objectives: This study examined case histories, diagnostic features, and treatment response in two 79-year-old male monozygotic (identical) twins with vocal fold bowing, exploring both genetic and environmental factors.
Study Design: Case study.
Methods: DNA concordance was examined via cheek swab. Case histories, videostroboscopy, auditory- and visual-perceptual assessment, electromyography, acoustic measures, and Voice Handicap ratings were undertaken. Both twins underwent surgical intervention and subsequent voice therapy.
Results: Monozygosity was confirmed for DNA polymorphisms, with 10 of 10 concordance for STR DNA markers. For both twins, auditory and visual-perceptual assessments indicated severe bowing, hoarseness and breathiness, although Twin 1 was judged to ...


Curriculum Development And Pilot Program Of Preconception Planning For Latinas, Esperanza Gutierrez 2010 Rhode Island College

Curriculum Development And Pilot Program Of Preconception Planning For Latinas, Esperanza Gutierrez

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Preconception planning is gaining popularity and is a promising method of improving pregnancy outcomes. The need to incorporate this kind of education in various settings is also identified in the literature. According to the March of Dimes, between 2004-2006 Hispanics had one of the highest preterm birth rate of 12.1% in the U.S. and 13.6o/o in RI (March of Dimes, 2009). In addition, during the same years RI statistics on low birth weight infants among Hispanics were 8.3% and 6.9% in the U.S. Healthy People 2010 suggested that this rate should be no ...


Pepfar Special Initiative On Sexual And Gender-Based Violence: Baseline Report, Lynne Elson, Jill Keesbury 2010 Population Council

Pepfar Special Initiative On Sexual And Gender-Based Violence: Baseline Report, Lynne Elson, Jill Keesbury

HIV and AIDS

The PEPFAR Special Initiative on Sexual and Gender-Based Violence aims to strengthen services for survivors of sexual violence (SV) though the implementation of a comprehensive model of care in participating PEPFAR partner facilities. This baseline report examines project sites in Uganda and Rwanda and suggests strengthening health services involving training, community and provider awareness and attitudes.


Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula 2010 Louisiana State University and Agricultural and Mechanical College

Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula

LSU Doctoral Dissertations

Hypertension is a major predisposing factor for the development of cardiovascular and renal diseases. The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases such as hypertension, myocardial infarction, heart failure, and stroke. Angiotensin II (Ang II), the effector peptide of the RAS, activates a wide spectrum of signaling responses via the Ang II type-I receptor that mediate its physiological control of blood pressure, thirst and sodium balance. For the past two decades, increasing evidence has demonstrated that the circulatory RAS and local/tissue RAS components (heart and brain) may contribute to the development of hypertensive ...


Identification Of A Tumor-Targeting-Peptide And Development Of A Tumor-Targeted-Cytokine Vector For Systemic Treatment Of Primary And Metastatic Malignancies, Jeffry Cutrera 2010 Louisiana State University and Agricultural and Mechanical College

Identification Of A Tumor-Targeting-Peptide And Development Of A Tumor-Targeted-Cytokine Vector For Systemic Treatment Of Primary And Metastatic Malignancies, Jeffry Cutrera

LSU Doctoral Dissertations

Advances in cancer therapies continue to be improved, yet cancer continues to be one of the deadliest diseases in the world. Harnessing the power of the body’s immune system to attack cancer is a promising strategy that can further improve therapies for neoplastic diseases. As part of this strategy, cytokines such as interleukin (IL) 2 and interferon á are currently accepted cancer treatments, and other cytokines such as IL12 and GM-CSF also show potential as new treatments. Clinical trials with these cytokines have shown less than acceptable therapeutic efficacy and toxicities, but tumor-targeting motifs can improve these effects. Both ...


Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli 2010 Louisiana State University and Agricultural and Mechanical College

Ospc In The Pathogenesis Of Borrelia Burgdorferi, Sunita V. Seemanapalli

LSU Doctoral Dissertations

Lyme disease is a multisystem disorder caused by the tick vector Borrelia burgdorferi. During its life cycle between the tick vector and the mammalian host, Borrelia up- and down-regulates the expression of its surface lipoproteins. Of its many surface lipoproteins, the Outer surface protein C (OspC) is crucial for initial mammalian infection. OspC has a common role shared with other lipoproteins of protection against host innate defences and a unique function in facilitating the dissemination of B. burgdorferi in the murine host. The structure of OspC was solved in 2001 and the lipoprotein was found to be predominantly alpha-helical with ...


Aromatase Gene Polymorphisms Are Associated With Survival Among Patients With Cardiovascular Disease In A Sex-Specific Manner, Amber L. Beitelshees, Julie A. Johnson, Megan L. Hames, Yan Gong, Rhonda M. Cooper-DeHoff, Jun Wu, Sharon Cresci, Cynthia X. Ma, Carl J. Pepine, Michael A. Province, John A. Spertus, Howard L. McLeod 2010 University of Maryland - College Park

Aromatase Gene Polymorphisms Are Associated With Survival Among Patients With Cardiovascular Disease In A Sex-Specific Manner, Amber L. Beitelshees, Julie A. Johnson, Megan L. Hames, Yan Gong, Rhonda M. Cooper-Dehoff, Jun Wu, Sharon Cresci, Cynthia X. Ma, Carl J. Pepine, Michael A. Province, John A. Spertus, Howard L. Mcleod

Open Access Publications

No abstract provided.


Investigation Of A Classroom-Based Reading Intervention Strategy For Older Elementary Students With Poor Decoding Skills, Shara Brinkley 2010 Louisiana State University and Agricultural and Mechanical College

Investigation Of A Classroom-Based Reading Intervention Strategy For Older Elementary Students With Poor Decoding Skills, Shara Brinkley

LSU Doctoral Dissertations

Using a response to intervention framework, this study investigates the efficacy of a classroom-based intervention for struggling readers with decoding deficits in the upper elementary grades. Twenty two students in the fourth and sixth grades from four classrooms in low-performing schools received either a short 20-minute intervention delivered by their teacher or access to the lessons for an equivalent amount of time but no teacher instruction. Using three orthographic patterns, the 24 lessons consisted of a series of ten minimally contrasted words differing by one letter. The students in the experimental group decoded the words using a visual alphabet (Phonic ...


In Vivo And In Vitro Pathogenesis Of Francisella Asiatica In Tilapia Nilotica (Oreochromis Niloticus), Esteban Soto 2010 Louisiana State University and Agricultural and Mechanical College

In Vivo And In Vitro Pathogenesis Of Francisella Asiatica In Tilapia Nilotica (Oreochromis Niloticus), Esteban Soto

LSU Doctoral Dissertations

Francisella asiatica is a Gram negative, facultative intracellular pathogen that causes fish francisellosis. In this project, homologues to the F. tularensis iglABCD genes were found present in F. asiatica. As few as 23 F. asiatica bacteria injected in the peritoneum were found capable of causing mortalities in tilapia nilotica (Oreochromis niloticus), and even fewer were enough to cause pathological changes. We examined the in vivo and in vitro interaction of F. asiatica wild type (WT) and a ÄiglC strain with tilapia and tilapia head kidney derived macrophages (HKDM). The ÄiglC was found to be attenuated following intraperitoneal and immersion challenges ...


The Auxiliary System Of Typically Developing Children Acquiring African American English, Brandi Lynette Newkirk 2010 Louisiana State University and Agricultural and Mechanical College

The Auxiliary System Of Typically Developing Children Acquiring African American English, Brandi Lynette Newkirk

LSU Doctoral Dissertations

This study’s purpose was to examine the acquisition and use of BE, DO, and modal auxiliaries by African American English (AAE)-speaking children. The impetus for this work was the lack of information regarding the developmental trajectory of these auxiliary types and their use, in AAE relative to what is known about auxiliary acquisition and use in Mainstream American English (MAE). The study used two datasets of language samples: one that contained 48 language samples from 3 ½-year-old children and one that contained 36 longitudinal language samples of five children who were between 18 and 51 months of age ...


