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Uncoupling Of Sister Replisomes During Eukaryotic Dna Replication, Hasan Yardimci, Anna B. Loveland, Satoshi Habuchi, Antoine M. van Oijen, Johannes C. Walter 2010 Harvard Medical School

Uncoupling Of Sister Replisomes During Eukaryotic Dna Replication, Hasan Yardimci, Anna B. Loveland, Satoshi Habuchi, Antoine M. Van Oijen, Johannes C. Walter

Faculty of Science, Medicine and Health - Papers: part A

The duplication of eukaryotic genomes involves the replication of DNA from multiple origins of replication. In S phase, two sister replisomes assemble at each active origin, and they replicate DNA in opposite directions. Little is known about the functional relationship between sister replisomes. Some data imply that they travel away from one another and thus function independently. Alternatively, sister replisomes may form a stationary, functional unit that draws parental DNA toward itself. If this "double replisome" model is correct, a constrained DNA molecule should not undergo replication. To test this prediction, lambda DNA was stretched and immobilized at both ends …


Analysis Of Kinetic Intermediates In Single-Particle Dwell-Time Distributions, Daniel L. Floyd, Stephen C. Harrison, Antoine M. van Oijen 2010 Harvard Medical School

Analysis Of Kinetic Intermediates In Single-Particle Dwell-Time Distributions, Daniel L. Floyd, Stephen C. Harrison, Antoine M. Van Oijen

Faculty of Science, Medicine and Health - Papers: part A

Many biological and chemical processes proceed through one or more intermediate steps. Statistical analysis of dwell-time distributions from single molecule trajectories enables the study of intermediate steps that are not directly observable. Here, we discuss the application of the randomness parameter and model fitting in determining the number of steps in a stochastic process. Through simulated examples, we show some of the limitations of these techniques. We discuss how shot noise and heterogeneity among the transition rates of individual steps affect how accurately the number of steps can be determined. Finally, we explore dynamic disorder in multistep reactions and show …


Imaging Spectroscopy Of Vegetation Photosynthetic Activity, Zbynek Malenovky, Michael E. Schaepman, Alexander Damm, Felix Morsdorf 2010 University of Zurich

Imaging Spectroscopy Of Vegetation Photosynthetic Activity, Zbynek Malenovky, Michael E. Schaepman, Alexander Damm, Felix Morsdorf

Faculty of Science, Medicine and Health - Papers: part A

Abstract of paper that was presented at the Symposium GIS Ostrava 2010: GIS meets Remote Sensing and Photogrammetry towards Digital World, 24-27 Janurary, VSB - Technical University of Ostrava campus, the New Hall building, Ostrava, Czech Republic.


Implementing Evidence-Based Practice In Taiwanese Nursing Homes Attitudes And Perceived Barriers And Facilitators, Hui Chen Chang, Cherry Russell, Mairwen Jones 2010 Yuanpei University

Implementing Evidence-Based Practice In Taiwanese Nursing Homes Attitudes And Perceived Barriers And Facilitators, Hui Chen Chang, Cherry Russell, Mairwen Jones

Faculty of Science, Medicine and Health - Papers: part A

To date, there is a paucity of research investigating nurses' perceptions of evidence-based practice (EBP) in nursing homes, especially in non-Western countries. This descriptive, quantitative study investigated attitudes toward and perceived barriers and facilitators to research utilization among 89 Taiwanese RNs. The majority of nurses expressed positive attitudes toward research and EBP. The most frequently cited barriers were related to insufficient authority to change practice, difficulty understanding statistical analyses, and a perceived isolation from knowledgeable colleagues with whom to discuss the research. EBP facilitators included improved access to computers and Internet facilities in the workplace, more effective research training, and …


穴位按壓對護理之家住民便秘成效之研究, Hui Chen Chang, Su-Ching Kuo, Pei Ying Chen, Hui-Wen Chien 2010 Yuanpei University

穴位按壓對護理之家住民便秘成效之研究, Hui Chen Chang, Su-Ching Kuo, Pei Ying Chen, Hui-Wen Chien

Faculty of Science, Medicine and Health - Papers: part A

The purpose of this study is to compare the acupressure program with abdominal massage and laxatives for constipation in elderly nursing home residents. An experimental research design was conducted in two nursing homes in Hsinchu City, Taiwan, with ninety elderly (aged over sixty-five years) nursing home residents who experienced bowel openings less than twice a week.

