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Articles 1 - 20 of 20
Full-Text Articles in Physical Sciences and Mathematics
Poliomyelitis Virus Vs Smallpox: An Ordinary Differential Equation Model Comparison, Kate Mcgough
Poliomyelitis Virus Vs Smallpox: An Ordinary Differential Equation Model Comparison, Kate Mcgough
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah
Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah
Chemistry: Faculty Publications and Other Works
SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …
Ecological Risk Assessment For The Temperate Demersal Elasmobranch Resource, Department Of Primary Industries And Regional Development, Western Australia
Ecological Risk Assessment For The Temperate Demersal Elasmobranch Resource, Department Of Primary Industries And Regional Development, Western Australia
Fisheries research reports
No abstract provided.
2021 Assessment Of The Status Of The West Coast Demersal Scalefifish Resource, David Fairclough, E. A. Fisher, Sybrand Alex Hesp, Ainslie Denham, Rachel Marks
2021 Assessment Of The Status Of The West Coast Demersal Scalefifish Resource, David Fairclough, E. A. Fisher, Sybrand Alex Hesp, Ainslie Denham, Rachel Marks
Fisheries research reports
No abstract provided.
Otoliths Of South-Western Australian Fish: A Photographic Catalogue, Chris Dowling, Kim Smith, Elain Lek, Joshua Brown
Otoliths Of South-Western Australian Fish: A Photographic Catalogue, Chris Dowling, Kim Smith, Elain Lek, Joshua Brown
Fisheries research reports
No abstract provided.
Squid And Cuttlefish Resources Of Western Australia, Daniel Yeoh, Danielle J. Johnston Phd, David C. Harris
Squid And Cuttlefish Resources Of Western Australia, Daniel Yeoh, Danielle J. Johnston Phd, David C. Harris
Fisheries research reports
No abstract provided.
Covid-19: A One Health Issue, Karen Gruszynski
Covid-19: A One Health Issue, Karen Gruszynski
Cumberland Mountain Naturalist
COVID-19 has very rapidly become part of modern societal lexicon as the disease highlights the importance understanding zoonotic diseases and the impact they can have on human life. With a 177million human cases and 3.82million deaths globally at the time of this publication, the "One Health" nature of the disease has had a lasting impact across the planet. As the disease spread rapidly, it highlighted the dissemination of information through social media and other sources. With this in mind, Dr. Gary Vroegindewey, Director for One Health at LMU-CVM, put forth the idea to have students collect and summarize information about …
Spring 2021
Scientia
From the Dean: A Decade of Purpose and Progress; Lab Notes: Alumna Wins Gordon Bell Special Prize, New Scholarships, Vaccination Site Volunteers; Women in Science Lecture, National Institutes of Health Grants, "Unequal Cities" Research; All Hands on Deck: Inspired pandemic approaches showcase interdisciplinary acumen in action; Unlocking Potential: Christopher Beasley thinks psychology is key to academic transformation for the formerly incarcerated; Puzzle Master: Bridget Tenner goes to pieces solving problems in cutting-edge mathematics
Lexicographic Sensitivity Functions For Nonsmooth Models In Mathematical Biology, Matthew D. Ackley
Lexicographic Sensitivity Functions For Nonsmooth Models In Mathematical Biology, Matthew D. Ackley
Electronic Theses and Dissertations
Systems of ordinary differential equations (ODEs) may be used to model a wide variety of real-world phenomena in biology and engineering. Classical sensitivity theory is well-established and concerns itself with quantifying the responsiveness of such models to changes in parameter values. By performing a sensitivity analysis, a variety of insights can be gained into a model (and hence, the real-world system that it represents); in particular, the information gained can uncover a system's most important aspects, for use in design, control or optimization of the system. However, while the results of such analysis are desirable, the approach that classical theory …
Media Analysis Of Coverage Of Environmental Issues In The Midst Of A Pandemic, Alexandria N. Miller, Lucia A. Bolles
Media Analysis Of Coverage Of Environmental Issues In The Midst Of A Pandemic, Alexandria N. Miller, Lucia A. Bolles
Thinking Matters Symposium
This research aimed to answer the question “has the coronavirus impacted the print media’s coverage of important environmental issues?” The research analyzed 2 different print newspapers - The New York Times and the Wall Street Journal - to determine if there was a change in coverage of environmental news as the coronavirus spread in the US. Data for stories published in the first four days of every month from March through September was compiled for 2019 and 2020. Our findings showed a 78.85% decrease in coverage of environmental issues between 2019 and 2020 when stories related to the coronavirus pandemic …
P14: Emerging Role Of Pharmacists In Treatment And Vaccination For Covid-19, Dwaynie Bacon Jr, Man Ha, Dr. Mandal
P14: Emerging Role Of Pharmacists In Treatment And Vaccination For Covid-19, Dwaynie Bacon Jr, Man Ha, Dr. Mandal
Annual Research Symposium
No abstract provided.
