Social and Behavioral Sciences Commons^™

Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl

Faculty of Health and Behavioural Sciences - Papers (Archive)

Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to the development of psychosis-like symptoms after cannabis use. To test whether the schizophrenia candidate gene neuregulin 1 (NRG1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response to repeated Δ⁹-tetrahydrocannabinol (THC, 10 mg/kg i.p. for 21 d starting on post-natal day 31). During treatment and 48 h after treatment withdrawal, we assessed several behavioural parameters relevant to schizophrenia. After behavioural testing we measured autoradiographic …

Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch

Faculty of Science - Papers (Archive)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for the familial, …

A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson

Faculty of Science - Papers (Archive)

Direct heating of a metal-organic framework provides a simple, controllable way of effecting a covalent post-synthetic modification. Herein we report that an allyloxy-tagged zinc metal-organic framework undergoes a thermally-promoted aromatic Claisen rearrangement through which the framework connectivity and porosity are maintained.

Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett

Faculty of Science - Papers (Archive)

Collaborative and cross-disciplinary research by a group of artists and scientists in an Australian rural setting generates data and ideas that form the basis of a wider understanding of the ramifications of global warming and cooling within the local, regional and national community. The work is viewed as an initial educational platform that will allow the public to see and understand the complexities of climate-based research.

Musculoskeletal And Estrogen Changes During The Adolescent Growth Spurt In Girls, Catherine Y. Wild, Julie R. Steele, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

Introduction: The adolescent growth spurt is associated with rapid growth and hormonal changes, thought to contribute to the increased anterior cruciate ligament injury risk in girls. However, relatively little is known about these musculoskeletal and estrogen changes during the growth spurt in girls. Purpose: To investigate the longitudinal changes in estrogen as well as anterior knee laxity and lower limb strength and flexibility throughout the adolescent growth spurt in girls. Methods: Thirty-three healthy girls, age 10-13 yr, in Tanner stage II and 4-6 months from their peak height velocity were recruited. Participants were tested up to four times during the …

Direct Evidence For Encoding Of Motion Streaks In Human Visual Cortex, Deborah M. Apthorp, D. Samuel Schwarzkopf, C. Kaul, B. Bahrami, David Alais, G. Rees

Faculty of Health and Behavioural Sciences - Papers (Archive)

Temporal integration in the visual system causes fast-moving objects to generate static, oriented traces (‘motion streaks’), which could be used to help judge direction of motion. While human psychophysics and single-unit studies in non-human primates are consistent with this hypothesis, direct neural evidence from the human cortex is still lacking. First, we provide psychophysical evidence that faster and slower motions are processed by distinct neural mechanisms: faster motion raised human perceptual thresholds for static orientations parallel to the direction of motion, whereas slower motion raised thresholds for orthogonal orientations. We then used functional magnetic resonance imaging to measure brain activity …

Bryophyte Species Composition Over Moisture Gradients In The Windmill Islands, East Antarctica: Development Of A Baseline For Monitoring Climate Change Impacts, J Wasley, S A. Robinson, J D. Turnbull, D H. King, W Wanek, M Popp

Faculty of Science - Papers (Archive)

Extreme environmental conditions prevail on the Antarctic continent and limit plant diversity to cryptogamic communities, dominated by bryophytes and lichens. Even small abiotic shifts, associated with climate change, are likely to have pronounced impacts on these communities that currently exist at their physiological limit of survival. Changes to moisture availability, due to precipitation shifts or alterations to permanent snow reserves, will most likely cause greatest impact. In order to establish a baseline for determining the effect of climate change on continental Antarctic terrestrial communities and to better understand bryophyte species distributions in relation to moisture in a floristically important Antarctic …

The Isolation Of Bioactive Flavonoids From Jacaranda Obtusifolia H. B. K. Ssp. Rhombifolia (G. F. W. Meijer) Gentry, Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen G. Pyne, Mary J. Garson, Boonsom Liawruangrath

Faculty of Science - Papers (Archive)

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).

Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke

Faculty of Science - Papers (Archive)

Translocating birds to a new area of habitat to restore or supplement depleted populations may pose a significant threat to the translocated individuals. While for many species, translocated individuals appear to move larger distances than resident animals, species with poor dispersal capacity may be restricted in movements and translocation methods may need to accommodate differences in movements to ensure success. In this study, designed to provide insights to inform our broader programme of translocations in New South Wales, Australia, we investigated post-release movements in the endangered, semi-flightless Eastern Bristlebird (Dasyornis brachypterus). We predicted that movements would be minimal, with few …

Manufacturing On The Move? Beyond The High Dollar In The Debate About Making Things In Australia - The Case Of The Australian Surfboard Industry - Ausccer Discussion Paper No. 2012/2, Andrew Warren, Chris Gibson

Faculty of Science - Papers (Archive)

In October 2011 surfboard manufacturer BASE abruptly closed its factory on the Gold Coast resulting in the direct loss of 50 jobs. A few days later, nearby D’Arcy Surfboards also announced it was shedding workers and downsizing from a state-of-the art purpose built factory into a backyard workshop. Each business exported surfboards internationally and employed some of Australia’s best known surfboard-makers. The troubles facing these workshops added to those brewing at the very same in Australia’s steel, aluminium, automotive and garment industries. With renewed public debate and media commentary on the future of manufacturing, we now face a crisis in …

Process-Evaluation Of Tropospheric Humidity Simulated By General Circulation Models Using Water Vapor Isotopologues: 1. Comparison Between Models And Observations, Camille Risi, David Noone, John Worden, Christian Frankenberg, Gabriele Stiller, Michael Kiefer, Bernd Funke, Kaley Walker, Peter Bernath, Matthias Schneider, Debra Wunch, Vanessa Sherlock, Nicholas M. Deutscher, David W. Griffith, Paul O. Wennberg, Kimberly Strong, Dan Smale, Emmanuel Mahieu, Sabine Barthlott, Frank Hase, Omar Garcia, Justus Notholt, Thorsten Warneke, Geoffrey Toon, David Sayres, Sandrine Bony, Jeonghoon Lee, Derek Brown, Ryu Uemura, Christophe Sturm

Faculty of Science - Papers (Archive)

[1] The goal of this study is to determine how H2O and HDO measurements in water vapor can be used to detect and diagnose biases in the representation of processes controlling tropospheric humidity in atmospheric general circulation models (GCMs). We analyze a large number of isotopic data sets (four satellite, sixteen ground-based remote-sensing, five surface in situ and three aircraft data sets) that are sensitive to different altitudes throughout the free troposphere. Despite significant differences between data sets, we identify some observed HDO/H2O characteristics that are robust across data sets and that can be used to evaluate models. We evaluate …

The Role Of Streptokinase As A Virulence Determinant Of Streptococcus Pyogenes - Potential For Therapeutic Targeting, Jason D. Mcarthur, Simon M. Cook, Carola Venturini, Mark J. Walker

Faculty of Science - Papers (Archive)

Streptococcus pyogenes is a major human pathogen responsible for numerous diseases ranging from uncomplicated skin and throat infections to severe, life threatening invasive disease such as necrotising fasciitis and streptococcal toxic shock syndrome. These severe invasive infections progress rapidly and produce high rates of morbidity and mortality despite the implementation of aggressive treatment plans. The activation of plasminogen and the acquisition of plasmin activity at the bacterial cell surface is critical for the invasive pathogenesis of this organism. To facilitate this process, S. pyogenes secrete streptokinase, a potent plasminogen activating protein. Here, we describe the role of streptokinase in invasive …

Seed Bank Persistence And Climate Change, Mark K. J Ooi

Faculty of Science - Papers (Archive)

"The strong mechanistic relationship between climatic factors and seed dormancy and germination suggests that forecast climatic changes will significantly affect seed bank persistence. This review focuses on the potential impact of changing temperature, rainfall and fire regimes on the longevity of long-term persistent seed-banks. Currently, there are few studies investigating the mechanistic responses of demographic processes, such as seed-bank dynamics, to forecast climate change. However, from the work that has been published, several key points have been highlighted. First, increased air temperatures will produce significantly higher soil temperatures in open and sparsely vegetated habitats. Some evidence shows that this could …

Evaluation Of The Evidence Between Consumption Of Refined Grains And Health Outcomes, Peter G. Williams

Faculty of Health and Behavioural Sciences - Papers (Archive)

This review evaluates the available evidence on the relationship between consumption of refined grains and health outcomes. A total of 135 relevant articles were identified from database searches of studies published between 2000 and 2010. The great majority found no associations between the intake of refined grain foods and cardiovascular disease, diabetes, weight gain or overall mortality. A few studies found that very high intakes might be associated with some types of cancers, but at moderate levels of consumption the risks were not significant. The totality of evidence shows that consumption of up to 50% of all grain foods as …