Subjects were assigned to three groups randomly, one is control group (with laxatives only), and the other two are experimental groups (one with laxatives and abdominal massage and the other with laxatives, acupressure and abdominal massage). The research was performed over 10 days. A …


Sensitivity Of The Female Rat To Olanzapine-Induced Weight Gain - Far From The Clinic?, Katrina Weston-Green, Xu-Feng Huang, Chao Deng 2010 University of Wollongong

Sensitivity Of The Female Rat To Olanzapine-Induced Weight Gain - Far From The Clinic?, Katrina Weston-Green, Xu-Feng Huang, Chao Deng

Faculty of Science, Medicine and Health - Papers: part A

Dear Editor, The recent paper by Chintoh and colleagues (2008) reporting olanzapine-induced dysfunction in glucose metabolism, enhanced visceral fat and reduced locomotor activity in female rats was highly interesting as it illustrated olanzapine’s ability to replicate aspects of metabolic dysfunction in the rodent model in a similar manner to the human scenario. However, contrary to previous reports in the rat and the clinic, the authors reported no change in body weight or food intake following olanzapine treatment, questioning the validity of the rat model.................


Potential Control Of Antipsychotic-Induced Hyperprolactinemia And Obesity In Children And Adolescents By Aripiprazole, J Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng 2010 University of Wollongong

Potential Control Of Antipsychotic-Induced Hyperprolactinemia And Obesity In Children And Adolescents By Aripiprazole, J Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng

Faculty of Science, Medicine and Health - Papers: part A

The paper published in your journal by Migiliardi et al. (2009) reported that increased hyperprolactinemia is a major side-effect of risperidone and olanzapine treatment in children and adolescents. They showed that risperidone could cause 10 times higher prolactin levels than olanzapine treatment in children and adolescents. This was a well-designed study that controlled for dose, gender, and individual differences, as well as response differences to treatment duration (Migliardi et al. 2009). However, another important issue that should be considered, but was not reported in this study, is antipsychotic-induced weight gain/obesity. Clinical data have demonstrated that weight gain is a major …


What Is The Mechanism For Aripiprazole's Effect On Reducing Olanzapine-Associated Obesity?, Chao Deng, J-Z Chen, Changhua Hu, Xu-Feng Huang 2010 University of Wollongong

What Is The Mechanism For Aripiprazole's Effect On Reducing Olanzapine-Associated Obesity?, Chao Deng, J-Z Chen, Changhua Hu, Xu-Feng Huang

Faculty of Science, Medicine and Health - Papers: part A

We read with great interest Henderson and colleagues’ paper in your journal (2009; 29:165–169), which reported that aripiprazole reduced olanzapine-induced overweight/obesity and hyperlipidemia in a 10-week placebo-controlled double-blind crossover study. This and their previous studies, provide a new way for controlling olanzapine- and clozapine-induced weight gain/obesity using another atypical antipsychotic, even without reducing the original olanzapine and clozapine doses, which is important particularly for treatment of refractory schizophrenia patients. ....


