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Dissecting The Biosyntheses Of Gilvocarcins And Ravidomycins, Madan Kumar Kharel 2010 University of Kentucky

Dissecting The Biosyntheses Of Gilvocarcins And Ravidomycins, Madan Kumar Kharel

University of Kentucky Doctoral Dissertations

Gilvocarcin V (GV) and ravidomycin (RMV) exhibit excellent antitumor activities in the presence of near-UV light at low concentration maintaining a low in vivo cytotoxicity. Although, the exact molecular mechanism for in vivo actions of these antibiotics has yet to be determined, a [2+2] cycloaddition reaction of the vinyl side chain with DNA thymidine residues in addition to the inhibition of topoisomerase II and DNAhistone H3 cross-linking are reported for the GV’s mechanism of action. Such activities have made these molecules interesting candidates for the biosynthetic investigation to generate analogues with improved activity/solubility. Previous biosynthetic studies have ...


Function Of Androgen Receptor In Prostate Cancer Epithelial Mesenchymal Transition And Microtubule Targeting, Menglei Zhu 2010 University of Kentucky

Function Of Androgen Receptor In Prostate Cancer Epithelial Mesenchymal Transition And Microtubule Targeting, Menglei Zhu

University of Kentucky Doctoral Dissertations

Prostate cancer is the most frequently diagnosed non-skin cancer and the third leading cause of cancer mortality among men in the US. Androgens are functionally required for the normal growth of the prostate gland and play a critical role in prostate tumor development and progression. Epithelial-mesenchymal-transition (EMT) is an important process during normal development, and cancer cell metastasis.

This study examined the ability of androgens to influence EMT of prostate cancer epithelial cells and evaluate the effect of taxol chemotherapy on androgen signaling in prostate cancer cells in prostate cancer. The EMT pattern was evaluated on the basis of expression ...


Vegetarians And Vegans In Kentucky, Danita Martha Hines 2010 University of Kentucky

Vegetarians And Vegans In Kentucky, Danita Martha Hines

University of Kentucky Master's Theses

Kentucky has a health crisis and most of the causes can be linked to diet, smoking and physical activity. Vegetarian and vegan diets have numerous benefits for many diet related health problems such as obesity, heart disease, Type 2 diabetes and certain cancers. There has been limited research on vegetarians and vegans in the United States and none in Kentucky. This study used an anonymous electronic survey to examine the different characteristics, behaviors, experiences and opinions of adult vegetarians and vegans in Kentucky. Results were compared to statistical data reported on the general population of Kentucky. Calculated body mass index ...


Impact Of A 16-Week Behavioral Weight-Loss Program On Dietary And Physical Activity Changes, Eunkyung Lee 2010 University of Kentucky

Impact Of A 16-Week Behavioral Weight-Loss Program On Dietary And Physical Activity Changes, Eunkyung Lee

University of Kentucky Master's Theses

Behavioral weight loss programs have been shown to be effective for short-term weight loss, however the impact of these programs on dietary changes is unclear. This study examined the changes in participant’s diet and physical activity over the course of a 16-week Internet behavioral weight-loss program. A single-center randomized controlled trial was conducted from August 2008 to December 2008 in Lexington, KY, and sixty-six women whose mean (SD) age was 48.6 (10.8) years and body mass index was 31.8 (3.7) kg/m2 completed all dietary and physical measures. Participants received two face-to-face group sessions ...


Foothills Academy: A Program Ranking And Comparative Analysis Of Residential Treatment Programs, William Aaron 2010 University of Kentucky

Foothills Academy: A Program Ranking And Comparative Analysis Of Residential Treatment Programs, William Aaron

MPA/MPP Capstone Projects

The Foothills Academy is an all male adolescent residential treatment facility in Albany, Kentucky. As more states turn toward alternative treatment options to address the growing needs of youth suffering from mental and emotional disorders and substance abuse issues, demand for more efficient treatment programs is on the rise. To remain competitive and to administer the best treatment services for their clients, residential treatment programs must utilize industry best practices that allow efficient use of public funds. By identifying high performing programs, those programs may then be studied to identify factors key to individual program success.