Australian Adolescents' Compliance With Sun Protection Behaviours During Summer: The Importance Of The School Context, Melinda Williams, Sandra C. Jones, Peter Caputi, Donald Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Adolescents exhibit significantly lower sun protection behaviours than adults in Australia. While many studies have assessed the sun protection behaviours of adolescents during summer, few studies have explored the differences in sun protection behaviours of adolescents across key contexts relevant to adolescents during summer—notably school time, weekends and school holidays. Greater understanding of differences in behaviours across these contexts provides more detailed explanations of the nature of adolescent ultraviolet exposure and thereby facilitates improved targeting of interventions for this segment whose behaviour is considered hard to change. In this study, we explore the differences in self-reported, habitual, sun protection behaviours …

Fish Consumption And Chd Mortality: An Updated Meta-Analysis Of Seventeen Cohort Studies, Jusheng Zheng, Tao Huang, Yinghua Yu, Xiaojie Hu, Bin Yang, Duo Li

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects. Design A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity. Setting PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study. Subjects Seventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified. Results …

Reflection Impulsivity In Adolescent Cannabis Users: A Comparison With Alcohol-Using And Non-Substance-Using Adolescents, Nadia Solowij, Katy A. Jones, Megan E. Rozman, Sasha M. Davis, Joseph Ciarrochi, Patrick C. L Heaven, Nicole Pesa, Dan I. Lubman, Murat Yucel

Faculty of Health and Behavioural Sciences - Papers (Archive)

Rationale Reflection impulsivity-a failure to gather and evaluate information before making a decision-is a critical component of risk-taking and substance use behaviours, which are highly prevalent during adolescence. Objectives and methods The Information Sampling Test was used to assess reflection impulsivity in 175 adolescents (mean age 18.3, range 16.5-20; 55% female)-48 cannabis users (2.3 years use, 10.8 days/month), 65 alcohol users, and 62 non-substance-using controls-recruited from a longitudinal cohort and from the general community and matched for education and IQ. Cannabis and alcohol users were matched on levels of alcohol consumption. Results Cannabis users sampled to the lowest degree of …

Online Advertising: Examining The Content And Messages Within Websites Targeted At Children, Lisa Kervin, Sandra C. Jones, Jessica Mantei

Faculty of Health and Behavioural Sciences - Papers (Archive)

It is recognised that from a young age children spend considerable portions of their leisure time on the Internet. In Australia a number of child-targeted magazines have associated websites, which have high and ever-increasing readership. We do not yet know the impact of this medium upon children. Overt advertising is evident on webpages, but so too are hidden advertisements in the written text, images and games. This material usually does not comply with existing broadcasting codes of practice for mainstream advertising. This article examines the instances of overt and covert advertisements for food within three websites monitored over a 12-month …

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Faculty of Health and Behavioural Sciences - Papers (Archive)

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …

Circumventing The Who Code? An Observational Study, Nina J. Berry, Sandra C. Jones, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background This study compares the formula milk advertisements that appeared in parenting magazines published in two countries that have enacted measures to restrict the advertising of infant formula products in response to the international code with two that have not. Methods Content analysis was used to compare the type and frequency of formula milk advertisements that appeared in parenting magazines collected from the USA, Canada, the UK and Australia during 2007, and to examine whether there was a relationship between these frequencies and advertising regulations. Findings Advertisements that promoted formula products or brands occurred in all of the magazines sampled …

The Association Between Job Demands/Control And Health In Employed Parents: The Mediating Role Of Work-To-Family Interference And Enhancement, Christopher A. Magee, Natalie Stefanic, Peter Caputi, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

"This paper examined whether work-to-family interference (WFI) and work-to-family enhancement (WFE) mediated the association between job demands/control and self-reported mental and physical health. Data were from the Household, Income and Labor Dynamics in Australia survey and included 1,404 Australian adults aged 18-64 years at baseline; 820 participants provided data at three time points (baseline, 12-month follow-up, and 24-month follow-up). Self-report questionnaires assessed mental and physical health, WFI and WFE, and job demands/control. Mediation analyzes performed on the longitudinal data indicated that WFI mediated the relationships between job demands/control and self-reported mental and physical health. The findings have implications for improving …

Food Toxicity And Safety, Peter Williams

Faculty of Health and Behavioural Sciences - Papers (Archive)

Key Points

• Despite the many potential health risks associated with foods, in practice the degree of risk associated with the modern food supply is extremely low.

• By far the most important hazards of significance are those from biological agents: pathogenic bacteria, viruses, fungi and a few toxic seafoods.

• Trends to larger-scale production, longer distribution chains in the food supply, increased eating away from the home and the emergence of new pathogens means foodborne illness continues to be a significant public health issue.

