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Full-Text Articles in Physical Sciences and Mathematics
Application Of Genomics To Regulatory Ecological Risk Assessments For Pesticides, Steven P. Bradbury, Sigmund J. Degitz, Robert A. Hoke, Richard Brennan, Lee Ferguson, Rebecca Klaper, Laszlo Orban, David Spurgeon, Susan Tilton
Application Of Genomics To Regulatory Ecological Risk Assessments For Pesticides, Steven P. Bradbury, Sigmund J. Degitz, Robert A. Hoke, Richard Brennan, Lee Ferguson, Rebecca Klaper, Laszlo Orban, David Spurgeon, Susan Tilton
Steven P. Bradbury
Substantial advances in human health and ecological risk assessment have been achieved by the risk assessment community; however, challenges remain, such as providing credible scientific information on a timely, efficient basis to support decisions for industrial chemicals and pesticides. Current risk assessment data generation requirements-including animal welfare concerns and the volume, appropriateness, and cost of required data-and the large number of chemicals requiring evaluation are a challenge confronting the chemical industry, national and international regulatory agencies, and associated stakeholders (Bradbury et al. 2004). The lack of hazard data for many chemicals and the need to improve the efficiency and quality …
Toxic Responses Of The Fish Nervous System, Steven P. Bradbury, Richard W. Carlson, Tala R. Henry, Stephanie Padilla, John Cowden
Toxic Responses Of The Fish Nervous System, Steven P. Bradbury, Richard W. Carlson, Tala R. Henry, Stephanie Padilla, John Cowden
Steven P. Bradbury
Few of the approximately 70,000 chemicals on the Toxic Substances Control Act inventory or the 1000 to 1600 new chemicals introduced each year in the United States have been tested for neurotoxicity to support risk assessments (NRC, 1992), even though it is estimated that 5 to 10% of them are likely to be neurotoxic. Neurotoxicity has been defined as adverse effects of physical, biological, or chemical agents on the structure or function of the nervous system in developing or adult organisms (Philbert et al., 2000). From a human health risk assessment perspective, the potential for neurotoxic effects associated with synthetic …