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31p Nmr Study Of Gtp-Cation Interactions, Zhiyan Song, Destiny L. Allen, Olarongbe Olubajo, Chellu S. Chetty
31p Nmr Study Of Gtp-Cation Interactions, Zhiyan Song, Destiny L. Allen, Olarongbe Olubajo, Chellu S. Chetty
Georgia Journal of Science
Guanosine 5'-triphosphate (GTP) plays a pivotal role in many biological processes. The interactions of cations with GTP are essential to the stabilization of this nucleotide and the regulation of its functions. In this study, we present solution 31P NMR data on GTP samples in varied salt concentrations or pHs. From chemical shifts and T1 , T2 relaxations, it is concluded that the interaction strengths of cations with GTP are in the order of Ca2+ > Mg2+ > Li+ > Na+ for the cations, and in the order of beta > gamma > alpha for the phosphate groups. An …