• The assessment of the safety of food additives is led internationally by JECFA, but …

Healthy Beginnings Trial Phase 2 Study: Follow-Up And Cost-Effectiveness Analysis, Li Ming Wen, Louise A. Baur, Chris Rissel, Vicki Flood, Judy M. Simpson, Alison Hayes, Louise L. Hardy, Karen Wardle

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: In 2007, we commenced the Healthy Beginnings Trial (HBT) Phase 1 study, which is the first randomised controlled trial (RCT) to test the effectiveness of an early childhood obesity intervention in children aged up to 2 years. The results were promising with significant improvements in infant feeding practices and a lower mean body mass index (BMI). The aims of this proposed Phase 2 study are to determine if the early intervention will lead to a lower mean BMI, lower screen time, improved dietary behaviours and demonstrated costeffectiveness of the intervention, in children aged 3½ and 5 years. Methods/design: In …

Independent Effects Of Local And Global Binocular Disparity On The Perceived Convexity Of Stereoscopically Presented Faces In Scenes, Harold Matthews, Harold Hill, Stephen Palmisano

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Noise , Beno Groothoff, Faioh Coh

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

A Hangover And A One-Night Stand: Alcohol And Risky Sexual Behaviour Among Female Students At An Australian University, Heidi Gilchrist, Kylie Smith, Christopher A. Magee, Sandra Jones

Faculty of Health and Behavioural Sciences - Papers (Archive)

There is a growing body of research in Australia exploring the alcohol consumption behaviours of young people and the attendant health and social risks associated with excessive use of alcohol (Chikritzhs et al. 2003; Mancina-Pena & Tyson 2007). A number of studies from countries such as the United States and New Zealand indicate that university students tend to drink at riskier levels than the broader population (see for example Wechsler et al. 1994; Kypri, Stephenson & Langley 2005; Wechsler & Nelson 2008). Data from Australia are limited, although the few studies that have been conducted suggest that Australian university students …

The Impact Of Complex Survey Design On Prevalence Estimates Of Intakes Of Food Groups In The Australian National Children's Nutrition And Physical Activity Survey, Sandy Burden, Yasmine Probst, David G. Steel, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Barriers And Enablers To Implementation Of A New Zealand-Wide Guideline For Assessment And Management Of Cardiovascular Risk In Primary Health Care: A Template Analysis, Ann Mckillop, Jackie Crisp, Kenneth Walsh

Faculty of Health and Behavioural Sciences - Papers (Archive)

Aim: The aim of this study was to identify the enablers and barriers to guideline implementation in a primary healthcare setting by employing the Promoting Action on Research Implementation in Health Services (PARIHS) framework as a template for data analysis and interpretation. Background: The use of clinical practice guidelines is pivotal to improving health outcomes. However, the implementation of guidelines into practice is complex, unpredictable, and, in spite of much investigation, remains resistant to explanation of what works and why. Optimising the enablers and minimising the barriers to implementation of a guideline for reducing cardiovascular disease risk has the potential …

Vection During Conflicting Multisensory Information About The Axis, Magnitude And Direction Of Self-Motion, April Ash, Stephen Palmisano

Faculty of Health and Behavioural Sciences - Papers (Archive)

We examined the vection induced by consistent and conflicting multisensory information about self-motion. Observers viewed displays simulating constant-velocity self-motion in depth while physically oscillating their heads left ^ right or back ^ forth in time with a metronome. Their tracked head movements were either ignored or incorporated directly into the self-motion display (as an added simulated self-acceleration). When this head oscillation was updated into displays, sensory conflict was generated by simulating oscillation along: (i) an orthogonal axis to the head movement; or (ii) the same axis, but in a non-ecological direction. Simulated head oscillation always produced stronger vection than `no …

The Link Between Dietary Glycemic Index And Nutrient Adequacy, Jimmy Chun Yu Louie, Annette E. Buyken, Jennie C. Brand-Miller, Victoria M. Flood

Faculty of Health and Behavioural Sciences - Papers (Archive)

BACKGROUND: Low-glycemic index (low-GI) diets may be less nutritious because of limited food choices. Alternately, high-GI diets could be less healthful because of a higher intake of refined carbohydrate. OBJECTIVE: The objective was to investigate the association between dietary GI, intakes of carbohydrates from high-GI (CHO(high GI)) and low-GI (CHO(low GI)) sources, and the risk of nutrient inadequacy in children and adolescents. DESIGN: Children, aged 2-16 y, who provided 2 plausible 24-h recalls in a national survey were included (n = 4140). The ORs of not meeting the Australian Nutrient Reference Values (NRVs) were calculated by logistic regression. RESULTS: Subjects …