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Stereochemical Investigation Of A Novel Tandem Intramolecular Diels-Alder Reaction, Katie Pelham
Stereochemical Investigation Of A Novel Tandem Intramolecular Diels-Alder Reaction, Katie Pelham
Chemistry Senior Theses
The Diels-Alder reaction has become a prominent synthetic tool due to the effectiveness for which it facilitates the construction of new carbon-carbon bonds to form six-membered rings. Since first reported in 1952, Intramolecular Diels-Alder (IMDA) reactions have been widely employed for complex synthesis, especially for natural products. Our lab was the first to report a Tandem Intramolecular Diels-Alder (TIMDA) reaction, and TIMDA reactions have similarly proved powerful in the synthesis of natural products. Predicting the absolute stereochemistry of the major products of such intramolecular reactions is complicated by the competition between steric factors imposed by the necessary distortion of the …