My findings were consistently ...


The Cost Of Medication Errors In The Emergency Department: Implications For Clinical Pharmacy Practice, Benjamin Bowman 2010 University of Kentucky

The Cost Of Medication Errors In The Emergency Department: Implications For Clinical Pharmacy Practice, Benjamin Bowman

MPA/MPP Capstone Projects

Introduction

The main purpose of this capstone project is to provide an objective analysis of the cost of a medication error in the emergency department. The secondary objective of this analysis is to estimate the cost avoidance impact of providing clinical pharmacy services in the emergency department (ED).

Literature review

Previous literature has described the scope of clinical pharmacy services in the ED and has, to some extent, presented economic outcomes analyses of the impact of these services (Cohen et al., 2009; Lada and Delgado, 2007). According to Cohen et al., the current literature is still lacking a formal pharmacoeconomic ...


What Is The Impact Of Kentucky’S Pharmacy Recovery Network?, Benjamin Paul Clark 2010 University of Kentucky

What Is The Impact Of Kentucky’S Pharmacy Recovery Network?, Benjamin Paul Clark

MPA/MPP Capstone Projects

Problem Statement: This capstone will focus on Kentucky’s Pharmacy Recovery Network (PRN). In general, professional recovery networks are organizations that act as a liaison between professional state boards and the health professionals who are dealing with substance abuse and addictions that sometimes result in negative consequences to that individual and/or their profession. Instead of a “one-strike and you are out” approach, these organizations recognize that there is a disease process occurring. Thus, as opposed to engaging in strictly punitive measures, a rehabilitative approach is chosen to allow the health professional an opportunity to recover and successfully reenter into ...


Community Needs Assessment Of Mayasandra Village, Karnataka, India, Alexander Hernandez Holl 2010 University of Kentucky

Community Needs Assessment Of Mayasandra Village, Karnataka, India, Alexander Hernandez Holl

MPA/MPP Capstone Projects

No executive summary.


The Relationship Between Obesity And Skin And Soft Tissue Infections, Juliana Swiney 2010 University of Kentucky

The Relationship Between Obesity And Skin And Soft Tissue Infections, Juliana Swiney

MPA/MPP Capstone Projects

The Problem:

It is well known that our country is experiencing an obesity epidemic: 33.9% of all adults are obese (BMI>30) and 67% of adults are either overweight or obese (BMI>25). Obesity is a risk factor for several serious disease states such as, diabetes, stroke, hypertension, heart disease and some types of cancer. It also has a less well defined relationship with skin and soft tissue infections.

Although it is known that excessive weight increases the opportunity for harmful skin conditions, this relationship has not been as well studied. Some of the mechanisms that predispose obese people ...


Vowel Recognition From Continuous Articulatory Movements For Speaker-Dependent Applications, Jun Wang, Jordan R. Green, Ashok Samal, Tom D. Carrell 2010 University of Nebraska-Lincoln

Vowel Recognition From Continuous Articulatory Movements For Speaker-Dependent Applications, Jun Wang, Jordan R. Green, Ashok Samal, Tom D. Carrell

Special Education and Communication Disorders Faculty Publications

A novel approach was developed to recognize vowels from continuous tongue and lip movements. Vowels were classified based on movement patterns (rather than on derived articulatory features, e.g., lip opening) using a machine learning approach. Recognition accuracy on a single-speaker dataset was 94.02% with a very short latency. Recognition accuracy was better for high vowels than for low vowels. This finding parallels previous empirical findings on tongue movements during vowels. The recognition algorithm was then used to drive an articulation-to-acoustics synthesizer. The synthesizer recognizes vowels from continuous input stream of tongue and lip movements and plays the corresponding ...


