Physics Commons^™

Modulations Of Lipid Membranes Caused By Antimicrobial Agents And Helix 0 Of Endophilin, Nawal Kishore Khadka

USF Tampa Graduate Theses and Dissertations

Understanding the cellular membrane interaction with membrane active biomolecules and antimicrobial agents provides an insight in their working mechanism. Here, we studied the effect of antimicrobial agents; a recently developed peptidomimetics E107-3 and colistin as well as the N-terminal helix H0, of Endophilin A1 on the lipid bilayer.

It is important to discern the interaction mechanism of antimicrobial peptides with lipid membranes in battling multidrug resistant bacterial pathogens. We study the modification of structural and mechanical properties with a recently reported peptidomimetic on lipid bilayer. The compound referred to as E107-3 is synthesized based on the acylated reduced amide scaffold …

Water And Salt At The Lipid-Solvent Interface, James M. Kruczek

USF Tampa Graduate Theses and Dissertations

Lipid bilayers are important biological structures. The changes in bilayer properties are induced by the composition of the bilayer as well as the solvent. In this work, we study the effects of different molecular makeups of lipids and ionic solvents with molecular dynamics simulations to determine their effect on the bilayer interface. In particular, we look at how different carbon chain bindings affect water viscosity at the interface and allow for a less permeable bilayer. Additionally, we examine the changes to the bilayer due to the presence of the most biologically relevant salt ions. Lastly, we show how the pharmacological …