Social and Behavioral Sciences Commons^™

Overcoming Disparities In The Treatment Of Alzheimer’S Disease, Christian Gamboa, Tribhuvan Lanka, Elaine Flowers, Nayarith Lopez

Rowan-Virtua Research Day

Background: Deaths due to Alzheimer’s have been increasing at an exponential rate for the last 24 years, with an astounding 145% increase between the years 2000-2024. Early detection is key to slowing down the rate of decline. Unfortunately, Latino and African American individuals delay seeking care, which predisposes them to worse outcomes. To date, socioeconomic limitations are the main factors leading to delayed care in Latino and African American communities. A service project was developed with the aim of addressing limitations that result in delays to seeking care within Latino and African American communities.

Methods: A systematic review of available …

Gamma-Aminobutyric Acid (Gaba) Neurons And Perineuronal Nets (Pnn) In The Monodelphis Domestica And Relevance To Psychiatric Disorders, Jatziry Z. Luna Escobedo, Mariela Garcia, John L. Vandeberg, Mario Gil

Research Symposium

Background/ Purpose: Gamma-aminobutyric acid (GABA) is an amino acid that serves as the central nervous system’s (CNS) main inhibitory neurotransmitter. By inhibiting nerve transmission, it works to lower neuronal excitability. Altered GABA levels have been associated with a variety of psychiatric disorders, for example Epilepsies, Parkinson’s Disease, and Schizophrenia. Perineuronal nets (PNN) are extracellular molecules that are released by neurons and glial cells that modulate many neuronal and glial functions by encapsulating the inhibitory cells and neurites. Altered PNN levels serve as a potential trigger to synaptic imbalance. The purpose of this study is to quantify and analyze the presence, …

Apoe Risk Disclosure: A Review Of Positive And Negative Outcome, Stacey Rowcliffe

Dissertations

Two of this century’s most significant healthcare challenges are Alzheimer’s disease and mild cognitive impairment, with 40 million people suffering from the diseases. In fact, a conservative estimate projects that both conditions will double every 20 years until 2050. Alzheimer’s disease involves memory impairment, disorientation, confusion, and various problematic behaviors. Presently, no prevention method or cure has been discovered for Alzheimer’s. Mild cognitive impairment typically includes problems with memory, language, thinking, and judgment beyond those typical of one’s age. Usually, these symptoms do not interfere with daily activities but do not improve and have been linked with a risk of …

Systemic Growth Factor Increases As A Result Of Exercise May Reduce Alzheimer's Disease Risk In Midlife Mice And Humans, Amanda Hewes

Electronic Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder with insidious onset and slow progression. AD research has traditionally been based on neuronal and glial dysfunction due to hallmark beta-amyloid and tau pathologies. Although literature supports an association between AD and cardiovascular disease and/or cardiovascular risk factors, vascular dysfunction as an etiology of AD has been overlooked. Cardiovascular risk factors have been associated with both cardiovascular and cerebrovascular disease in midlife individuals, an age at which modifiable risk factor management may be the most beneficial. Up to half of AD cases worldwide and in the USA are attributable to modifiable risk factors. …

An Exploration Into The Design Of A Portable Music Player For People With Alzheimer’S And Dementia, Jaxon V. Silva

Liberal Arts and Engineering Studies

An exploration into the design of a portable music player for people with Alzheimer's and dementia.

Effects Of Music Exposure On Autobiographical Memory In Alzheimer's Patients: A Systematic Review And Meta-Analysis, Gregory Vance

Honors Theses

The progression of Alzheimer’s disease is primarily characterized by a loss of memory concerning past events, as well as a lack in ability to create new memories. While this spans across many subsets of memory, such as recognition, recall, and autobiographical memory, there seems to be a lesser impact on musical memory in those with Alzheimer’s. Multiple studies have suggested that exposure to music and introduction of music therapy can even improve other aspects of memory in Alzheimer’s patients. This systematic review and meta-analysis sought to examine the relationship between music exposure and autobiographical memory specifically. A pool of electronic …

