Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, 2009 Bowling Green State University
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Howard Casey Cromwell
Abstract. Perinatal exposure to PCB has been reported to cause a variety of health effects including endocrine disruption, and immunologic, reproductive, neurologic, and behavioral deficits. In the present study, a mixture of two PCB congeners, one non-coplanar (PCB 47) and one coplanar (PCB 77), were administered to young female Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Impact on learning and memory were examined by radial arm maze on postnatal day 24-27. After behavioral tests were completed, the rats were transcardially perfused, and brains were excised. Immunohistochemistry for ER- β was carried out …
Ans Binding Reveals Common Features Of Cytotoxic Amyloid Species, 2009 University of Cambridge
Ans Binding Reveals Common Features Of Cytotoxic Amyloid Species, Benedetta Bolognesi, Janet Kumita, Teresa Barros, Elin Esbjorner, Leila Luheshi, Damian Crowther, Mark Wilson, Christopher Dobson, Giorgio Favrin, Justin Yerbury
Mark R Wilson
Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer's disease. The precise nature of the toxic agents, however, remains still to be established. We show that prefibrillar aggregates of E22G (arctic) variant of the A beta(1-42) peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity. Moreover, we show that this phenomenon is common to other amyloid systems, such as wild-type A beta(1-42), the 159T variant of human lysozyme and an SH3 domain. These findings are …
The Evaluation Of Conservation Practice Placement In The Little River Experimental Watershed Using Geographic Information Systems, 2009 Eastern Kentucky University
The Evaluation Of Conservation Practice Placement In The Little River Experimental Watershed Using Geographic Information Systems, J Settimi, Dana Sullivan, Timothy Strickland
John R. Settimi
The Conservation Effects Assessment Program Watershed Assessment Study is a joint effort between the USDA Natural Resources Conservation Service (NRCS) and the USDA Agricultural Research Service to evaluate the effectiveness of federally funded conservation programs. In response to this initiative, a 26-year history of NRCS conservation practice placement (1980 to 2006) was evaluated for the Little River Experimental Watershed (LREW) in the southeastern coastal plain of Georgia. To accomplish this task, currently available geographic databases were integrated and queried to assess levels of commonly adopted practices and to evaluate factors affecting practice placement. Databases included (1) USDA NRCS Conservation Practice …
Dc Expressing Transgene Foxp3 Are Regulatory Apc, 2009 Howard University
Dc Expressing Transgene Foxp3 Are Regulatory Apc, Michael Lipscomb
Michael Lipscomb
Lifestyle, Anthropometric, And Obesity-Related Physiologic Determinants Of Insulin-Like Growth Factor-1 In The Third National Health And Nutrition Examination Survey (1988-1994).Pdf, 2009 University of Rhode Island
Lifestyle, Anthropometric, And Obesity-Related Physiologic Determinants Of Insulin-Like Growth Factor-1 In The Third National Health And Nutrition Examination Survey (1988-1994).Pdf, Niyati Parekh, Calpurnyia B. Roberts, Maya Vadiveloo, Thanusha Puvananayagam, Jeanine Albu, Grace L. Lu-Yao
Maya Vadiveloo
The Intellectual Property Landscape For Ips Cells, 2009 University of California, Hastings
The Intellectual Property Landscape For Ips Cells, Robin C. Feldman
Robin C Feldman
Nomenclatural Changes For Some Grasses In California And The Muhlenbergia Clade (Poaceae), 2009 Humboldt State University
Nomenclatural Changes For Some Grasses In California And The Muhlenbergia Clade (Poaceae), James Payne Smith Jr.
James Payne Smith
No abstract provided.