Dr. Cezanne And The Art Of Re(Peat)Search: Competing Interests And Obligations In Clinical Research, Robyn L. Bluhm, Jocelyn Downie, Jeff Nisker 2010 Old Dominion University

Dr. Cezanne And The Art Of Re(Peat)Search: Competing Interests And Obligations In Clinical Research, Robyn L. Bluhm, Jocelyn Downie, Jeff Nisker

Philosophy Faculty Publications

Clinician researchers have a number of roles, each of which carries specific obligations. There are times when these obligations may be in competition (up to and including conflict) with each other. Using a narrative case study that describes a group of colleagues discussing their clinical department's participation in an industry-sponsored research protocol, we illustrate a number of the obligations faced by clinician researchers, and discuss how competing interests and obligations can lead to ethical problems. The case study is followed by a discussion of the effect of university-industry relations on competing interests and obligations in both clinical research and ...


Volume 7, Number 1 (Fall/Winter 2010), UT Institute of Agriculture 2010 University of Tennessee, Knoxville

Volume 7, Number 1 (Fall/Winter 2010), Ut Institute Of Agriculture

Tennessee Land, Life and Science Magazine

Issue Highlights:

  • UT AgResearch Discoveries that Make a Difference
  • Taking Steps to Protect U.S. Agriculture and Food Supply
  • Student Biosystems Teams Shine in International Competitions


The Biology Of Reality Testing - Implications For Cognitive Education, Neil Greenberg 2010 University of Tennessee - Knoxville

The Biology Of Reality Testing - Implications For Cognitive Education, Neil Greenberg

Faculty Publications and Other Works -- Ecology and Evolutionary Biology

• This report explores the proposition that teaching effectiveness can be enhanced by accommodating the key differences between two complementary and deeply engrained modes of reality testing, each predominantly centered in different hemispheres of the brain. • (1) Correspondence involves “reality-testing” of a percept, the cerebral representation of an experience in the world. • (2) Coherence involves “textualizing”, that is, reality-testing of a percept by how easily it relates to previous and ongoing parallel and collateral experiences. • Confidence in the validity of any percept throughout development is related to the interplay of these key processes. • As organisms develop, the “reference base” of previous ...


Frontiers (Special Edition 2010) - One Heart. One Hospital, University of Tennessee Medical Center, University of Tennessee Graduate School of Medicine 2010 University of Tennessee, Knoxville

Frontiers (Special Edition 2010) - One Heart. One Hospital, University Of Tennessee Medical Center, University Of Tennessee Graduate School Of Medicine

Frontiers Magazine

No abstract provided.


Program Evaluation For Tdap Immunization Standing Orders In A Birthing Hospital, Helen Crean Taugher DNP 2010 UMass Amherst School of Nursing

Program Evaluation For Tdap Immunization Standing Orders In A Birthing Hospital, Helen Crean Taugher Dnp

Doctor of Nursing Practice (DNP) Projects

Newborn infants are vulnerable to pertussis infections. Although the Advisory Committee on Immunization Practices (ACIP) recommends that babies begin their diphtheria, tetanus and acellular pertussis (DTaP) immunization series at two months of age, the minimum age for administration of the vaccine is six weeks of age (Centers for Disease Control [CDC], 2008). Young infants are at risk for whooping cough infection transmitted from parents, siblings and care-givers during the pre-vaccination period in the first two months of life, particularly pertussis transmitted from their mothers. Since the licensure of adult/adolescent formulations of tetanus, diphtheria and acellular pertussis (Tdap) vaccine in ...


Bully Victim Identification And Intervention Program For School Nurses, Nora Zinan 2010 University of Massachusetts Amherst

Bully Victim Identification And Intervention Program For School Nurses, Nora Zinan

Doctor of Nursing Practice (DNP) Projects

School nurses see bullies and their victims as visitors to the health office with physical and emotional symptoms. Yet school nurses feel unprepared and unqualified to deal with bullying issues. They are not included as team members in the whole school approach to bullying prevention. METHOD: Eleven school nurses from Greenfield, Northampton and the Union #38 School district participated in The Bully Victim Identification and Intervention Program for School Nurses. Participants completed the Perceptions of Bullying Questionnaire (Hendershot, Dake, Price & Larty, 2006) prior to the training, immediately following the training and 1 month after the training. RESULT: All of the ...