Cosmogenic 21ne Analysis Of Individual Detrital Grains: Opportunities And Limitations, Alexandru T. Codilean, Paul Bishop, Trevor B. Hoey, Finlay M. Stuart, Derek Fabel 2010 University of Glasgow

Cosmogenic 21ne Analysis Of Individual Detrital Grains: Opportunities And Limitations, Alexandru T. Codilean, Paul Bishop, Trevor B. Hoey, Finlay M. Stuart, Derek Fabel

Faculty of Science, Medicine and Health - Papers: part A

We use a numerical model describing cosmogenic nuclide acquisition in sediment moving through the upper Gaub River catchment to evaluate the extent to which aspects of source area geomorphology and geomorphological processes can be inferred from frequency distributions of cosmogenic 21Ne (21Nec) concentrations in individual detrital grains. The numerical model predicts the pathways of sediment grains from their source to the outlet of the catchment and calculates the total 21Nec concentration that each grain acquires along its pathway. The model fully accounts for variations in nuclide production due to changes in latitude, altitude and topographic shielding and allows for spatially …


Investigating The Glacial History Of The Northern Sector Of The Cordilleran Ice Sheet With Cosmogenic 10be Concentrations In Quartz, Arjen P. Stroeven, Derek Fabel, Alexandru T. Codilean, Johan Kleman, John J. Clague, Maria Miguens-Rodriguez, Sheng Xu 2010 Stockholm University

Investigating The Glacial History Of The Northern Sector Of The Cordilleran Ice Sheet With Cosmogenic 10be Concentrations In Quartz, Arjen P. Stroeven, Derek Fabel, Alexandru T. Codilean, Johan Kleman, John J. Clague, Maria Miguens-Rodriguez, Sheng Xu

Faculty of Science, Medicine and Health - Papers: part A

Exposure durations of glacial landforms in widely separated areas of central Yukon Territory affected by the northern sector of the Cordilleran Ice Sheet (CIS) and alpine glaciers have been determined using cosmogenic 10Be in quartz. The aim of our research is to test previous reconstructions of glacial history and to begin to address the paucity of chronological control for the lateral and vertical extent of the northern CIS. Chronological evidence for CIS expansion predating the Last Glacial Maximum comes from minimum surface exposure durations of c 100 ka for two bedrock samples within the Reid glacial limit, indicating a possible …


Selection Of Integration Time Intervals For Quartz Osl Decay Curves, Alastair C. Cunningham, Jakob Wallinga 2010 Delft University of Technology

Selection Of Integration Time Intervals For Quartz Osl Decay Curves, Alastair C. Cunningham, Jakob Wallinga

Faculty of Science, Medicine and Health - Papers: part A

In quartz optically stimulated luminescence (OSL) dating protocols, an initial integral of the OSL decay curve is used in the calculation of equivalent dose, once a background integral has been subtracted. Because the OSL signal commonly contains a number of exponentially decaying components, the exact choice of time intervals used for the initial-signal and background integrals determines the composition of the net signal. Here we investigate which combination of time intervals will produce the net signal most dominated by the fast OSL component, while keeping an acceptable level of precision. Using a three-component model of OSL decay, we show that …


A New Late Devonian Brachiopod Fauna From New South Wales, Anthony J. Wright, Jiaxin Yan 2010 University of Wollongong

A New Late Devonian Brachiopod Fauna From New South Wales, Anthony J. Wright, Jiaxin Yan

Faculty of Science, Medicine and Health - Papers: part A

No abstract provided.


Hydroxyl Radicals In The Tropical Troposphere Over The Suriname Rainforest: Airborne Measurements, M Martinez, H Harder, Dagmar Kubistin, M Rudolf, G Eerdekens, H Fischer, T Klupfel, C Gurk, R Konigstedt, U Parchatka, C L. Schiller, A Stickler, J Williams, J Lelieveld 2010 Max Planck Institute for Chemistry

Hydroxyl Radicals In The Tropical Troposphere Over The Suriname Rainforest: Airborne Measurements, M Martinez, H Harder, Dagmar Kubistin, M Rudolf, G Eerdekens, H Fischer, T Klupfel, C Gurk, R Konigstedt, U Parchatka, C L. Schiller, A Stickler, J Williams, J Lelieveld