Simulated Contact Tracing Of Covid-19 Propagation At Kutztown University For Fall 2020, Dale E. Parson
Simulated Contact Tracing Of Covid-19 Propagation At Kutztown University For Fall 2020, Dale E. Parson
Computer Science and Information Technology Faculty
From mid-May through August 2020 the author designed, built, revised, and analyzed resulting data from two simulation programs for virtual contact tracing of COVID-19 infection propagation at Kutztown University in the fall 2020 semester. The first was command-line driven and non-graphical, with results distributed to faculty and administrators on May 28. The second was a three-dimensional interactive graphical simulation, distributed to faculty, administrators, and the public as a narrated video via YouTube on July 16. The algorithm is an adaptation of spreading activation as used in theoretical psychology and artificial intelligence research since the 1970s. It propagates discrete, probable infections …
Flattening The Curve: The Effects Of Intervention Strategies During Covid-19, Kelly A. Reagan, Rachel J. Pryor, Gonzalo M. Bearman, David M. Chan
Flattening The Curve: The Effects Of Intervention Strategies During Covid-19, Kelly A. Reagan, Rachel J. Pryor, Gonzalo M. Bearman, David M. Chan
Spora: A Journal of Biomathematics
COVID-19 has plagued countries worldwide due to its infectious nature. Social distancing and the use of personal protective equipment (PPE) are two main strategies employed to prevent its spread. A SIR model with a time-dependent transmission rate is implemented to examine the effect of social distancing and PPE use in hospitals. These strategies’ effect on the size and timing of the peak number of infectious individuals are examined as well as the total number of individuals infected by the epidemic. The effect on the epidemic of when social distancing is relaxed is also examined. Overall, social distancing was shown to …
Long-Term Dynamics Of The Kidney Disease Epidemic Among Hiv-Infected Individuals, Heather Gudaz, Henry A. Ogu, Elissa J. Schwartz
Long-Term Dynamics Of The Kidney Disease Epidemic Among Hiv-Infected Individuals, Heather Gudaz, Henry A. Ogu, Elissa J. Schwartz
Spora: A Journal of Biomathematics
One of many risks facing HIV+ individuals is the development of kidney dysfunction and end stage kidney disease (ESKD). A differential equation-based mathematical model was developed to assess the impact of antiretroviral therapy on the progression to kidney disease and on reducing mortality due to kidney failure. Analytical and numerical predictions of long-term HIV+ ESKD prevalence show that therapy can lead to either extremely low levels of disease prevalence or increased prevalence, depending on drug efficacy levels and mechanisms of action. Maintenance of HIV+ ESKD prevalence below one individual is possible with sufficient efficacy (e.g., 99%) against the progression from …
Data For "Arch_Covid_Crowding_Vc", Wayne Freimund, Zachary D. Miller
Data For "Arch_Covid_Crowding_Vc", Wayne Freimund, Zachary D. Miller
Browse all Datasets
Monitoring of visitor use in Arches National Park to assess social distancing behaviors of visitors during the COVID-19 pandemic.