Intergenerational And Intragenerational Connections Within A University Art Museum Program For People With Dementia, Sujal Manohar, Jessica Kay Ruhle

International Journal of Lifelong Learning in Art Education

This visual essay highlights the impacts of the Nasher Museum of Art’s Reflections program, which engages people with dementia (PWD) and their care partners through interactive art museum tours. This program’s conversation-based tours with built-in time to socialize are designed to foster intergenerational and intragenerational connections between PWD and museum gallery guides, PWD and care partners, and between PWD. Discussions about artwork are visitor-driven and encourage lifelong learning among participants. Anecdotal feedback from Reflections participants and gallery guides confirms the value of relationship building, improving quality of life for PWD.

By fostering community and strong connections, Reflections programs help reduce …

Interdependence With Our Most Forgetful Elders: Alzheimer's In The Anthropocene, Christine Heller

Electronic Theses and Dissertations

This dissertation uses autoethnography and critical psychological and philosophical theories to explore what people with Alzheimer’s disease teach us about being, forgetting, and dying in the Anthropocene. The author collected personal memory data from her lived experience of being with her mother while she had Alzheimer’s disease, and organized these memories into a series of vignettes. Each vignette was analyzed with critical psychological and philosophical theories to illuminate intersubjective themes of denial, things, ancestors, place, dying, and time. These themes connected the personal to the epochal and articulated the wisdom that our most forgetful elders can share in the Anthropocene, …

Alternative Treatment Method For Dementia In The Southwest Region Of Arizona, Angela May Lynch

Walden Dissertations and Doctoral Studies

The purpose of this qualitative professional administrative study was to explore anddevelop a new innovative method of treatment for dementia clients using reminiscence therapy (RT) in a proposed 24-hour care village in Tucson, Arizona. In this proposed 24- hour care village, patients would remain in an environment conducive to a safe and normal lifestyle. This administrative study is a qualitative study using grounded theory and sources of evidence included current research, personal interviews, and articles. Data were collected from interviews with 10 administrators of memory care facilities in Tucson, Arizona, to determine if existing administrative staff were aware of RT …

The Relationship Between Neuropsychological Functioning, Biomarker Av-1451, And Subjective Memory Impairment In A Cognitively Normal Sample, Amberrose Reale-Caldwell

Dissertations

Mild cognitive impairment (MCI) is often a prodromal stage for Alzheimer’s disease (AD) development, with those diagnosed with MCI at increased risk for developing AD. The present study aimed to provide data to support a prodromal stage of MCI via analysis utilizing the neuropsychological domain of memory, subjective memory impairment (SMI), and the PET tau biomarker, AV-1451. It was hypothesized that individuals with SMI would differ significantly from participants without SMI (nSMI) on measures of memory and level of tau binding in the entorhinal cortices and the hippocampi. It was further hypothesized that differences in memory would be mediated by …

The Effects Of A Dementia Simulation Experience On Attitudes Towards People With Dementia, Micah Huckabee

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: The neurodegenerative effects of dementia resulting in cognitive and behavioral impairments is plausibly one of the reasons for a societal stigma towards individuals with dementia. Societal stigmas are associated with decreased life satisfaction, depressive symptoms, and decreased psychological well-being for stigmatized individuals. In an effort to improve attitudes towards individuals with dementia, this study utilized a dementia simulation to measure attitudinal changes after a dementia simulation. Methods: There were 33 participants in this study (13 male and 20 female) between the ages of 18 and 25. Participants completed a Dementia Attitudes Scale (DAS) survey, and then they dressed in …

Introduction To Special Issue: Dementia And Music, Andrea R. Halpern, Isabelle Peretz, Lola L. Cuddy

Andrea Halpern

This special issue follows two previous special issues on music and neurological disorders (April 2008, Volume 23/Issue 4 and April 2010, Volume 25/Issue 4). Like its predecessors, the issue presents studies employing a patient-based approach to music perception, cognition, and emotion. Whereas the earlier issues dealt with acquired and congenital disorders and impairments, the present issue focuses on dementia, primarily on its most common form, Alzheimer's disease (AD).

