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Lipid Pathway Alterations In Parkinson's Disease Primary Visual Cortex, Danni Cheng, Andrew M. Jenner, Guanghou Shui, Wei Fun Cheong, Todd W. Mitchell, Jessica Nealon, Woojin Scott Kim, H Mccann, Markus R. Wenk, Glenda Halliday, Brett Garner

Faculty of Science - Papers (Archive)

Background: We present a lipidomics analysis of human Parkinson’s disease tissues. We have focused on the primary visual cortex, a region that is devoid of pathological changes and Lewy bodies; and two additional regions, the amygdala and anterior cingulate cortex which contain Lewy bodies at different disease stages but do not have as severe degeneration as the substantia nigra. Methodology/Principal Findings: Using liquid chromatography mass spectrometry lipidomics techniques for an initial screen of 200 lipid species, significant changes in 79 sphingolipid, glycerophospholipid and cholesterol species were detected in the visual cortex of Parkinson’s disease patients (n = 10) compared to …