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Articles 1 - 5 of 5

Full-Text Articles in Biostatistics

Aging And The Public Health Impact Of Dementia, Ron Brookmeyer, Claudia Kawas Nov 2001

Aging And The Public Health Impact Of Dementia, Ron Brookmeyer, Claudia Kawas

Ron Brookmeyer

No abstract provided.


Parametric And Nonparametric Methods For Understanding The Relationship Between Carcinogen-Induced Dna Adduct Levels In Distal And Proximal Regions Of The Colon., Jeffrey S. Morris, Naisyin Wang, Joanne R. Lupton, Robert S. Chapkin, Nancy D. Turner, Mee-Young Hong, Raymond J. Carroll Sep 2001

Parametric And Nonparametric Methods For Understanding The Relationship Between Carcinogen-Induced Dna Adduct Levels In Distal And Proximal Regions Of The Colon., Jeffrey S. Morris, Naisyin Wang, Joanne R. Lupton, Robert S. Chapkin, Nancy D. Turner, Mee-Young Hong, Raymond J. Carroll

Jeffrey S. Morris

An important problem in studying the etiology of colon cancer is understanding the relationship between DNA adduct levels (broadly, DNA damage) in cells within colonic crypts in distal and proximal parts of the colon, following treatment with a carcinogen and different types of diet. In particular, it is important to understand whether rats who have elevated adduct levels in particular positions in distal region crypts also have elevated levels in the same positions of the crypts in proximal regions, and whether this relationship depends on diet. We cast this problem as estimating the correlation function of two responses as a …


Transforming Self-Rated Health And The Sf-36 Scales To Include Death And Improve Interpretability, Paula Diehr Jul 2001

Transforming Self-Rated Health And The Sf-36 Scales To Include Death And Improve Interpretability, Paula Diehr

Paula Diehr

BACKGROUND: Most measures of health-related quality of life are undefined for people who die. Longitudinal analyses are often limited to a healthier cohort (survivors) that cannot be identified prospectively, and that may have had little change in health. OBJECTIVE: To develop and evaluate methods to transform a single self-rated health item (excellent to poor; EVGGFP) and the physical component score of the SF-36 (PCS) to new variables that include a defensible value for death. METHODS: Using longitudinal data from two large studies of older adults, health variables were transformed to the probability of being healthy in the future, conditional on …


Probabilities Of Transition Among Health States For Older Adults, Paula Diehr Jan 2001

Probabilities Of Transition Among Health States For Older Adults, Paula Diehr

Paula Diehr

GOAL: To estimate the probabilities of transition among self-rated health states for older adults, and examine how they vary by age and sex. METHODS: We used self-rated health (excellent, very good, good, fair, poor, dead) collected in two longitudinal studies of older adults (mean age 75) to estimate the probability of transition in 2 years. We used the estimates to project future health for selected cohorts. FINDINGS: These older adults were most likely to be in the same health state 2 years later, but a substantial proportion changed in both directions. Transition probabilities varied by initial health state, age and …


Patterns Of Self-Rated Health In Older Adults Before And After Sentinel Events, Paula Diehr Jan 2001

Patterns Of Self-Rated Health In Older Adults Before And After Sentinel Events, Paula Diehr

Paula Diehr

OBJECTIVES: To describe and compare patterns of change in self-rated health for older adults before death and before and after stroke, myocardial infarction, congestive heart failure, cardiac procedure, hospital admission for cancer, and hip fracture. DESIGN: "Event cohort," measuring time in months before and after the event. SETTING: Four U.S. communities. PARTICIPANTS: 5888 participants in the Cardiovascular Health Study (CHS), sampled from Medicare rolls and followed up to 8 years. Mean age at baseline was 73. MEASUREMENTS: Self-rated health, including a category for death, assessed at 6-month intervals, and ascertainment of events. METHODS: We examined the percentage that was healthy …