Faculty of Science, Medicine and Health - Papers: part A

Direct measurements of OH and HO2 over a tropical rainforest were made for the first time during the GABRIEL campaign in October 2005, deploying the custom-built HORUS instrument (HydrOxyl Radical measurement Unit based on fluorescence Spectroscopy), adapted to fly in a Learjet wingpod. Biogenic hydrocarbon emissions were expected to strongly reduce the OH and HO2 mixing ratios as the air is transported from the ocean over the forest. However, surprisingly high mixing ratios of both OH and HO2 were encountered in the boundary layer over the rainforest. The HORUS instrumentation and calibration methods are described in detail and the measurement …


Technical Note: Formal Blind Intercomparison Of Ho2 Measurements In The Atmosphere Simulation Chamber Saphir During The Hoxcomp Campaign, H Fuchs, T Brauers, H -P Dorn, H Harder, R Haseler, A Hofzumahaus, F Holland, Yugo Kanaya, Y Kajii, Dagmar Kubistin, S Lou, M Martinez, K Miyamoto, S Nishida, M Rudolf, E Schlosser, A Wahner, A Yoshino, U Schurath 2010 Forschungszentrum Julich, Gemany

Technical Note: Formal Blind Intercomparison Of Ho2 Measurements In The Atmosphere Simulation Chamber Saphir During The Hoxcomp Campaign, H Fuchs, T Brauers, H -P Dorn, H Harder, R Haseler, A Hofzumahaus, F Holland, Yugo Kanaya, Y Kajii, Dagmar Kubistin, S Lou, M Martinez, K Miyamoto, S Nishida, M Rudolf, E Schlosser, A Wahner, A Yoshino, U Schurath

Faculty of Science, Medicine and Health - Papers: part A

Hydroperoxy radical (HO2) concentrations were measured during the formal blind intercomparison campaign HOxComp carried out in Jülich, Germany, in 2005. Three instruments detected HO2 via chemical conversion to hydroxyl radicals (OH) and subsequent detection of the sum of OH and HO2 by laser induced fluorescence (LIF). All instruments were based on the same detection and calibration scheme. Because measurements by a MIESR instrument failed during the campaign, no absolute reference measurement was available, so that the accuracy of individual instruments could not be addressed. Instruments sampled ambient air for three days and were attached to the atmosphere simulation chamber SAPHIR …


Hydroxyl Radicals In The Tropical Troposphere Over The Suriname Rainforest: Comparison Of Measurements With The Box Model Mecca, Dagmar Kubistin, H Harder, M Martinez, M Rudolf, R Sander, H Bozem, G Eerdekens, H Fischer, C Gurk, T Klupfel, R Konigstedt, U Parchatka, C L. Schiller, A Stickler, D Taraborrelli, J Williams, J Lelieveld 2010 Max Planck Institute for Chemistry

Hydroxyl Radicals In The Tropical Troposphere Over The Suriname Rainforest: Comparison Of Measurements With The Box Model Mecca, Dagmar Kubistin, H Harder, M Martinez, M Rudolf, R Sander, H Bozem, G Eerdekens, H Fischer, C Gurk, T Klupfel, R Konigstedt, U Parchatka, C L. Schiller, A Stickler, D Taraborrelli, J Williams, J Lelieveld

Faculty of Science, Medicine and Health - Papers: part A

As a major source region of the hydroxyl radical OH, the Tropics largely control the oxidation capacity of the atmosphere on a global scale. However, emissions of hydrocarbons from the tropical rainforest that react rapidly with OH can potentially deplete the amount of OH and thereby reduce the oxidation capacity. The airborne GABRIEL field campaign in equatorial South America (Suriname) in October 2005 investigated the influence of the tropical rainforest on the HOx budget (HOx = OH + HO2). The first observations of OH and HO2 over a tropical rainforest are compared to steady state concentrations calculated with the atmospheric …


