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Articles 1 - 6 of 6
Full-Text Articles in Clinical Epidemiology
What Are The Basic Self-Monitoring Components For Cardiovascular Risk Management?, Alison M. Ward, Carl Heneghan, Rafael Perera, Dan Lasserson, David Nunan, David Mant, Paul P. Glasziou
What Are The Basic Self-Monitoring Components For Cardiovascular Risk Management?, Alison M. Ward, Carl Heneghan, Rafael Perera, Dan Lasserson, David Nunan, David Mant, Paul P. Glasziou
Paul Glasziou
Background: Self-monitoring is increasingly recommended as a method of managing cardiovascular disease. However, the design, implementation and reproducibility of the self-monitoring interventions appear to vary considerably. We examined the interventions included in systematic reviews of self-monitoring for four clinical problems that increase cardiovascular disease risk.
Methods: We searched Medline and Cochrane databases for systematic reviews of self-monitoring for: heart failure, oral anticoagulation therapy, hypertension and type 2 diabetes. We extracted data using a pre-specified template for the identifiable components of the interventions for each disease. Data was also extracted on the theoretical basis of the education provided, the rationale given …
Corticosteroids For Pain Relief In Sore Throat: Systematic Review And Meta-Analysis, Gail Hayward, Matthew J. Thompson, Carl J. Heneghan, Rafael Perera, Paul P. Glasziou, Chris B. Del Mar
Corticosteroids For Pain Relief In Sore Throat: Systematic Review And Meta-Analysis, Gail Hayward, Matthew J. Thompson, Carl J. Heneghan, Rafael Perera, Paul P. Glasziou, Chris B. Del Mar
Paul Glasziou
Objective: To evaluate whether systemic corticosteroids improve symptoms of sore throat in adults and children. Design: Systematic review and meta-analysis. Data sources: Cochrane Central, Medline, Embase, Database of Reviews of Effectiveness (DARE), NHS Health Economics Database, and bibliographies. Outcome measures: Percentage of patients with complete resolution at 24 and 48 hours, mean time to onset of pain relief, mean time to complete resolution of symptoms, days missed from work or school, recurrence, and adverse events. Results: We included eight trials, consisting of 743 patients in total (369 children, 374 adults). 348 (47%) had exudative sore throat, and 330 (44%) were …
Event Rates, Hospital Utilization, And Costs Associated With Major Complications Of Diabetes: A Multicountry Comparative Analysis, Philip M. Clarke, Paul Glasziou, Anushka Patel, John Chalmers, Mark Woodward, Stephen B. Harrap, Joshua A. Salomon
Event Rates, Hospital Utilization, And Costs Associated With Major Complications Of Diabetes: A Multicountry Comparative Analysis, Philip M. Clarke, Paul Glasziou, Anushka Patel, John Chalmers, Mark Woodward, Stephen B. Harrap, Joshua A. Salomon
Paul Glasziou
Background: Diabetes imposes a substantial burden globally in terms of premature mortality, morbidity, and health care costs. Estimates of economic outcomes associated with diabetes are essential inputs to policy analyses aimed at prevention and treatment of diabetes. Our objective was to estimate and compare event rates, hospital utilization, and costs associated with major diabetes-related complications in high-, middle-, and low-income countries.
Methods and Findings: Incidence and history of diabetes-related complications, hospital admissions, and length of stay were recorded in 11,140 patients with type 2 diabetes participating in the Action in Diabetes and Vascular Disease (ADVANCE) study (mean age at entry …
Self Diagnosis, Clare Goyder, Ann Mcpherson, Paul Glasziou
Self Diagnosis, Clare Goyder, Ann Mcpherson, Paul Glasziou
Paul Glasziou
Extract:
Some conditions can be diagnosed correctly by the patient, but self diagnosis should always undergo challenge and refinement by the general practitioner.
A Novel Method To Adjust Efficacy Estimates For Uptake Of Other Active Treatments In Long-Term Clinical Trials, John Simes, Merryn Voysey, Rachel O'Connell, Paul Glasziou, James D. Best, Russell Scott, Christopher Pardy, Karen Byth, David R. Sullivan, Christian Ehnholm, Anthony Keech
A Novel Method To Adjust Efficacy Estimates For Uptake Of Other Active Treatments In Long-Term Clinical Trials, John Simes, Merryn Voysey, Rachel O'Connell, Paul Glasziou, James D. Best, Russell Scott, Christopher Pardy, Karen Byth, David R. Sullivan, Christian Ehnholm, Anthony Keech
Paul Glasziou
Background: When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons. In the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, patients were randomized to fenofibrate or placebo, but during the trial many started additional drugs, particularly statins, more so in the placebo group. The effects of fenofibrate estimated by intention-to-treat were likely to have been attenuated. We aimed to quantify this effect and to develop a …
Tonsillectomy Or Adeno-Tonsillectomy Versus Non-Surgical Treatment For Chronic/Recurrent Acute Tonsillitis (Review), Martin Burton, Paul Glasziou
Tonsillectomy Or Adeno-Tonsillectomy Versus Non-Surgical Treatment For Chronic/Recurrent Acute Tonsillitis (Review), Martin Burton, Paul Glasziou
Paul Glasziou
Background: Surgical removal of the tonsils, with or without adenoidectomy (adeno-/tonsillectomy), is a common ENT operation but the indications for surgery are controversial.
Objectives: To determine the effects of tonsillectomy, with and without adenoidectomy, in patients with chronic/recurrent acute tonsillitis. Search methods: The Cochrane Ear, Nose and Throat Disorders Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, issue 2), MEDLINE (1966 to 2008), EMBASE (1974 to 2008), bibliographies, and additional sources were searched for published and unpublished trials. The date of the last search was 11 April 2008.
Selection criteria: Randomised controlled …