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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Scientists And Activists Work To Save The Planet, Myriam G. Vidal Valero
Scientists And Activists Work To Save The Planet, Myriam G. Vidal Valero
Capstones
Climate change and human intervention in nature are affecting people, ecosystems and ways of living all over the world. This portfolio of environmental pieces showcases the dire consequences of not addressing these issues, how solutions can be reached and the challenges facing those who try to change things.
Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed
Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed
Dissertations, Theses, and Capstone Projects
Computational prediction of a phenotypic response upon the chemical perturbation on a biological system plays an important role in drug discovery and many other applications. Chemical fingerprints derived from chemical structures are a widely used feature to build machine learning models. However, the fingerprints ignore the biological context, thus, they suffer from several problems such as the activity cliff and curse of dimensionality. Fundamentally, the chemical modulation of biological activities is a multi-scale process. It is the genome-wide chemical-target interactions that modulate chemical phenotypic responses. Thus, the genome-scale chemical-target interaction profile will more directly correlate with in vitro and in …