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Full-Text Articles in Social and Behavioral Sciences
Roles Of Rifampicin In Drug-Drug Interactions: Underlying Molecular Mechanisms Involving Nuclear Receptor Pxr, Jiezhong Chen, Kenneth Raymond
Roles Of Rifampicin In Drug-Drug Interactions: Underlying Molecular Mechanisms Involving Nuclear Receptor Pxr, Jiezhong Chen, Kenneth Raymond
Faculty of Social Sciences - Papers (Archive)
Rifampicin, an important drug in the treatment of tuberculosis, is used extensively despite its broad effects on drug-drug interactions, creating serious problems. The clinical importance of such interactions includes autoinduction leading to suboptimal or failed treatment. The concomitantly administered effects of rifampicin on other drugs can result in their altered metabolism or transportation that are metabolised by cytochromes P450 or transported by p-glycoprotein in the gastrointestinal tract and liver. This review paper summarises recent findings with emphases on the molecular mechanisms used to explain these broad drug-drug interactions. In general, rifampicin can act on a pattern: rifampicin activates the nuclear …
Online Forum Discussion Interactions As An Indicator Of Student Community, Shane Dawson
Online Forum Discussion Interactions As An Indicator Of Student Community, Shane Dawson
Faculty of Social Sciences - Papers (Archive)
Given the current diversity of communication tools at an educator's disposal, what role (if any) does the discussion forum play in the development of a strong sense of community among students? This study sought to investigate the relationship between discussion forum interaction and perceived student sense of community. The results of the study demonstrate that while mere quantity of discussion forum postings is not an indicator of community development, a significant relationship is observed when contributions are codified into the various discussion interaction types (learner -learner; learner - content; system), An implication emerging from these findings is the ability for …