Role Of Gastrointestinal Multidrug Resistance (Mdr1) Gene And P-Glycoprotein (P-Gp) In The Oral Absorption Of Methadone In Horses, Renata Lehn Linardi 2010 Louisiana State University and Agricultural and Mechanical College

Role Of Gastrointestinal Multidrug Resistance (Mdr1) Gene And P-Glycoprotein (P-Gp) In The Oral Absorption Of Methadone In Horses, Renata Lehn Linardi

LSU Doctoral Dissertations

Methadone is a mu-opioid receptor agonist which is a very effective analgesic used to treat moderate to severe acute and chronic pain in humans. Due to methadone’s minimal undesirable side-effects in people, we believed it could be of use in horses as an analgesic agent. As found with the majority of lipophilic drugs, absorption of methadone occurs primarily in the small intestine via transcellular transport and its absorption is regulated by P-glycoprotein. P-glycoprotein is a transmembrane transporter protein encoded by the multidrug resistance gene, which is constitutively expressed in the apical membrane of enterocytes of various species. This protein ...


Behaviors And Beliefs Of African American Caregivers As Related To Their Children's Language-Literacy Development, Lekeitha Renee' Morris 2010 Louisiana State University and Agricultural and Mechanical College

Behaviors And Beliefs Of African American Caregivers As Related To Their Children's Language-Literacy Development, Lekeitha Renee' Morris

LSU Doctoral Dissertations

This study examined African American (AA) caregivers’ beliefs about their children’s language-literacy development and their book reading behaviors with their children as a function of socioeconomic status (SES). Caregivers’ behaviors were examined before, during, and after a three-day caregiver training program that targeted four behaviors (i.e., tracking print, reference to print, text to life, and interpretations). Participants were 20 caregiver-child dyads classified as Low-SES (LSES) or Middle-SES (MSES) based on the caregivers’ level of education. Children were typically developing girls between the ages of four and five years. At pre-test, the two groups of caregivers differed in some ...


Depolarization By Transient Receptor Potential Melastatin 4 In Pancreatic Alpha-Cells Regulates Glucagon Secretion, Piper Lynn Nelson 2010 Louisiana State University and Agricultural and Mechanical College

Depolarization By Transient Receptor Potential Melastatin 4 In Pancreatic Alpha-Cells Regulates Glucagon Secretion, Piper Lynn Nelson

LSU Master's Theses

The Transient Receptor Potential Melastatin 4 protein (TRPM4) is a member of the TRP family of ion channels that is expressed in both electrically excitable and non-excitable cells. Functional studies revealed that TRPM4 significantly impacts Ca2+ signals in both immune and pancreatic β-cells, which is important for cellular processes such as hormone secretion. However, its role in glucagon secreting α-cells has not been reported. Type 2 Diabetes Mellitus is often associated with increased glucagon levels; yet, the exact mechanism controlling its secretion is not known. In pancreatic α-cells, an increase in intracellular Ca2+ concentration causes glucagon secretion. We hypothesize that ...


The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill 2010 Louisiana State University and Agricultural and Mechanical College

The Role Of Bone Marrow In Siv Pathogenesis Using The Rhesus Macaque Model, Amy F. Gill

LSU Doctoral Dissertations

CD4+ memory T cells are depleted in mucosal tissues post human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection without restoration to pre-infection levels during progressive course of disease. Bone marrow (BM) as a hematopoietic organ has been investigated for hematologic and morphologic changes during HIV infection. However, BM as a primary lymphoid tissue during HIV infection has been poorly characterized. We proposed BM was also a site of CD4+ T cell depletion driven by increased apoptosis during progressive HIV disease. We chose to investigate bone marrow changes using the premier non-human primate Rhesus macaque SIV model for the ...