Co-Localization Patterns Of Aquaporin-4 With Amyloid Beta And Cd68 In Alzheimer's Disease And Cerebrovascular Disease, Anthony Bryan Crum

Theses and Dissertations

Aquaporin-4 (AQP4) is a key component in maintaining proper glymphatic flow. In recent years, the glymphatic system has been discovered and approached as a major factor in amyloid plaque clearance in Alzheimer's disease. This study examines the depolarization of AQP4 from the astrocytic endfeet and subsequent co-localization with amyloid plaques in the hippocampus and subiculum. Results show a significant pattern of co-localization in advanced Alzheimer's disease, as well as increases in AQP4 in cerebrovascular disease. This pattern shows AQP4 should be approached as a promising therapeutic area in future research.

Communicative Behaviors Elicited By Leisure Activities In Memory Care Units, Tarynn Clune

Honors Projects

A wide variety of leisure activities used in reminiscence care have been studied for their merits in terms of preventing cognitive decline, and increasing quality of life; however, little is known about what different types have to offer in terms of communicative opportunities. Communication with peers is imperative for quality of life, and is crucial for maintenance of relationships between the person with dementia (PWD) and their loved ones. As a result of this importance, an exploration of communication elicited by different activities facilitated in a unit was conducted. The communication explored in this study was solely vocal, and included …

Facilitating Environmental Enrichment In Senior Care Activities With Professional Development, Celia Mary Ross

Walden Dissertations and Doctoral Studies

There is little known about the current state of professional development and continuing education practices for empowering activity professionals to better enhance environmental enrichment in long term care. The purpose of this qualitative study was to explore the activity professional's perceived role and best strategies for professional development to enrich the long-term care environment. The study used social cognitive theory as its theoretical framework to develop research questions focused on the views of activity professionals concerning professional development and continuing education to support care for long-term care residents. Using a narrative approach, 9 activity professionals were recruited through networking at …

Use Of A Music And Memory Program By Caregivers Of Persons With Dementia, Barbara Mendez Campos

Honors Undergraduate Theses

Although use of personal music devices by persons with dementia and their caregivers is now widespread, there is limited literature concerning music and memory’s effects on caregivers for persons with dementia. Caregivers were provided an iPod by two respite agencies and were encouraged to use it with their care recipient. A mailed survey of 50 caregivers who received an IPod explored: (a) associations between use of an iPod and caregiver self-efficacy, burden, and care recipient functional abilities, and; (b) if the method of presenting the music playlist was associated with use of the iPod. Associations were examined for 10 complete …

Participation In Active And Passive Music Interventions By Individuals With Alzheimer's Disease And Related Dementias: Effects On Agitation, Robert J. Prattini

LSU Doctoral Dissertations

The ability of music to produce calming effects on us is well documented, and its use is becoming an increasingly accepted intervention with populations displaying agitated and disruptive behaviors, such as people with Alzheimer’s disease (AD) or other dementias. One reason for its widespread use is because research has demonstrated music’s efficacy in reducing agitation, and consequently disruptive behaviors, in those with AD. Prior studies on music’s effects on agitation in older people with AD have utilized either recorded music used passively, or active sessions with a music therapist or musicians, but none have compared the effects of each type …

Novel Advances In Alzheimer's Disease, Jacob P. Naumann

The Downtown Review

Alzheimer’s disease, the most common form of dementia in adults, is a progressive degenerative neurological disease that affects memory, cognition, and behavior. Dr. Alois Alzheimer discovered and diagnosed the irreversible disease in 1906 after documenting the famous case of Auguste Deter.¹ Since the discovery of the disease, numerous advances have made it possible to not only better understand the causal factors, but also to improve the medical diagnosis and preventative measures that healthcare providers can implement. For the first time since 1984, the National Institute on Aging (NIAA) and the Alzheimer’s Association (AA) proposed and published new diagnostic guideline …

Improving The Experiences Of Informal And Formal Alzheimer's Disease And Dementias Caregivers, Roxroy Anthony Reid

