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Full-Text Articles in Physical Sciences and Mathematics
Reactivity Profiles Of Ligands Of Mammalian Retinoic Acid Receptors: A Preliminary Corepa Analysis, Steven P. Bradbury, G. T. Ankley, O. G. Mekenyan, V. . Kamenska, P. K. Schmieder
Reactivity Profiles Of Ligands Of Mammalian Retinoic Acid Receptors: A Preliminary Corepa Analysis, Steven P. Bradbury, G. T. Ankley, O. G. Mekenyan, V. . Kamenska, P. K. Schmieder
Steven P. Bradbury
Retinoic acid and associated derivatives comprise a class of endogenous hormones that bind to and activate different families of retinoic acid receptors (RARs, RXRs), and control many aspects of vertebrate development. Identification of potential RAR and RXR ligands is of interest both from a pharmaceutical and toxicological perspective. The recently developed COREPA (COmmon REactivity PAttern) algorithm was used to establish reactivity profiles for a limited data set of retinoid receptor ligands in terms of activation of three RARs (a, b, g) and an RXR (a). Conformational analysis of a training set of retinoids and related analogues in terms of thermodynamic …
Narrowing Historical Uncertainty: Probabilistic Classification Of Ambiguously Identified Tree Species In Historical Forest Survey Data, David J. Mladenoff, Sally E. Dahir, Eric V. Nordheim, Lisa A. Schulte, Glenn G. Guntenspergen
Narrowing Historical Uncertainty: Probabilistic Classification Of Ambiguously Identified Tree Species In Historical Forest Survey Data, David J. Mladenoff, Sally E. Dahir, Eric V. Nordheim, Lisa A. Schulte, Glenn G. Guntenspergen
Lisa A. Schulte Moore
Historical data have increasingly become appreciated for insight into the past conditions of ecosystems. Uses of such data include assessing the extent of ecosystem change; deriving ecological baselines for management, restoration, and modeling; and assessing the importance of past conditions on the composition and function of current systems. One historical data set of this type is the Public Land Survey (PLS) of the United States General Land Office, which contains data on multiple tree species, sizes, and distances recorded at each survey point, located at half-mile (0.8-km) intervals on a 1-mi (1.6 km) grid. This survey method was begun in …