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Selective Iodination Using Diaryliodonium Salts, William H. Miller Iv
Selective Iodination Using Diaryliodonium Salts, William H. Miller Iv
Department of Chemistry: Dissertations, Theses, and Student Research
Aryl iodides have become widely recognized as versatile synthetic intermediates, owing to aromatic iodine’s excellent ability to participate in oxidative addition reactions. Iodoarenes readily undergo a variety of synthetic transformations including metal catalyzed cross-coupling reactions, diaryliodonium chemistry, formation of organometallics through reduction or metal-halogen exchange, as well as classical SN2 type chemistry. Because a wide array of transformations are available for aryl iodides, organic molecules containing this moiety often serve as vital precursors to highly desirable pharmaceuticals.
This thesis describes a simple and selective two-step approach to the formation of aryl iodides. This method proceeds through an easily …