Comparative Validity Of Mmpi-A Scales Scores In African American And Caucasian Male Juvenile Delinquents, Stacy Natasha Wilson 2010 Old Dominion University

Comparative Validity Of Mmpi-A Scales Scores In African American And Caucasian Male Juvenile Delinquents, Stacy Natasha Wilson

Psychology Theses & Dissertations

This study examined comparative validity of the MMPI-A scale scores of African American and Caucasian male juvenile delinquents utilizing a step down hierarchical regression procedure proposed by Laughtenschlager & Mendoza (1986). The MMPI-A (Butcher et al., 1992) was administered to 281 African American and Caucasian juvenile delinquents while their caretakers filled out the CBCL (Achenbach, 1991; Achenbach & Rescorla, 2001) and DBRS (Barkley & Murphy, 1998), which were used as extra-test measures. Significant overall prediction bias was detected in 15 out of 56 regressions. Statistically significant prediction bias was found for a subset of criterion variables for Clinical Scales 2, 4, and 9, as well as Content Scales A-dep, A-hea, A-ang, and A-con and Supplementary Scale IMM. Slope bias was found for A-hea with "DSM-Oriented Somatic Problems". Statistically significant intercept ...


In Vitro And In Vivo Evaluation Of A Brucella Putative Hemagglutinin, Lauren E. Duhon 2010 Louisiana State University and Agricultural and Mechanical College

In Vitro And In Vivo Evaluation Of A Brucella Putative Hemagglutinin, Lauren E. Duhon

LSU Doctoral Dissertations

Brucellosis, a zoonotic disease caused by Brucella spp., presents both health and economic difficulties for livestock, wildlife, and humans. While brucellosis is nearly eradicated in the United States, the disease remains detrimental in many countries worldwide. Attempts to produce a safe and effective small ruminant vaccine have been met with limited success. The current vaccine for bovine brucellosis in the United States is B. abortus RB51. This strain transiently colonizes the host and induces a cell-mediated immune response. Levels of protection have not been demonstrated in goats and thus it is considered a relatively poor caprine vaccine that probably does ...


The Association Between Parental Perceptions Of Children's Residential Mental Health Treatment And The Parent-Child Relationship, Susanne Elizabeth Preston 2010 Old Dominion University

The Association Between Parental Perceptions Of Children's Residential Mental Health Treatment And The Parent-Child Relationship, Susanne Elizabeth Preston

Counseling & Human Services Theses & Dissertations

Residential mental health treatment for children as an intervention for children is increasing, potentially affecting the relationship within families. The purpose of this study was to examine the parental perspectives of the associations between the parent-child relationship and children's residential mental health treatment. This study explored parental perspectives of specific aspects of the parent-child relationship: parental support, satisfaction with parenting, parental involvement, communication, and limit setting-and the association between these aspects and the child's residential mental health treatment. Paired samples t-tests were conducted; resulting in statistically significant changes on all scales measured, with varying effect sizes. Results ...


Treatment Effect Of Maximum Performance Speech Therapy For Individuals With Parkinson's Disease And Dysarthria, Heidi Huckabee Michiels 2010 Louisiana State University and Agricultural and Mechanical College

Treatment Effect Of Maximum Performance Speech Therapy For Individuals With Parkinson's Disease And Dysarthria, Heidi Huckabee Michiels

LSU Master's Theses

The Lee Silverman Voice Treatment (LSVT™) has received much attention in the past decade for its use in the treatment of individuals with Parkinson’s disease (Jones, 2005; Ramig, Countryman, O'Brien, Hoehn, & Thompson, 1996; Ramig, Sapir, Countryman et al., 2001; Wohlert, 2004). This intensive program requires therapy four times a week for four weeks in order to improve perceptual characteristics of the voice, such as loudness. However, since LSVT™ was introduced, the rehabilitation industry has experienced systematic reductions in allowable frequency and duration of covered services. The result has been that individuals often cannot qualify for the rigorous LSVT™ protocol (Centers ...


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