Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Sports Sciences
The Effect Of The Cyp1a2 -163 C>A Polymorphism On The Metabolism Of Caffeine And Effect On Performance, Gabrielle E. Giersch
The Effect Of The Cyp1a2 -163 C>A Polymorphism On The Metabolism Of Caffeine And Effect On Performance, Gabrielle E. Giersch
Masters Theses, 2010-2019
Prior studies from our laboratory suggest that the -163 C > A polymorphism of the Cytochrome P450 (CYP1A2) gene influences the ergogenic effect of caffeine. Although this polymorphism has been known to influence the inducibility of hepatic CYP1A2 and the rate of caffeine metabolism, levels of caffeine and/or metabolites have never been reported in these aforementioned studies (1, 12, 16). Thus, a mechanistic link between the polymorphism and the ergogenic effect of caffeine is lacking. The purpose of this study was to determine if the CYP1A2 polymorphism affected caffeine metabolism between the genotypes (AA homozygotes and C allele carriers). Twenty male …