Walden Dissertations and Doctoral Studies

Informal and formal caregivers of persons with Alzheimer's disease and related dementias (ADRD) encounter a more difficult and unique set of challenges than do caregivers of individuals with general disabilities. If adequate caregiver supports are not provided, caregivers may experience increased strain as the disease progresses, increasing the likelihood of unnecessary institutionalization of their care recipients and increasing the cost to the public. Using rational choice theory and political systems theory, the purpose of this study was to differentiate between the phenomenological experiences of formal and informal caregivers of ADRD patients. The overall research was a qualitative design that used …

Predictors Of Physician Use Of The New Nia Alzheimer's Assessment Protocols, Richard Norman Schultz

Walden Dissertations and Doctoral Studies

Consensus is lacking on early diagnostic criteria and the exact symptoms of Alzheimer's disease (AD). A new, in-office test may help physicians detect the early symptoms of AD, based upon new National Institute of Aging (NIA) criteria. However, a gap exists in knowledge regarding physicians' current use or intent to use the new protocols. Choreographing the descriptive AD terminology in the Diagnostic and Statistical Manual of Mental Disorders IV-TR and the International Classification of Diseases (ICD-10) is recommended. Thus, the purpose of this study was to understand possible contributing factors to physician's use or intent to use of the new …

Alzheimer’S In America: Effective Physical Activity Methods For Brain Health Reviewed, Royale Cannon, Laurel M. Pritchard

McNair Poster Presentations

The alarming rise in rates of Alzheimer’s disease indicates that there is an immediate need for a solution. According to the Centers for Disease Control and Prevention (2014) Alzheimer’s is currently the sixth leading cause of death in the United States. Over 400,000 new cases are diagnosed each year and these numbers are only expected to rise (Centers for Disease Control, [CDC] 2014). One out of nine people are living with the disease and 84,000 people succumb to this disease every year in America; currently there is no cure or direct treatment plan for the disease (Alzheimer’s Association, [AA] 2010; …

Differential Effects Of Alzheimer's Disease And Huntington's Disease On The Performance Of Mental Rotation, Tara T. Lineweaver, David P. Salmon, Mark W. Bondi, Jody Corey-Bloom

Tara T. Lineweaver

he ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD. Additional analyses showed that these unique patterns of performance were not attributable to different speed/accuracy trade-off sensitivities. This double dissociation suggests that …

Con: Are We Ready To Translate Alzheimer's Disease-Modifying Therapies To People With Down Syndrome?, Elizabeth Head, Frederick A. Schmitt

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Adults with Down syndrome develop Alzheimer's disease neuropathology in an age-dependent manner. This unique feature provides an opportunity to test interventions targeted for prevention of Alzheimer's disease neuropathology and dementia in Down syndrome.

DISCUSSION: In considering clinical trial designs, however, there are several challenges that we believe will be critical to examine further. These include: accuracy in dementia, mild cognitive impairment and preclinical Alzheimer's disease diagnoses in Down syndrome; clinical trial outcome measures appropriate for individuals with Down syndrome; in vivo imaging outcome measures (and practical considerations); and contributions of medical co-morbidities to disease progression. Also, when studies are …

The Social Environment, Apoe-E4, And Dementia: The Social Environment As A Moderating Factor Among Individuals Genetically Predisposed To Develop Dementia, Judith L. Poey

Graduate Doctoral Dissertations

Many studies have shown a relationship between the APOE-e4 allele and dementia, as well as a relationship between the social environment and dementia. However, relatively little investigation into the potential moderating effect of the social environment on the relationship between the APOE-e4 allele and cognitive well-being has been reported. Further, studies that did examine these relationships typically have employed clinical populations, along with regional and non-U.S. samples. This study contributed to the research literature, in part, by using the first U.S. nationally representative sample of older adults that included clinical diagnosis of cognition and dementia (Aging, Demographics, and Memory Study …

Neuropsychological Correlates Of Anosognosia In Mci And Dementia, Krystle Dina Barrera

