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Full-Text Articles in Translational Medical Research
Regulation Of Skeletal Muscle Plasticity By The Gut Microbiome, Taylor R. Valentino
Regulation Of Skeletal Muscle Plasticity By The Gut Microbiome, Taylor R. Valentino
Theses and Dissertations--Physiology
Recent evidence suggests that the gut microbiome could play a role in skeletal muscle plasticity, providing novel treatments for muscle wasting diseases and/or performance enhancements. I first sought to determine if the gut microbiome is necessary for skeletal muscle adaptation to exercise. Forty-two, four-month old, female C57Bl/6J underwent nine weeks of weighted wheel running or remained in cage with a locked wheel, without or without the administration of antibiotics (treated). In response to wheel running, I found that antibiotic depletion of the microbiome led to a blunted hypertrophic response in the soleus muscle as measured by normalized muscle wet weight …
The Mechanical Properties Of Non-Failing And Failing Human Myocardium, Cheavar A. Blair
The Mechanical Properties Of Non-Failing And Failing Human Myocardium, Cheavar A. Blair
Theses and Dissertations--Physiology
Heart failure is a clinical syndrome that manifests when there are structural and functional impairments to the heart that reduces the ability of the ventricles to fill or eject blood. The syndrome affects ~6 million Americans and is responsible for nearly 300,000 deaths annually. At the core of the syndrome are dysfunctional sarcomeres, the machinery that drives cardiac contraction and relaxation. By assessing the mechanical properties of human cardiac tissue, the information provided in this dissertation will provide data that demonstrates how sarcomeric dysfunction contributes to heart failure in the left and right ventricles. Additionally, these data will supply information …