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On The Conformational Dynamics Of Dna: A Perspective From Molecular Dynamics Simulations, Ning Ma
On The Conformational Dynamics Of Dna: A Perspective From Molecular Dynamics Simulations, Ning Ma
USF Tampa Graduate Theses and Dissertations
The main focus of my dissertation is on the conformational motion of DNA, studied by applying tools from the computational chemistry field. In addition, studies of relative α- and 310 helical stabilities in peptides/mini-proteins, and a molecular flooding study of the retinoid X-receptor as part of a continuing drug design effort are presented. In molecular biology, it has been well known that sequence determines structure, and structure controls function. For proteins or DNA to work properly, the correct configuration is required. Mutations may alter the structure, which can cause malfunction. Non-mutational effects, such as a change in environment may also …