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Diet Composition And Insulin Action In Animals Models, Leonard Storlien, J A. Higgins, T C. Thomas, John Brown, Hongqin Wang, Xu-Feng Huang, Paul Else

Faculty of Social Sciences - Papers (Archive)

Critical insights into the etiology of insulin resistance have been gained by the use of animal models where insulin action has been modulated by strictly controlled dietary interventions not possible in human studies. Overall, the literature has moved from a focus on macronutrient proportions to understanding the unique effects of individual subtypes of fats, carbohydrates and proteins. Substantial evidence has now accumulated for a major role of dietary fat subtypes in insulin action. Intake of saturated fats is strongly linked to development of obesity and insulin resistance, while that of polyunsaturated fats (PUFAs) is not. This is consistent with observations …