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Polymorphisms Of Cx3cr1 And Cxcr6 Receptors In Relation To Haart Therapy Of Hiv Type 1 Patients, Andreas M. Passam, George Sourvinos, Elias Krambovitis, Spyridon Miyakis, Nikolaos G. Stavrianeas, Ioannis Zagoreos, Demetrios A. Spandidos

Faculty of Science, Medicine and Health - Papers: part A

The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX3CR1-V249I, and CX3CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/ul for patients with baseline CD4 below 200 cells/ul and above 500 cells/ul for patients with baseline CD4 between 200 and 500 cells/ul, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX3CR1-249I or CX3CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response.