Contributions Of Francisella Tularensis Subsp. Novicida Chitinases And Sec Secretion System To Biofilm Formation On Chitin, 2009 Stanford University School of Medicine
Contributions Of Francisella Tularensis Subsp. Novicida Chitinases And Sec Secretion System To Biofilm Formation On Chitin, Jeffrey J. Margolis, Sahar H. El-Etr, Lydia-Marie Joubert, Emily Moore, Richard Robinson, Amy Rasley, Alfred M. Spormann, Denise M. Monack
Jeffrey Margolis
Ganaxolone Suppression Of Behavioral And Electrographic Seizures In The Mouse Amygdala Kindling Model, 2009 University of California - Davis
Ganaxolone Suppression Of Behavioral And Electrographic Seizures In The Mouse Amygdala Kindling Model, Doodipala S. Reddy, Michael A. Rogawski
Michael A. Rogawski
Ganaxolone (3alpha-hydroxy-3alpha-methyl-5alpha-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABA-A receptors, may represent a new treatment approach for epilepsy. Here we demonstrate that pretreatment with ganaxolone (1.25—20 mg/kg, s.c.) causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested. The ED50 for suppression of behavioral seizures was 6.6 mg/kg. The seizure suppression produced by ganaxolone was comparable to that of clonazepam (ED50, 0.1 mg/kg, s.c.). To the extent that amygdala kindling represents a model of mesial temporal lobe epilepsy, …
Indigenous Ectosymbiotic Bacteria Associated With Diverse Hydrothermal Vent Invertebrates, 2009 Occidental College
Indigenous Ectosymbiotic Bacteria Associated With Diverse Hydrothermal Vent Invertebrates, Shana K. Goffredi
Shana Goffredi
Symbioses involving bacteria and invertebrates contribute to the biological diversity and high productivity of both aquatic and terrestrial environments. Well-known examples from chemosynthetic deep-sea hydrothermal vent environments involve ectosymbiotic microbes associated with the external surfaces of marine invertebrates. Some of these ectosymbioses confer protection or defence from predators or the environment itself, some are nutritional in nature, and many still are of unknown function. Several recently discovered hydrothermal vent invertebrates, including two populations of yeti crab (Kiwa spp.), a limpet (Symmetromphalus aff. hageni), and the scaly-foot snail (as yet undescribed), support a consortium of diverse bacteria. Comparisons of these ectosymbioses …
Dispersal Of Stable Flies (Diptera: Muscidae) From Larval Developmental Sites., 2009 University of Minnesota - Twin Cities
Dispersal Of Stable Flies (Diptera: Muscidae) From Larval Developmental Sites., David B. Taylor, Roger D. Moon, John B. Campbell, Dennis R. Berkebile, Philip J. Scholl, Alberto B. Broce, Jerome A. Hogsette
David B. Taylor
Seven mark-recapture studies were conducted over 3 yr to assess dispersal of newly emerging adult stable flies, Stomoxys calcitrans L., from larval development sites in a mixed agricultural environment in northeastern Nebraska. Infested hay debris piles were marked by dusting their surfaces with fluorescent pigments, adults were captured with surrounding grids of Alsynite sticky traps, and specimens were dissected to determine feeding histories and reproductive age. Distances and directions of 3,889 marked specimens indicated males and females dispersed equally and in all directions. Midguts of males and females were equally likely to contain blood-meal remnants. Percentage with blood remnants and …
Criterion Iv: Social And Economic Indicators Of Rangeland Sustainability, 2009 Utah State University
Criterion Iv: Social And Economic Indicators Of Rangeland Sustainability, Mark W. Brunson, Daniel W. Mccollum, Louis E. Swanson, John A. Tanaka, Aaron J. Harp, L. Allen Torell, H. Theodore Heintz Jr.
John A Tanaka
3hsds1和17hsds7基因5'上游区转录活性研究.Pdf, 2009 China Agricultural University
3hsds1和17hsds7基因5'上游区转录活性研究.Pdf, Xinxing Dong, Yi Xin, Ying Bai, Yunzhou Yang, Jibin Zhang, Meiying Fang, Gang Chen
Jibin Zhang
Functional Organization Of A Neural Network For Aversive Olfactory Learning In Caenorhabditis Elegans, 2009 Harvard University
Functional Organization Of A Neural Network For Aversive Olfactory Learning In Caenorhabditis Elegans, H Ha, M Hendricks, Y Shen, C V. Gabel, Christopher Fang-Yen, Y Qin, D Colon-Ramos, K Shen, A D.T. Samuel
Christopher Fang-Yen
No abstract provided.
