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Adipose Depletion And Apoptosis Induced By Trans-10, Cis-12 Conjugated Linoleic Acid In Mice, Kimberly M. Hargrave, Changlong Li, Brett J. Meyer, Stephen D. Kachman, Diane L. Hartzell, Mary Anne Della-Fera, Jess Miner, Clifton A. Baile
Adipose Depletion And Apoptosis Induced By Trans-10, Cis-12 Conjugated Linoleic Acid In Mice, Kimberly M. Hargrave, Changlong Li, Brett J. Meyer, Stephen D. Kachman, Diane L. Hartzell, Mary Anne Della-Fera, Jess Miner, Clifton A. Baile
Department of Statistics: Faculty Publications
Objective: To compare the effectiveness of a conjugated linoleic acid (CLA) isomer mixture (mCLA) with each main isomer [trans-10,cis-12 CLA (CLA10,12) and cis-9,trans-11 CLA (CLA9,11)] in causing body lipid loss and adipose tissue apoptosis.
Research Methods and Procedures: Mice selected over 16 generations for high (MH) or low (ML) energy expenditure and a control group (MC) were fed diets containing either soy oil or soy oil plus mCLA, CLA10,12, or CLA9,11 for 5 days in one study and 14 days in a second study.
Results: Mice fed mCLA or CLA10,12 had less body lipid (p _ 0.05), smaller retroperitoneal …