B Cell-Intrinsic Signaling Through Il-21 Receptor And Stat3 Is Required For Establishing Long-Lived Antibody Responses In Humans, Danielle T. Avery, Elissa K. Deenick, Cindy S. Ma, Santi Suryani, Nicholas Simpson, Gary Y. J Chew, Tyani D. Chan, Umamainthan Palendira, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Sharon Choo, Karl E. Bleasel, Jane Peake, Cecile King, Martyn French, Dan Engelhard, Sami Al-Hajjar, Saleh Al-Muhsen, Klaus Magdorf, Joachim Roesler, Peter D. Arkwright, Pravin Hissaria, D. Sean Riminton, Melanie Wong, Robert Brink, David A. Fulcher, Jean-Laurent Casanova, Matthew C. Cook, Stuart Tangye 2010 Garvan Institute of Medical Research

B Cell-Intrinsic Signaling Through Il-21 Receptor And Stat3 Is Required For Establishing Long-Lived Antibody Responses In Humans, Danielle T. Avery, Elissa K. Deenick, Cindy S. Ma, Santi Suryani, Nicholas Simpson, Gary Y. J Chew, Tyani D. Chan, Umamainthan Palendira, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Sharon Choo, Karl E. Bleasel, Jane Peake, Cecile King, Martyn French, Dan Engelhard, Sami Al-Hajjar, Saleh Al-Muhsen, Klaus Magdorf, Joachim Roesler, Peter D. Arkwright, Pravin Hissaria, D. Sean Riminton, Melanie Wong, Robert Brink, David A. Fulcher, Jean-Laurent Casanova, Matthew C. Cook, Stuart Tangye

Faculty of Science, Medicine and Health - Papers: part A

Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte behavior remain incompletely defined. Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a potent regulator of B cell differentiation. We have studied patients with inactivating mutations in STAT1 or STAT3 to dissect their contribution to B cell function in vivo and in response to IL-21 in vitro. STAT3 mutations dramatically reduced the number of functional, antigen (Ag)-specific memory B cells and abolished the ability of IL-21 to induce naive B cells to …


National Review Of Food Label Law & Policy - Australia, Heather Yeatman 2010 University of Wollongong

National Review Of Food Label Law & Policy - Australia, Heather Yeatman

Faculty of Science, Medicine and Health - Papers: part A

Australia is the first country in the world to undertake a complete review of food label law and policy. This independent Review Panel is charged with examining current policies, standards and laws relevant to food labelling; the policy drivers impacting on demands for food labelling; and the policies and mechanisms that are needed to ensure that government plays its optimum role. Particular areas of nutrition focus include health claims and front of pack labelling. The genesis of the review was Australian governments' commitment to regulatory reform to create a seamless national economy, reduce the regulatory burden, and maintain or increase …


Morpho Tectonic Units Of The Zagros Orogenic Belt, Ne Iraq: A Modern Analogue For Subduction Accretion Processes, Sarmad A. Ali, Brian Jones, Solomon Buckman, Sabah Ismail, Khalid Aswad 2010 University of Wollongong

Morpho Tectonic Units Of The Zagros Orogenic Belt, Ne Iraq: A Modern Analogue For Subduction Accretion Processes, Sarmad A. Ali, Brian Jones, Solomon Buckman, Sabah Ismail, Khalid Aswad

Faculty of Science, Medicine and Health - Papers: part A

The Zagros Mountain Belt extends over more than 1800 km through Iraq and southern Iran in front of the Zagros Mountain chain. It forms the boundary between the Iranian Plateau and the Mesopotamian and Gulf basins (Fig. 1). It can be subdivided geomorphologically into: the High Zagros Belt and the Zagros Simply Folded Belt separated by the High Zagros Fault (Berberian and King, 1981; Falcon, 1974; Stockline, 1968). From a tectonic point of view, however, five zones along the length of the Zagros Orogenic Belt can be distinguished (e.g. Stocklin, 1974, 1986; Falcon, 1974; Sten, 1985; Berberian, 1995): the Zagros …