Computing For Numeracy: How Safe Is Your Covid-19 Social Bubble?, Charles Connor
Computing For Numeracy: How Safe Is Your Covid-19 Social Bubble?, Charles Connor
Numeracy
The COVID-19 pandemic has led many people to form social bubbles. These social bubbles are small groups of people who interact with one another but restrict interactions with the outside world. The assumption in forming social bubbles is that risk of infection and severe outcomes, like hospitalization, are reduced. How effective are social bubbles? A Bayesian event tree is developed to calculate the probabilities of specific outcomes, like hospitalization, using example rates of infection in the greater community and example prior functions describing the effectiveness of isolation by members of the social bubble. The probabilities are solved for two contrasting …
Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff
Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff
Undergraduate Honors Theses
Annual Lyme disease cases continue to rise in the U.S. making it the most reported vector-borne illness in the country. The pathogen (Borrelia burgdorferi) and primary vector (Ixodes scapularis; blacklegged tick) dynamics of Lyme disease are complicated by the multitude of vertebrate hosts and varying environmental factors, making models an ideal tool for exploring disease dynamics in a time- and cost-effective way. In the current study, LYMESIM 2.0, a mechanistic model, was used to explore the effectiveness of three commonly used tick control methods: habitat-targeted acaricide (spraying), rodent-targeted acaricide (bait boxes), and white-tailed deer targeted acaricide (4-poster …
Spatio-Temporal Modelling Of Tick Life-Stage Count Data With Spatially Varying Coefficients, Thabo Lephoto, Henry Mwambi, Oliver Bodhlyera, Holly Gaff
Spatio-Temporal Modelling Of Tick Life-Stage Count Data With Spatially Varying Coefficients, Thabo Lephoto, Henry Mwambi, Oliver Bodhlyera, Holly Gaff
Biological Sciences Faculty Publications
There is a vast amount of geo-referenced data in many fields of study including ecological studies. Geo-referencing is usually by point referencing; that is, latitudes and longitudes or by areal referencing, which includes districts, counties, states, provinces and other administrative units. The availability of large geo-referenced datasets for modelling has necessitated the development and application of spatial statistical methods. However, spatial varying coefficients models exploring the abundance of tick counts remain limited. In this study we used data that was collected and prepared by researchers in the Department of Biological Sciences from the Old Dominion University, Virginia, USA. We modelled …
Development Of Environmental Metabarcoding Analysis For Use In Ecological Studies Of Aquatic Fungal And Oomycete Communities Using Nanopore Sequencing, Douglas Bennett
Development Of Environmental Metabarcoding Analysis For Use In Ecological Studies Of Aquatic Fungal And Oomycete Communities Using Nanopore Sequencing, Douglas Bennett
All Master's Theses
One of several factors contributing to amphibian decline are organisms called water molds (oomycetes), which parasitize and kill amphibian and fish eggs, larvae, and occasionally adults. Amphibian decline is one of the most difficult issues facing ecologists and conservationists to date; half of amphibian species are in severe decline and one third of amphibian species are facing extinction, threatening the stability of ecosystems globally. Multiple oomycete species are known to cause the disease saprolegniasis and contribute to amphibian decline; however, the full range of species involved is not presently known. This study evaluated the Oxford Nanopore minION DNA sequencer (R9.2 …
Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team
Kynurenic Acid May Underlie Sex-Specific Immune Responses To Covid-19, Yuping Cai, Daniel J. Kim, Takehiro Takahashi, David I. Broadhurst, Hong Yan, Shuangge Ma, Nicholas J. W. Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J. Moore, M. Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I. Ko, Sajid A. Khan, Akiko Iwasaki, Caroline H. Johnson, Yale Impact Research Team
Research outputs 2014 to 2021
Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences. Because immune responses are, in part, regulated by metabolites, we examined the serum metabolomes of COVID-19 patients. In male patients, kynurenic acid (KA) and a high KA–to–kynurenine (K) ratio (KA:K) positively correlated with age and with inflammatory cytokines and chemokines and negatively correlated with T cell responses. Males that clinically deteriorated had a higher KA:K than those that stabilized. KA inhibits glutamate release, and glutamate abundance was lower in patients that clinically deteriorated and correlated with immune responses. Analysis of …