Toward Genuine Rodent Welfare: Response To Reviewer Comments, 2009 Humane Society Institute for Science and Policy
Toward Genuine Rodent Welfare: Response To Reviewer Comments, Jonathan P. Balcombe
Jonathan Balcombe, Ph.D.
No abstract provided.
Interference With Histidyl-Trna Synthetase By A Crispr Spacer Sequence As A Factor In The Evolution Of Pelobacter Carbinolicus, 2009 University of Massachusetts - Amherst
Interference With Histidyl-Trna Synthetase By A Crispr Spacer Sequence As A Factor In The Evolution Of Pelobacter Carbinolicus, Derek Lovley, Muktak Aklujkar
Muktak Aklujkar
BACKGROUND: Pelobacter carbinolicus, a bacterium of the family Geobacteraceae, cannot reduce Fe(III) directly or produce electricity like its relatives. How P. carbinolicus evolved is an intriguing problem. The genome of P. carbinolicus contains clustered regularly interspaced short palindromic repeats (CRISPR) separated by unique spacer sequences, which recent studies have shown to produce RNA molecules that interfere with genes containing identical sequences. RESULTS: CRISPR spacer #1, which matches a sequence within hisS, the histidyl-tRNA synthetase gene of P. carbinolicus, was shown to be expressed. Phylogenetic analysis and genetics demonstrated that a gene paralogous to hisS in the genomes of Geobacteraceae is …
Synthetic Genome: Now That We’Re Creators, What Should We Create?, 2009 Wesleyan University
Synthetic Genome: Now That We’Re Creators, What Should We Create?, Frederick M. Cohan
Frederick M. Cohan
No abstract provided.
The Ecology Of Speciation In Bacillus, 2009 Wesleyan University
The Ecology Of Speciation In Bacillus, Nora Connor, Johannes Sikorski, Alejandro P. Rooney, Sarah Kopac, Alexander F. Koeppel, Andrew Burger, Scott G. Cole, Elizabeth B. Perry, Danny Krizanc, Nicholas C. Field, Michele Slaton, Frederick M. Cohan
Frederick M. Cohan
No abstract provided.
The Genome Of Geobacter Bemidjiensis, Exemplar For The Subsurface Clade Of Geobacter Species That Predominate In Fe(Iii)-Reducing Subsurface Enviorments, 2009 University of Massachusetts - Amherst
The Genome Of Geobacter Bemidjiensis, Exemplar For The Subsurface Clade Of Geobacter Species That Predominate In Fe(Iii)-Reducing Subsurface Enviorments, Derek Lovley, Muktak Aklujkar, Nealson D. Young, Dawn Holmes, Milind Chavan, Carla Risso, Hajnalka E. Kiss, Cliff S. Han, Miriam L. Land
Carla Risso
BACKGROUND: Geobacter species in a phylogenetic cluster known as subsurface clade 1 are often the predominant microorganisms in subsurface environments in which Fe(III) reduction is the primary electron-accepting process. Geobacter bemidjiensis, a member of this clade, was isolated from hydrocarbon-contaminated subsurface sediments in Bemidji, Minnesota, and is closely related to Geobacter species found to be abundant at other subsurface sites. This study examines whether there are significant differences in the metabolism and physiology of G. bemidjiensis compared to non-subsurface Geobacter species. RESULTS: Annotation of the genome sequence of G. bemidjiensis indicates several differences in metabolism compared to previously sequenced non-subsurface …
Cortical Underconnectivity Coupled With Preserved Visuospatial Cognition In Autism: Evidence From An Fmri Study Of An Embedded Figures Task, 2009 Carnegie Mellon University
Cortical Underconnectivity Coupled With Preserved Visuospatial Cognition In Autism: Evidence From An Fmri Study Of An Embedded Figures Task, Saudamini Damarla, Timothy A. Keller, Rajesh K. Kana, Vladimir L. Cherkassky, Diane L. Williams, Nancy J. Minshew, Marcel Adam Just
Marcel Adam Just
No abstract provided.