Loma Linda University Electronic Theses, Dissertations & Projects

Anosognosia is a general term used to describe a lack of awareness of a disability and is well documented in various disorders associated with neurological compromise. While anosognosia is well documented as part and parcel to Alzheimer's dementia, less research has focused on determining the presence of anosognosia in what has come to be viewed as the subclinical precursor to dementia, mild cognitive impairment. In addition, a number of different methodologies and instruments are employed in quantifying and assessing anosognosia in various populations, which make comparison across studies and diagnoses difficult. Research commonly employs a paradigm that uses the discrepancy …

Relationship Between Occupational Complexity And Dementia Risk In Late-Life: A Population Study, Daylee Rose Greene

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

According to cognitive reserve theory, challenging and/or stimulating cognitive activities can build a theoretical reserve, which may lead to a delay in the clinical expression of dementia and/or Alzheimer's disease. These cognitively stimulating activities are thought to build cognitive strategies and neural pathways that are more efficient, enabling the individual to live symptom-free for a longer period of time. One mechanism through which cognitive reserve can be built is by participating in an occupation high in cognitive complexity. When individuals hold an occupation that is high in complexity, they may build their cognitive reserve in such a manner as to …

Functional Correlates Of Verbal Working Memory In Healthy Aging And Early Alzheimer's Disease, Michael Adam Sugarman

Wayne State University Theses

Deficits in the working memory system are common in patients diagnosed with Alzheimer's disease (AD). However, little is known regarding the neurobiological basis of this impairment. The current study examined the neurobiological functional correlates of the working memory system in early AD patients and cognitively intact control participants using a word list repetition task performed during positron emission tomography (PET). Compared to a reading control task, both the AD and control groups utilized a network of parietal, frontal, and cerebellar regions while completing the word rehearsal task. However, control participants displayed greater activation in all regions, especially in the parietal …

Introduction To Special Issue: Dementia And Music, Andrea R. Halpern, Isabelle Peretz, Lola L. Cuddy

Faculty Journal Articles

This special issue follows two previous special issues on music and neurological disorders (April 2008, Volume 23/Issue 4 and April 2010, Volume 25/Issue 4). Like its predecessors, the issue presents studies employing a patient-based approach to music perception, cognition, and emotion. Whereas the earlier issues dealt with acquired and congenital disorders and impairments, the present issue focuses on dementia, primarily on its most common form, Alzheimer's disease (AD).

Psychometric Re-Evaluation Of The Spiritual Support Scale, Angela M. Bowman

LSU Master's Theses

Informal caregivers provide a substantial amount of emotional, financial, physical, and social support to their loved ones with Alzheimer’s disease. Alzheimer’s caregivers often report immense levels of burden, which are associated with the demands of their caregiving duties. Caregivers mediate this burden through various means of coping, including spiritual support. Individuals who successfully manage the negative stressors related to Alzheimer’s caregiving are often highly resilient. The purpose of this study was to re-evaluate the psychometric properties of the Spiritual Support Scale among a sample of Alzheimer’s caregivers. The Spiritual Support Scale was initially utilized to measure spiritual coping among a …

Quantitative Template For Subtyping Primary Progressive Aphasia, Marsel Mesulam, Christina Wieneke, Emily Rogalski, Derin J. Cobia, Cynthia Thompson, Sandra Weintraub

Faculty Publications

Objective—To provide a quantitative algorithm for classifying primary progressive aphasia (PPA) into agrammatic (PPA-G), semantic (PPA-S) and logopenic (PPA-L) variants, each of which is known to have a different probability of association with Alzheimer’s disease (AD) versus frontotemporal lobar degeneration (FTLD).

Design—Prospectively and consecutively enrolled 16 PPA patients tested with neuropsychological instruments and magnetic resonance imaging (MRI).

Setting—University medical center. Participants—PPA patients recruited nationally in the USA as part of a longitudinal study.

Results—A two-dimensional template, reflecting performance on tests of syntax (Northwestern Anagram Test) and lexical semantics (Peabody Picture Vocabulary Test), classified all 16 patients in concordance with a …