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Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Ecology and Evolutionary Biology

2018

Washington University in St. Louis

Articles 1 - 2 of 2

Full-Text Articles in Physical Sciences and Mathematics

Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King Dec 2018

Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King

Arts & Sciences Electronic Theses and Dissertations

Understanding how genotype leads to phenotype is key to understand both the development and dysfunction of complex organisms. In the context of regulating the gene expression patterns that contribute to cell identity and function, the goal of my thesis research is to how changes in genome sequence may impact impact gene expression by determining how sequence features contribute to regulatory potential. To accomplish this goal, I first leveraged the key regulatory role of pluripotency transcription factors (TFs) in mouse embryonic stem cells (mESCs) and tested synthetically generated and genomic identified combinations of binding site for four TFs, OCT4, SOX2, KLF4, …

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Preventing Extinction Of At-Risk Plant Species In A Complex World, Holly Lee Bernardo Aug 2018

Preventing Extinction Of At-Risk Plant Species In A Complex World, Holly Lee Bernardo

Arts & Sciences Electronic Theses and Dissertations

Earthճ current biodiversity crisis is now considered a true mass extinction event, with species level extinction rates well above background rates and population level extinction rates orders of magnitude more common that species extinctions. There are many threats driving this loss of biodiversity. How each threat impacts the viability of a species is highly context dependent, but all are anthropogenic in origin and so as the human population continues to increase, so too will the pressure of these threats on our natural systems. Ultimately, how much a threat decreases the viability of a species depends on how that threat influences …

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