Communication And Teamwork Focused Simulation-Based Education For Nursing Students, Jared M. Kutzin 2010 UMass Amherst

Communication And Teamwork Focused Simulation-Based Education For Nursing Students, Jared M. Kutzin

Doctor of Nursing Practice (DNP) Projects

Simulation has become a common teaching method for healthcare providers, including nursing students. Until recently, the focus of simulation for nursing students has been on clinical skills. This study used a compilation survey to determine if knowledge and attitude scores improved in the bachelor degree nursing student after exposure to a simulation-based teamwork and communication training. Participants were 51 students from the senior leadership course of a bachelor’s degree in nursing program at a university in New Jersey. Control participants received normal clinical rotations with faculty led discussions, and intervention participants received a 4-hour simulation, focused on teamwork and ...


Correlates Of Sharing Injection Equipment Among Male Injecting Drug Users In Kathmandu, Nepal, Krishna Poudel, Kalpana Poudel-Tandukar, Junko Yasuoka, Anand Joshi, Masamine Jimba 2010 University of Massachusetts - Amherst

Correlates Of Sharing Injection Equipment Among Male Injecting Drug Users In Kathmandu, Nepal, Krishna Poudel, Kalpana Poudel-Tandukar, Junko Yasuoka, Anand Joshi, Masamine Jimba

College of Nursing Faculty Publication Series

Background: HIV prevalence is high and risky injection practices occur frequently among injecting drug users (IDUs) in Nepal. We explored the correlates of sharing injection equipment (having injected with a needle or syringe previously used by another) among male IDUs in Kathmandu, Nepal. Methods: From August to September 2007, we anonymously interviewed 296 male IDUs in Kathmandu, Nepal, using a structured questionnaire. We performed bivariate and multivariable logistic regression analysis and identified variables associated with sharing injection equipment. Results: Over half (n = 152) of the participants reported injecting drugs with a needle or syringe previously used by another in the ...


The Role Of Employment Status, Work Disruption, Leisure, And Resources In The Mental Health Of Demenita Caregiving Daughters, Lisa Jones Ficker 2010 Wayne State University

The Role Of Employment Status, Work Disruption, Leisure, And Resources In The Mental Health Of Demenita Caregiving Daughters, Lisa Jones Ficker

Wayne State University Dissertations

Employment has been consistently identified as a role strain among dementia caregivers. This study sought to examine the patterns and context of employment and work disruption among dementia caregiving daughters and learn the extent to which work disruption influences mental health through hypothesized reductions in financial resources and leisure activities. This study was a cross-sectional design that extracted data of 486 daughter caregivers from a dataset that gathered information from Caucasian, African American, and Latina dementia caregivers at six research sites across the nation.

Results indicated that caregiving daughters who were employed reported the lowest number of depressive symptoms and ...


The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz 2010 Wayne State University

The Contribution Of Nmda Receptors Within The Central Nucleus Of The Amygdala To The Suppression Of Pain Affect, Catherine Ann Spuz

Wayne State University Dissertations

The amygdala processes stimuli that threaten an individual and organizes the execution of affective behaviors designed to cope with the threat. The prototypical threat to an individual is exposure to a noxious stimulus. The central nucleus of the amygdala (CeA) receives nociceptive afferents and exhibits neuronal activation in response to noxious peripheral stimulation. NMDA receptors within CeA mediate this noxious-evoked neural excitation, and previous studies in the laboratory have shown that blockade of CeA NMDA receptors via the antagonist APV elevates the threshold for noxious tail-shock-induced vocalization afterdischarges (VADs), a validated measure of pain affect in the rat. The present ...


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