Influenza Outbreaks During World Youth Day 2008 Mass Gathering, Christopher C. Blyth, Hong Foo, Sebastiaan J. Van Hal, Aeron C. Hurt, Ian G. Barr, Ken McPhie, Paul K. Armstrong, William D. Rawlinson, Vicky Sheppeard, Stephen Conaty, Michael Staff, Dominic E. Dwyer, V Sintchenko, G L. Gilbert, N Komadina, R Shaw, S Adamson, J Fizzell, P M. Fennell, F Ba Alawi, S Corbett, K Weston, G Truman, O Nguyen, J Paterson, S Gabriele, C Moreira, B Forssman, M Cretikos, P Maywood, V Bowden, C Lowbridge, S Williams, M Torres, L Heron 2010 University of Western Australia

Influenza Outbreaks During World Youth Day 2008 Mass Gathering, Christopher C. Blyth, Hong Foo, Sebastiaan J. Van Hal, Aeron C. Hurt, Ian G. Barr, Ken Mcphie, Paul K. Armstrong, William D. Rawlinson, Vicky Sheppeard, Stephen Conaty, Michael Staff, Dominic E. Dwyer, V Sintchenko, G L. Gilbert, N Komadina, R Shaw, S Adamson, J Fizzell, P M. Fennell, F Ba Alawi, S Corbett, K Weston, G Truman, O Nguyen, J Paterson, S Gabriele, C Moreira, B Forssman, M Cretikos, P Maywood, V Bowden, C Lowbridge, S Williams, M Torres, L Heron

Faculty of Science, Medicine and Health - Papers: part A

Influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. An influenza outbreak occurred during World Youth Day in Sydney, Australia, July 2008 (WYD2008). We assessed epidemiologic data and respiratory samples collected from attendees who sought treatment for influenza-like illness at emergency clinics in Sydney during this outbreak. Isolated influenza viruses were compared with seasonal influenza viruses from the 2008 influenza season. From 100 infected attendees, numerous strains were identified: oseltamivir-resistant influenza A (H1N1) viruses, oseltamivir-sensitive influenza A (H1N1) viruses, influenza A (H3N2) viruses, and strains from both influenza B lineages (B/Florida/4/2006-like and B/Malaysia/2506/2004-like). Novel …


Simplification With Fixed-Dose Tenofovir-Emtricitabine Or Abacavir-Lamivudine In Treatment Experienced, Virologically Suppressed Adults With Hiv Infection: Combined Analysis Of Two Randomised, Non-Inferiority Trials Bicombo And Steal, Janaki Amin, E De Lazzari, Sean Emery, Allison Martin, E Martinez, Andrew Carr, J Gatell, David A. Cooper 2010 University of New South Wales

Simplification With Fixed-Dose Tenofovir-Emtricitabine Or Abacavir-Lamivudine In Treatment Experienced, Virologically Suppressed Adults With Hiv Infection: Combined Analysis Of Two Randomised, Non-Inferiority Trials Bicombo And Steal, Janaki Amin, E De Lazzari, Sean Emery, Allison Martin, E Martinez, Andrew Carr, J Gatell, David A. Cooper

Faculty of Science, Medicine and Health - Papers: part A

Background: There is uncertainty about the comparative safety and effi cacy of the fi xed-dose-combination tablets tenofovir 300mg+emtricitabine 200mg (TDF/FTC); and abacavir 600mg+lamivudine 300mg (ABC/3TC). Methods: We used random effects meta-analysis to compare 96 week data for ABC/3TC and TDF/FTC randomised arms from the BICOMBO (n=333) and STEAL (n=357) treatment experienced and virologically suppressed switch studies. Endpoints included: virological failure (VF, repeat plasma HIV RNA >400 copies/mL); mean change to week 96 in CD4 and metabolic parameters; proportion with serious non-AIDS events (SNAEs, retrospectively collected in BICOMBO). We used exact statistics for relative difference in proportions (RD), and ANOVA for …


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