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Clusterin Protein Diversity In The Primate Eye, Paul Wong, Bruce A. Pfeffer, Steven L. Bernstein, Michelle L. Chambers, Gerald J. Chader, Zahra F. Zakeri, Yan-Q Wu, Mark Wilson, S Patricia Becerra

Faculty of Science, Medicine and Health - Papers: part A

Purpose: The clusterin gene encodes a multi-functional protein that has been identified in different tissues, including a number of different eye tissues, primarily in the mouse and to a much lesser extent in humans. Clusterin has been implicated in a number of cellular processes such as lipid transport, membrane integrity, apoptosis, and neurodegeneration, all of which could be important to the biology of the eye. In the current communication, we provide data that confirms the expression of clusterin in a number of different human eye tissues and establishes the expression profile of this gene in monkey derived eye tissues. The …